Magnetic resonance chemical exchange saturation transfer imaging method and system
A technology of magnetic resonance imaging and chemical exchange, which is applied in the direction of using nuclear magnetic resonance image system for measurement, magnetic resonance measurement, and magnetic variable measurement, can solve the problems of low imaging efficiency and limited signal sensitivity, and achieve improved signal-to-noise ratio, Effects of improving image quality and reducing scan repetitions
Active Publication Date: 2019-04-12
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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[0007] Based on this, it is necessary to provide a magnetic resonance chemical exchange saturation transfer imaging method and system for the problems of limited signal sensitivity and low imaging efficiency in the existing magnetic resonance chemical exchange saturation transfer imaging technology
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[0033] Based on magnetic resonance chemical exchange saturation transfer imaging technology, the present invention proposes a CEST imaging technology combined with segmented (Segmented) echo planar imaging (Echo planar imaging, EPI) acquisition method on the basis of traditional technology. The present invention utilizes the segmented EPI sequence data acquisition method to effectively increase the strength of the CEST signal, thereby reducing the number of scanning repetitions, thereby improving scanning efficiency; meanwhile, it can effectively improve the signal-to-noise ratio of the CEST signal, which is beneficial to the improvement of the sensitivity of the CEST signal, and at the same time Can effectively reduce distortion and improve image quality. Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.
[0034] Such as figure 2 and image 3 As shown, the present invention provides a magnetic res...
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The invention provides a magnetic resonance chemical exchange saturation transfer imaging method and a magnetic resonance chemical exchange saturation transfer imaging system. The magnetic resonance chemical exchange saturation transfer imaging method comprises a main RF pulse generating step, applying a short-time main RF saturation pulse which lasts for a first preset time for aiming at a specific RF point, thereby generating the contrast of a magnetic resonance imaging signal; an image acquisition step, segmentally acquiring image data in a reading-out direction or / and a phase encoding direction based on the applied main RF saturation pulse by means of a segmental planar echo acquisition method; and a sub-RF pulse generating step, after one-time image data acquisition by means of the segmental planar echo acquisition method, applying a sub-RF saturation pulse which lasts for a second preset time, thereby keeping the contrast of the magnetic resonance imaging signal. The magnetic resonance chemical exchange saturation transfer imaging method and the magnetic resonance chemical exchange saturation transfer imaging system settle problems of low signal sensitivity and low imaging efficiency in existing magnetic resonance chemical exchange saturation transfer imaging technology.
Description
technical field [0001] The invention relates to magnetic resonance CEST imaging technology, in particular to a magnetic resonance chemical exchange saturation transfer imaging method and system. Background technique [0002] Magnetic resonance CEST imaging method (Chemical exchange saturation transfer, CEST) research began in 2000, because of its new magnetic resonance contrast mechanism, it has quickly attracted widespread attention, and has become a new sensitive way to study chemical exchange and chemical dynamics of macromolecules. The principle is to selectively apply a radio frequency (radio frequency, RF) pulse signal of a special resonance frequency to saturate the corresponding protons (such as figure 1 (a), pool B), these protons will interact with surrounding water molecules (such as figure 1 (a), pool A) undergoes chemical exchange, and then part of the saturation is transferred to water molecules, and the strength of the CEST effect is reflected by detecting th...
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IPC IPC(8): G01R33/48
Inventor 刘新吴垠郑海荣江克钟耀祖
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI