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Application of micheliolide dimethylamine

A technology of dimethylamine and lactone, which is applied in the application field of microlactone dimethylamine, to achieve the effect of increasing the blood supply to the lungs, being easy to accept, and easy to obtain

Active Publication Date: 2016-04-27
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE +1
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

The clinical effectiveness of other drugs is also controversial to varying degrees

Method used

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  • Application of micheliolide dimethylamine
  • Application of micheliolide dimethylamine
  • Application of micheliolide dimethylamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Establishment of mouse pulmonary fibrosis model and pharmacodynamic detection of ACT001

[0036] Experimental method and steps:

[0037] 1. Establishment of mouse pulmonary fibrosis model and drug treatment

[0038] 1.1 Establishment of mouse pulmonary fibrosis model

[0039] The 36 mice were randomly divided into three groups, normal group, control group (pulmonary fibrosis model group), and ACT001 group (administered with ACT001 after modeling), 12 in each group. Each mouse in the normal group was given 0.15 mL of 0.9% normal saline at one time; each mouse in the control group and ACT001 group was given 0.15 mL of an aqueous solution of methyl viologen hydrate at one time.

[0040]1.2 Administration and treatment of mice with pulmonary fibrosis

[0041] In the third week after modeling, the mice were given drug treatment. The normal group and the control group were intragastrically administered with 0.9% normal saline of 0.1 mL each time, and the ACT001 g...

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Abstract

The invention provides application of micheliolide dimethylamine (ACT001) to preparation of medicines for treating pulmonary fibrosis. The micheliolide dimethylamine (ACT001) is capable of decreasing pulmonary coefficients of pulmonary fibrosis mice to be approximate to normal level, reversing and inhibiting pulmonary fibrosis level of organisms, inhibiting pulmonary extracellular matrix overdeposition, improving lung blood supply, increasing lung blood supply quantity and relieving dyspnea, thereby being remarkably effective in treatment of pulmonary fibrosis.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to the application of mimilactone dimethylamine. Background technique [0002] Microlactone dimethylamine is a derivative of microlactone, which is prepared from the natural extract parthenolide, and is referred to as ACT001 in this article. Parthenolide is a sesquiterpene lactone compound purified from the herb tansy, which has anti-inflammatory, anti-tumor, anti-platelet aggregation and other characteristics. The current research on ACT001 is mainly focused on the treatment of skin infections, migraine, rheumatism, and treatment of tumors and other diseases. Studies have shown that ACT001 and parthenolide have the characteristics of anti-inflammation, anti-tumor, anti-platelet aggregation, inhibition of proliferation of vascular smooth muscle cells, and inhibition of osteoclast activity. They inhibit tumor necrosis factor (TNF-α), interleukin- 1 (interleukin-1, IL-1), IL-12 an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P11/00
Inventor 孙涛陈悦杨诚周红刚刘慧娟刘艳荣王静张成玉张强张向明秦源荆学双
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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