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Pump-driving-free micro-fluidic chip manufacturing method based on three-dimensional printing and product

A microfluidic chip and three-dimensional printing technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve problems such as high production costs, achieve simple and fast processing, and facilitate industrialized large-scale production , the effect of convenient detection

Active Publication Date: 2016-06-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Traditional microfluidic chips usually use materials such as glass, plexiglass, and silicone, which are relatively expensive to manufacture and require sophisticated pumps to drive reagents to flow in the channel for reaction.

Method used

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  • Pump-driving-free micro-fluidic chip manufacturing method based on three-dimensional printing and product
  • Pump-driving-free micro-fluidic chip manufacturing method based on three-dimensional printing and product
  • Pump-driving-free micro-fluidic chip manufacturing method based on three-dimensional printing and product

Examples

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Comparison scheme
Effect test

Embodiment

[0054] Embodiment: Taking the manufacture of a quincunx-shaped microfluidic chip and the detection of nitrite as examples, the manufacturing process mentioned in the present invention is further described.

[0055] figure 1 The three-dimensional model of the designed quincunx-shaped microfluidic chip substrate 1 is shown, and the three-dimensional model file is generated as an STL format file, and the obtained STL format file is imported into the three-dimensional printing software, and the printing parameter filling rate is set to 60. Connect to the computer, start the FDM three-dimensional printer, control the FDM three-dimensional printer to work through the computer, and start the printing process of the microfluidic chip substrate 1. Existing printing materials can be selected, such as polylactic acid (PLA), acrylonitrile-butadiene-styrene copolymer (ABS), etc., and polylactic acid is selected in this embodiment. After the printing is completed, the PLA microfluidic chip...

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Abstract

The invention discloses a pump-driving-free micro-fluidic chip manufacturing method based on three-dimensional printing. The pump-driving-free micro-fluidic chip manufacturing method comprises the steps that firstly, a three-dimensional model of a micro-fluidic chip substrate with channel grooves is designed; secondly, the micro-fluidic chip substrate with the channel grooves is printed out with printing software of a three-dimensional printer; thirdly, the side, with the channel grooves, of the printed micro-fluidic chip substrate is coated with a layer of a mixture of polydimethylsiloxane and a curing agent, and is dried; fourthly, paste is poured into the channel grooves and dried, and a pump-driving-free micro-fluidic chip based on three-dimensional printing is obtained. According to the pump-driving-free micro-fluidic chip manufacturing method based on three-dimensional printing, the processing process is simple, convenient and fast, the production efficiency is high, and industrial mass production is easy. The micro-fluidic chip prepared through the method can be recycled infinitely, and thus cost is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of microfluidic chips, in particular to a method for manufacturing a microfluidic chip with programmable non-drive speed based on 3D printing technology. Background technique [0002] Microfluidic chip, also known as lab-on-a-chip, is a technology that manipulates fluids on a micron scale. The technology shrinks the basic functions of chemical and biological laboratories onto a chip only a few square centimeters in size. Through the intersection of analytical chemistry, micro-electromechanical processing, computer, electronics, materials department, biology, medicine and other disciplines, the miniaturization, automation, integration and portability from sample processing to detection are realized. The microfluidic chip has the characteristics of flexible combination and large-scale integration of various unit technologies, so that a large amount of information can be obtained with a small amount of samples...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027
Inventor 贺永吴文斌傅建中高庆吴燕
Owner ZHEJIANG UNIV
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