Traditional Chinese medicine preparation for warming meridians to disperse blood stasis and preparation method thereof
A traditional Chinese medicine preparation and warming meridian technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of unsatisfactory effect, long treatment period, slow effect, etc., and achieve good social value and economic benefits. , the preparation method is simple, the effect of high cure rate
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Embodiment 1
[0033] (1) A Chinese medicine for warming the meridians and removing blood stasis, which is formed by the proportioning of the following raw materials by weight:
[0034] 30 parts of Poria cocos, 25 parts of woody fragrance, 20 parts of Yuanhu, 15 parts of lotus seed heart, 15 parts of Hedyotis diffusa, 10 parts of snow lily, 10 parts of Acanthopanax, 10 parts of Fructus chinensis, 10 parts of Dijincao, 5 parts of rushes and 5 parts of astragalus.
[0035] (2) Preparation method:
[0036] In the first step, Poria cocos, woody fragrance and Yuanhu are mixed in proportion, and the ethanol with an alcohol concentration of 70-80% equivalent to 2-3 times the mass of the mixture is refluxed for 2-4 times, and the filtrates are combined, concentrated under reduced pressure, dried and Grinding into powder, followed by purification with n-propanol for 1-2 times, combining the extracts, recovering n-propanol under reduced pressure and concentrating to a paste with a relative density of...
Embodiment 2
[0041] (1) A kind of Chinese medicine for warming the meridians and removing blood stasis, which is formed by the proportioning of the following raw materials by weight: the same as in Example 1.
[0042] (2) Preparation method:
[0043] In the first step, Poria cocos, woody fragrance and Yuanhu are mixed in proportion, and the ethanol with an alcohol concentration of 70-80% equivalent to 2-3 times the mass of the mixture is refluxed for 2-4 times, and the filtrates are combined, concentrated under reduced pressure, dried and Grinding into powder, followed by purification with n-propanol for 1-2 times, combining the extracts, recovering n-propanol under reduced pressure and concentrating to a paste with a relative density of 1.21-1.24 at 60°C, drying and pulverizing into powder;
[0044] The second step is to extract the lotus seed heart, Hedyotis diffusa, Xuelikai, and Acanthopanax 2-3 times with ethanol with an alcohol concentration of 80-90%, combine the extracts, concentra...
Embodiment 3
[0048] 1. Long-term toxicity test process:
[0049] Apply Wistar rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. provides) experimental medicine is set to high, medium and low three dosages, be respectively the capsule 8g / kg, 4g / kg, 2g of embodiment 1 formula / kg. Calculated according to the human dose of 0.1g / kg / day tablet, it is 80 times, 40 times and 20 times of the effective dose for human respectively; another control group is set up, which is given continuously for 90 days and 180 days by intragastric administration and part of the animals are withdrawn for 10 days. Days later, the effects on various physiological and biochemical indicators of rats were observed. The experimental results show that: continuous oral administration of different doses to rats for 180 days has no effect on the food intake and weight growth of the rats. No significant toxic effects were found on liver and kidney function. There was no obvious effect on blood routine, bl...
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