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Laser-pumped up-conversion fluorescence thermometry system

A technology of laser pumping and fluorescence temperature, which is applied in the direction of thermometers, measuring heat, measuring devices, etc., can solve the problems of lack of fluorescence temperature detection system, achieve the effect of studying temperature rise characteristics and avoiding inaccuracy

Active Publication Date: 2019-11-12
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, fluorescence temperature detection is still in the development stage, and there is still a lack of fluorescence temperature detection system based on up-conversion luminescence. If the laser-pumped up-conversion luminescence acquisition technology can be combined with temperature detection technology, a new type of fluorescence temperature detection system can be developed. It will be very helpful to improve the operability and real-time performance of fluorescence temperature detection, and provide a powerful tool for material science, life science and medical research, as well as the application of fluorescence temperature detection technology

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  • Laser-pumped up-conversion fluorescence thermometry system
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  • Laser-pumped up-conversion fluorescence thermometry system

Examples

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Embodiment 1

[0021] Example 1: Determination of the up-conversion fluorescent temperature probe NaLu using a laser-pumped up-conversion fluorescence thermometry system 0.78 Yb 0.2 Er 0.02 f 4 @NaLuF 4 Fluorescence-Temperature Calibration Curve

[0022] Nanomaterial NaLu for Upconversion Fluorescence Temperature Probe 0.78 Yb 0.2 Er 0.02 f 4 @NaLuF 4 Disperse in water, prepare 2 mL of 0.5 mg / mL solution, place the solution in a cuvette, and place it in such as figure 1 The sample stage 3 is shown. Use the cycle temperature controller 4 and the body phase thermometer 5 to change the temperature from 0°C to 90°C, and at the same time use 980 nm to excite the up-conversion fluorescence. The up-conversion luminescent signal passes through the filter 6 and intercepts the signal of a certain wavelength before being detected by the CCD. Received by the detector 7, the fluorescent signal received by the CCD detector 7 is integrated and compared with the fluorescent emission peak by the co...

Embodiment 2

[0023] Example 2: Microscopic temperature monitoring of an upconversion fluorescent temperature probe combined with a photothermal therapy material under photothermal excitation using a laser-pumped upconversion fluorescence thermometry system

[0024] Up-conversion fluorescent temperature probe NaLu combined with photothermal conversion material 0.78 Yb 0.2 Er 0.02 f 4 @NaLuF 4 Disperse in water and prepare 2 mL of 0.5 mg / mL solution. Use 300mW / cm 2 The solution is continuously irradiated with a 730 nm laser, and at different time points within 0-8 minutes, the temperature of the solution is measured using a bulk thermometer 5, excited with a 980 nm laser, and the up-conversion emission spectrum is collected, and the up-conversion luminescence signal passes through After the optical filter 6 intercepts the signal of a certain wavelength, it is received by the CCD detector 7, and the fluorescent signal received by the CCD detector 7 passes through the computer 8, and two ...

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Abstract

The invention belongs to the technical field of optical equipment, and specifically relates to a laser pumped up-conversion fluorescence temperature measurement system. The laser pumped up-conversion fluorescence temperature measurement system is composed of a semiconductor laser, a sample bench, a cycling thermostat, a buck-phase thermometer, an optical filter, a CCD detector and a computer. The system can perform real-time non-intruding type imaging on materials marked with temperature-sensitive up-conversion luminescent probes, cells or biological tissue and can monitor conditions of temperature change in the materials, the cells or the biological tissue through acquisition of up-conversion fluorescence. Besides, the system can detect correlation between optical properties and temperature response of the fluorescence temperature probes, can realize micro-area heating of the up-conversion fluorescence temperature probes and is used for determining the temperature of the photo-thermal conversion materials combined with the up-conversion fluorescence temperature probes. The system provided by the invention can improve the operability and the real-time performance of fluorescence temperature detection and provides a powerful tool for research of material science, life science and medical science and application of a fluorescence temperature detection technology.

Description

technical field [0001] The invention belongs to the technical field of optical equipment, and in particular relates to a laser-pumped up-conversion fluorescence temperature measurement system. Background technique [0002] Optical temperature sensing is of great significance in the fields of industry, military affairs, and medical treatment. Different from other contact temperature measurement methods such as thermal expansion temperature measurement, thermal resistance temperature measurement, thermoelectric temperature measurement, etc., optical temperature measurement can realize non-contact temperature detection of samples. For some ultra-small-scale samples such as cells, micro-nano Optical temperature measurement is an irreplaceable temperature measurement method for devices and samples that require low or no damage, such as living tissue. In view of the rapid development of fluorescence detection technology in recent decades, the sensitivity and accuracy of fluoresce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01K11/00
CPCG01K11/00
Inventor 李富友朱幸俊李家畅
Owner FUDAN UNIV
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