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A nano-alloy anticancer drug with autonomous targeting and imaging functions and its preparation method

A nano-alloy and anti-cancer drug technology, which is applied to medical preparations containing active ingredients, drug combinations, anti-tumor drugs, etc., can solve the problems of time-consuming, money-consuming, difficult to distinguish, etc.

Active Publication Date: 2018-10-09
郑州天兆医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the search for special antibody-antigen pairs that are different from normal cells is very time-consuming and expensive. At the same time, the difference between some antibody-antigen pairs of cancer cells and normal cells is very small and difficult to distinguish. Therefore, it is easy Kill a large number of normal cells, with great toxic side effects

Method used

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  • A nano-alloy anticancer drug with autonomous targeting and imaging functions and its preparation method
  • A nano-alloy anticancer drug with autonomous targeting and imaging functions and its preparation method
  • A nano-alloy anticancer drug with autonomous targeting and imaging functions and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] In the following, Au@CoFeB@(CoFe)-O(OH) x @(LHRH-HECATE) (LHRH: gonadotropin-secreting hormone; HECATE: cell membrane lysin peptide) is used as an example to illustrate its preparation process and its application effect in the treatment of cancer cells.

[0065] (1) Put a certain amount of metal salt FeCl in a three-necked flask 2 4H 2 O (0.07g (0.35mmol), CoCl 2 ·6H 2 O (0.0833g, 0.35mmol) and a certain amount of stabilizer PVP (0.42g, Mw=10000) were dissolved in N-methylpyrrolidone (50mL, NMP), and nitrogen protection was kept in the bottle. (2) A certain amount of reducing agent NaBH 4 (0.4g, 10.25mmol) was dissolved in 50mL of NMP in a three-necked flask protected by nitrogen. (3) React in a tubular microfluidic reactor, set the reaction rate to 3.0ml / min, and the reaction temperature to 100°C (constant temperature tank a and b), and collect the product at 4°C (constant temperature tank c), to prepare a structurally stable and Monodisperse CoFeB nanoparticles ...

Embodiment 2

[0078] This example illustrates the preparation of FePtB@Fe with different morphologies (core-shell or alloy crystal structure) by the mixed-salt method using one of the programmed microfluidic primitives in the multi-step programmed microfluidic preparation method by adjusting the ratio of reactants. 3 o 4 Nanoparticles, and compared the anticancer effects of iron or Pt particles containing only a single component.

[0079] Preparation of FePtB@Fe by a single-program microfluidic primitive process 3 o 4 Example methods of nanoparticles are as follows.

[0080] (1) 0.07g (0.35mmol) of FeCl 2 4H 2 O, 0.3g of PVP (Mw=10000) and 0.017g (0.032mmol) of H 2 PtCl 6 ·6H 2 O is dissolved in 50mL of NMP solvent to form a mixed metal salt solution, and the mixed metal salt solution is pumped into the micro-preheating channel (3) controlled by the constant temperature tank a to preheat to 120°C through the pump (1). The inner diameter of the hot channel is 127μm and the length is ...

Embodiment 3

[0086] H in Example 2 2 PtCl 6 ·6H 2 The amount of O was increased to 0.061g (0.117mmol); and the temperature of the constant temperature bath b used in the growth stage was increased to 85°C, and the rest of the reaction conditions remained unchanged. The transmission electron micrographs of the prepared nanoparticles are as follows: Figure 9 a, Statistical results show that the particle size is 2.1±0.4nm. Although there is segregation when the shell layer is formed, the core-shell morphology can be clearly seen from the contrast of the inner layer and the surface layer of the high-resolution transmission electron microscope photos of individual particles, and the darker core is the FePtB alloy core layer (middle circled by the dotted line), the lattice constant of 0.211nm is the (111) plane of face-centered cubic FePtB, and the lighter part is the shell layer composed of Fe and Fe oxides (the circle circled by the two dotted lines part). It can also be seen that the cr...

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Abstract

The invention relates to a nanometer alloy anti-cancer drug with functions of independent targeting and imaging, and a preparation method thereof, and belongs to the technical field of anti-cancer drugs. The nanometer alloy anti-cancer drug mainly comprises a metal, a metal compound and a nonmetal, wherein the metal comprises at least one selected from precious metal components such as Au, Ag, Pt, Cu, Ru, Pd, Rh, Re, Os and Ir and is named a first component, the nonmetal is at least one selected from nonmetal element components such as B, C, Si, O, S and Se and is named a second component, O exists in the form of the metal oxide or the hydroxyl OH or carboxyl COOH on the particle surface, S and Se exist mainly in the form of the sulfide or selenide formed from S or Se and the metal, B and Si are doped in the metal to form the alloy, and C exists in the form of the carbon allotrope, or the surface-coated organic carbon, or the metal carbide formed from C and the metal.

Description

technical field [0001] The invention belongs to the field of preparation of nanomedicine and its application in biomedical engineering, and in particular relates to a method for preparing metal alloy-metal compound heterogeneous nanostructure particles with an amorphous to crystalline phase structure and a pair of these particles in the middle and late stages. The treatment of liver cancer, lung cancer, lymphoma, breast cancer and blood cancer belongs to the technical field of anticancer drugs. Background technique [0002] Due to the aggravation of environmental pollution and changes in dietary structure, in the past few decades, the probability of human beings suffering from various cancers has become higher and higher. For example, due to air pollution, the smog in China in the past five years, represented by the Beijing-Tianjin-Hebei region and the Yangtze River Delta region, has increased the prevalence of lung cancer in these regions with an annual growth rate of more ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61K49/00A61K49/04A61K41/00A61K33/38A61K33/24A61K33/34A61P35/00B22F9/24
Inventor 宋文琪宋玉军
Owner 郑州天兆医疗科技有限公司
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