Stable photo-responsive Pickering emulsion with photosensitive POSS hybrid particles as emulsifying agent and preparation method

A technology of hybrid particles and photoresponsiveness, which is applied in the direction of medical preparations, cosmetic preparations, and cosmetics with non-active ingredients, can solve the problem of few light-sensitive emulsions, and achieve good promotion and application value and operability Strong, easy-to-use effect

CN105496799AInactive Publication Date: 2016-04-20NORTHWESTERN POLYTECHNICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2016-04-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a stable photo-responsive Pickering emulsion with photosensitive POSS hybrid particles as an emulsifying agent and a preparation method. Octa(gamma-chloropropyl) POSS serves as an initiator, an azobenzene-containing double-bond compound serves as a monomer, and the photosensitive POSS hybrid particles are prepared through the atom transfer radical polymerization (ATRP) method. The water-in-oil (W / O) type Pickering emulsion is obtained through shear field emulsification. The method is simple, feasible, high in operability and capable of being applied to the field of cosmetics. Through external stimuli, the emulsion is demulsified and release moisture of an internal phase so that skin can be moistened or prevented from being harmed by ultraviolet rays. The emulsion can also be applied to the field of drug sustained release, and through UV irradiation, controllable release of internal phase medicine is achieved. Accordingly, the emulsion can be widely used in the fields such as cosmetics, biology and pesticide delivery, and has very good application and popularization value.
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Description

technical field

[0001] The invention belongs to the field of sustained release of cosmetics and medicines, and in particular relates to a photoresponsive Pickering emulsion with photosensitive POSS hybrid particles as an emulsifier and a preparation method thereof. Background technique

[0002] Pickering emulsion is a stable emulsion of solid particles. Compared with traditional emulsions, Pickering emulsion has the advantages of low toxicity, environmental friendliness, easy separation, easy recycling, and reusability. In recent years, it has shown important applications in the fields of food, cosmetics, and medicine. The value has been widely concerned by scholars at home and abroad. Due to the differences in the application fields of emulsions with different properties, the requirements for their stability are also different. For example, food and asphalt require high stability, while crude oil recovery systems require low stability. Therefore, the construction of respon...

Examples

example 1

[0026] (1) Preparation of photosensitive POSS hybrid particles

[0027] Dissolve octachloropropyl POSS in N,N-dimethylformamide, stir until completely dissolved, the mass ratio of octachloropropyl POSS to N,N-dimethylformamide is 1:80, add azobenzene monomer, the amount of azobenzene monomer added is 1.2 times that of octachloropropyl POSS, then add catalyst cuprous bromide / tris(2-methylaminoethyl)amine, and the system reacts under the protection of hydrogen or nitrogen, The reaction temperature is 70°C, the reaction time is 16 hours, the product is dissolved in chloroform, after the catalyst is removed, the chloroform is removed by rotary evaporation, and then precipitated by n-hexane, and the precipitate is filtered and dried to constant weight to obtain azobenzene-containing group of POSS hybrid particles.

[0028] (2) Preparation of a stable W / O Pickering emulsion with photoresponsiveness

[0029] Take a certain amount of hydrophobic photosensitive POSS hybrid particles,...

example 2

[0031] (1) Preparation of photosensitive POSS hybrid particles

[0032] Dissolve octachloropropyl POSS in toluene, stir until completely dissolved, the mass ratio of octachloropropyl POSS to toluene is 1:120, add azobenzene monomer, the amount of azobenzene monomer added is octachloropropane 1.5 times that of the base POSS, then add the catalyst cuprous chloride / pentamethyldiethylenetriamine, the system reacts under the protection of hydrogen or nitrogen, the reaction temperature is 80 ° C, the reaction time is 18 hours, the product is dissolved in tetrahydrofuran, After the catalyst is removed, tetrahydrofuran is removed by rotary evaporation, and then precipitated by anhydrous methanol, and the precipitate is filtered and dried to a constant weight to obtain POSS hybrid particles containing azophenyl groups.

[0033] (2) Preparation of a stable W / O Pickering emulsion with photoresponsiveness

[0034] Take a certain amount of hydrophobic photosensitive POSS hybrid particles,...

example 3

[0036] (1) Preparation of photosensitive POSS hybrid particles

[0037] Dissolve octachloropropyl POSS in N,N-dimethylformamide, stir until completely dissolved, the mass ratio of octachloropropyl POSS to toluene is 1:100, add azobenzene monomer, the added azobenzene The amount of monomer is twice that of octachloropropyl POSS, then add catalyst cuprous chloride / pentamethyldiethylenetriamine, the system reacts under the protection of hydrogen or nitrogen, the reaction temperature is 90°C, and the reaction time is 20 hours , the product was dissolved in dichloromethane, after the catalyst was removed, the dichloromethane was removed by rotary evaporation, and then precipitated by cyclohexane, and the precipitate was filtered and dried to constant weight to obtain the POSS hybrid particles.

[0038] (2) Preparation of a stable W / O Pickering emulsion with photoresponsiveness

[0039]Take a certain amount of hydrophobic photosensitive POSS hybrid particles, add them to toluene, ...