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Preparation method of iron-chitosan metal supermolecular gel

A technology of supramolecular gel and chitosan, which is applied in the field of preparation of iron-chitosan gel and iron-chitosan metal supramolecular gel, can solve the problem that chitosan-iron supramolecular materials cannot Problems such as formation and disturbance of metal-supramolecular coordination, etc., to achieve excellent biological application prospects, simple preparation process, and extended application effects

Inactive Publication Date: 2016-06-08
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Probably due to the solubility product constant of ferric hydroxide (K SP ) lead to the precipitation of iron ions at lower pH conditions, thereby disrupting the metal-supramolecular coordination, resulting in the inability of the chitosan-iron supramolecular material to form

Method used

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  • Preparation method of iron-chitosan metal supermolecular gel
  • Preparation method of iron-chitosan metal supermolecular gel
  • Preparation method of iron-chitosan metal supermolecular gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Preparation of iron-chitosan supramolecular gel:

[0039] (1) Preparation of chitosan solution:

[0040] Add 1g of acetic acid to 100mL with water, then dissolve 1g of chitosan in the above solution, stir well and let it stand overnight for use.

[0041] (2) Preparation of iron-chitosan supramolecular gel:

[0042] Mix 100 μL 0.5M ferric nitrate aqueous solution and 800 μL chitosan solution under vigorous shaking to ensure that the iron ions and chitosan molecules are fully coordinated to form a coordination compound, and then quickly add 100 μL 0.4M hydrogen under vigorous shaking Sodium oxide solution was used to deprotonate chitosan molecules and trigger metal-supramolecular interactions between iron ions and chitosan molecules to form iron-chitosan supramolecular gels. After standing at room temperature for 24 hours, the iron-chitosan supramolecular gel was successfully formed.

[0043] figure 1 It is a macroscopic view of the iron-chitosan supramolecular gel...

Embodiment 2

[0056] 1. Preparation of iron-chitosan supramolecular gel:

[0057] (1) Preparation of chitosan solution:

[0058] Add 1 g of acetic acid to 100 mL of water, then dissolve 2 g of chitosan in the above solution, stir well and let stand overnight for use.

[0059] (2) Preparation of iron-chitosan supramolecular gel:

[0060] Mix 100 μL 0.7M ferric nitrate aqueous solution and 800 μL chitosan solution under vigorous shaking to ensure that the iron ions and chitosan molecules are fully coordinated to form a coordination compound, and then quickly add 200 μL 0.6M hydrogen under vigorous shaking Sodium oxide solution was used to deprotonate chitosan molecules and trigger metal-supramolecular interactions between iron ions and chitosan molecules to form iron-chitosan supramolecular gels. After standing at room temperature for 24 hours, the iron-chitosan supramolecular gel was successfully formed.

[0061] 2. Self-healing and pH-responsive behavior research

[0062] (1) A block-sh...

Embodiment 3

[0067] 1. Preparation of iron-chitosan supramolecular gel:

[0068] (1) Preparation of chitosan solution:

[0069] Add 1g of acetic acid to 100mL with water, then dissolve 4g of chitosan in the above solution, stir well and let it stand overnight for use.

[0070] (2) Preparation of iron-chitosan supramolecular gel:

[0071] Mix 100 μL 0.9M ferric nitrate aqueous solution and 800 μL chitosan solution under vigorous shaking to ensure that the iron ions and chitosan molecules are fully coordinated to form a coordination compound, and then quickly add 300 μL 0.8M hydrogen under vigorous shaking Sodium oxide solution was used to deprotonate chitosan molecules and trigger metal-supramolecular interactions between iron ions and chitosan molecules to form iron-chitosan supramolecular gels. After standing at room temperature for 24 hours, the iron-chitosan supramolecular gel was successfully formed.

[0072] 2. Self-healing and pH-responsive behavior research

[0073] (1) A block-...

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Abstract

The invention relates to a preparation method of iron-chitosan metal supermolecular gel and belongs to the field of biological functional material preparation. The method includes: preparing a chitosan solution; adding a ferric nitrate solution into the chitosan solution, mixing to form a stable iron-chitosan coordination compound, adding a NaOH solution under severe oscillation, and standing for 24 hours to allow coordination effect of the metal supermolecules to be brought into full play so as to obtain the stable and uniform iron-chitosan metal supermolecular gel. The iron-chitosan metal supermolecular gel prepared by the method has a self-healing function, is excellent in pH responsiveness and capable of sustainably releasing iron-chitosan coordination compounds, and can be hopefully used as an iron supplement agent to increase the effect of the iron supplement agent.

Description

technical field [0001] The invention belongs to the field of preparation of biological functional materials, and relates to a preparation method of iron-chitosan metal supramolecular gel, in particular to a method for forming iron-chitosan gel by utilizing the metal-supramolecular interaction of iron ions and chitosan Glue preparation method. Background technique [0002] Metal-supramolecular chemistry is based on a non-covalent interaction of metal-ligands, which are ubiquitous in natural organisms to build complex molecular structures and participate in the self-assembly of many natural materials. This unique dynamic reversible non-covalent interaction endows metallosupramolecular materials with excellent structural complexity, advanced functionality, and extended integration applications at molecular and inorganic levels. As a major component of organic polysaccharides, chitosan has excellent biocompatibility, biodegradability, antibacterial activity and hemostatic prope...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61K47/48A61K33/26A61K9/06A61P3/02
CPCA61K9/06A61K33/26C08G83/008
Inventor 潘建明吴润润朱恒佳黄伟姚俊彤
Owner JIANGSU UNIV
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