Peritoneal dialysis fluid (lactate) medical composition

A technology of peritoneal dialysis solution and composition, which is applied in the direction of drug combination, drug delivery, blood diseases, etc.

Inactive Publication Date: 2016-06-08
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The weakly alkaline peritoneal dialysate with a pH value of 7.3-7.7 can also improve the problem of blood pH drop caused by long-term use of acidic peritoneal dialysate, which is beneficial to alleviate the accumulation of acidity in the body

Method used

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  • Peritoneal dialysis fluid (lactate) medical composition
  • Peritoneal dialysis fluid (lactate) medical composition
  • Peritoneal dialysis fluid (lactate) medical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The formula is as follows, the packaging specification is 1000ml / bag, and the data in the table is the formula equivalent to each bag of dialysate

[0029]

[0030] 1. Concentrated liquid preparation: Take 10% of the prescription amount of water for injection, add other ingredients of the prescription amount and stir until completely dissolved, then add medicinal charcoal 0.1-1%, stir evenly, leave it for 10-20 minutes, and pass through the 0.22μm terminal After filtration, it was steam sterilized at 115°C for 15 minutes to obtain a standby concentrate.

[0031] 2. Mix the dope and lye at a constant speed through Tris, water for injection, adjust the solution to 1000ml, and the pH value is the value in the above table, and then filter through the 0.22μm terminal and seal (1000ml per bag or 2000ml). Wherein the content of tris hydroxymethyl amino methane is less than 5%.

[0032] Use nitrogen protection during preparation and potting.

[0033] 3. Sterilization: 115...

Embodiment 2

[0036] The formula is as follows, the packaging specification is 1000ml / bag, and the data in the table is the formula equivalent to each bag of dialysate

[0037]

[0038]

[0039] The preparation method is the same as in Example 1.

Embodiment 3

[0041] The formula is as follows, the packaging specification is 1000ml / bag, and the data in the table is the formula equivalent to each bag of dialysate

[0042]

[0043] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention relates to a peritoneal dialysis fluid (lactate) which comprises 1.5-4.25% of glucose, 0.4-0.7% of sodium chloride, 0.02-0.03% of calcium chloride, 0.01-0.02% of magnesium chloride and 0.4-0.6% of sodium lactate. The peritoneal dialysis fluid is characterized in that the pH of the peritoneal dialysis fluid is adjusted to be 7.3-7.7 through trihydroxymethyl aminomethane.

Description

technical field [0001] The invention relates to a weak alkaline peritoneal dialysis fluid (lactate) pharmaceutical composition. Background technique [0002] Peritonealdialysis (PD) is an important renal replacement therapy (CRRT) for patients with end-stage renal failure. Compared with hemodialysis, it has the advantages of wide application range, high dialysis efficiency, good preservation of residual renal function, and high quality of life for patients. It occupies an increasingly important position in the replacement therapy of chronic renal failure. The key to successful peritoneal dialysis is a well-functioning ultrafiltration peritoneum and peritoneal dialysate. Due to the long-term nature of peritoneal dialysis treatment, the ultrafiltration performance of the peritoneum is often affected by various factors and changes during the treatment process, and this change is irreversible, which will eventually cause the loss of the peritoneal ultrafiltration function of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/08A61P7/08A61P11/00A61K33/06A61K31/7004
Inventor 孙亮
Owner TIANJIN JINYAO GRP
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