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Colestilan dispersible tablet and preparation method thereof

A technology of colestiline and dispersible tablets, applied in the field of pharmaceutical preparations, can solve the problems of not being able to exert the maximum efficacy, slow drug dissolution and the like

Inactive Publication Date: 2016-04-13
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the commonly used dosage forms are tablets and granules prepared by film coating method, the drug dissolution rate is slow, and the drug effect cannot be maximized

Method used

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  • Colestilan dispersible tablet and preparation method thereof
  • Colestilan dispersible tablet and preparation method thereof
  • Colestilan dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021]

[0022] Preparation Process:

[0023] Pass A through a 100-mesh sieve, B-G pass through a 80-mesh sieve respectively, and mix A-G through a 60-mesh sieve to obtain a mixture, add 30% ethanol to the mixture to make a soft material, granulate with a 20-mesh sieve, and control the drying temperature at 50°C. The water content of the granules is controlled to be below 30%, and the granules are sized. After the obtained granules are mixed with the prescription quantities G and H, they are compressed into 1000 tablets on a tablet machine and packed after passing the inspection.

Embodiment 2

[0025] Preparation of Colestiline Dispersible Tablets

[0026] Prescription (in doses of 1000 tablets)

[0027]

[0028] Preparation Process:

[0029] Differentiate A to 20 μm, pass B-G through 80-mesh sieve respectively, and mix A-G through 60-mesh sieve to obtain a mixture, add 30% ethanol to granulate the mixture, control the drying temperature at 50°C, and control the moisture content of the granules below 30% After the obtained granules are mixed with the prescription quantities G and H, they are compressed into 1000 tablets on a tablet machine, and are packaged after passing the inspection.

Embodiment 3

[0031] Preparation of Colestiline Dispersible Tablets

[0032] Prescription (in doses of 1000 tablets)

[0033]

[0034] Preparation Process:

[0035] Differentiate A to 10 μm, pass B-G through 80-mesh sieve respectively, and mix A-G through 60-mesh sieve to obtain a mixture, add 30% ethanol to granulate the mixture, control the drying temperature at 50°C, and control the moisture content of the granules below 30% After the obtained granules are mixed with the prescription quantities G and H, they are compressed into 1000 tablets on a tablet machine, and are packaged after passing the inspection.

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Abstract

The invention discloses a colestilan dispersible tablet and a preparation method of the colestilan dispersible tablet. The colestilan dispersible tablet is prepared by firstly carrying out micronizing treatment on medicine colestilan so that the grain size of the medicine colestilan is controlled to be 20 mu m or below, and then adding with auxiliary materials. Compared with a common tablet, the colestilan dispersible tablet contains no surfactant, the solubleness, the dispersibility and the disintegration of the colestilan dispersible tablet are good, and the colestilan dispersible tablet can complete the disintegration operation within one minute. The colestilan dispersible tablet prepared by adopting the preparation method has the advantages that the preparation method is simple and feasible, and is suitable for industrial production. The colestilan dispersible tablet has obvious effects in treating hypercholesteremia and familial hypercholesterolemia, and has a good market promotion prospect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a colestylan dispersible tablet. Background technique [0002] Colestilan was developed by Japan's Mitsubishi Pharmaceutical Company and was first approved for marketing in Japan in July 1999 for the treatment of hypercholesterolemia and familial hypercholesterolemia. [0003] Corestiline is a type of anion exchange resin that affects the absorption of bile acids and cholesterol. Its mechanism of action is to absorb bile acids in the digestive tract, inhibit the reabsorption of bile acids and cholesterol, thereby promoting the excretion of bile acids and cholesterol, and increase intrahepatic UDL receptors to promote blood LDL into the liver, thereby reducing blood LDL. Compared with the similar drug cholestyramine, it shows that it has a larger adsorption capacity and affinity with most bile acids, which can effectively reduce the total bile acid content in the portal...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/787A61K47/26A61K47/38A61K47/36A61K47/32A61K47/02A61P3/06
CPCA61K9/0095A61K9/2009A61K9/2018A61K9/2027A61K9/2054A61K9/2059A61K31/787
Inventor 刘冲张庭
Owner BEIJING VENTUREPHARM BIOTECH