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Intermittent hypoxia method and application thereof in aspect of improving cognitive function

An intermittent and versatile technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, inorganic active ingredients, etc., can solve the problems that the effects have not been reported, and achieve the improvement of learning and memory ability, cognitive function, and dementia improvement Effect

Inactive Publication Date: 2016-06-15
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of intermittent hypoxia in the treatment of cognitive impairment or dementia has not been reported

Method used

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  • Intermittent hypoxia method and application thereof in aspect of improving cognitive function
  • Intermittent hypoxia method and application thereof in aspect of improving cognitive function
  • Intermittent hypoxia method and application thereof in aspect of improving cognitive function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] implement Example 1 Intermittent hypoxic system

[0023] The equipment includes an airtight hypoxic chamber, which contains an oxygen content monitoring device. The specific steps and conditions for use are as follows:

[0024] 1. When in use, put dementia model mice (APP / PS1 transgenic mice) and 6-month-old wild-type mice into a transparent animal hypoxic chamber for intermittent hypoxia. The humidity of the transparent animal experiment cabin was kept at 40-50%, and the temperature was kept at 22±2°C.

[0025] 2. Use parameters of the animal hypoxic chamber: at a speed of 10-20m / s, raise the simulated altitude in the chamber from 0m to 3000m in about 15 minutes (oxygen concentration: 16.2%; oxygen partial pressure: 106±35.2mmHg, PO2= 108.8mmHg), maintained for 4 hours, and then the simulated altitude was dropped from 3000m to 0m, and the animals were taken out and raised under normal conditions.

[0026] 3. Intermittent hypoxic time: the animals were exposed to 30...

Embodiment 2

[0027] Example 2 Intermittent Hypoxia Improves Cognitive Function in Dementia Mice

[0028] The classic Morris water maze test was used to evaluate the learning and memory ability of mice, and the specific steps were as follows: The Morris water maze test was divided into two parts: the hidden platform acquisition test for 5 consecutive days and the space exploration test on the 6th day. The water maze experimental device is mainly composed of a circular pool with a diameter of 120cm and a height of 50cm. The pool is divided into 4 quadrants. A circular hidden platform with a diameter of 9cm and a height of 27cm is placed in the center of the target quadrant. The platform is located on the water surface 1cm down, its position remained unchanged throughout the experiment, and the water temperature was 22°C-24°C. The maze is surrounded by a white curtain, and a reference object is set on the curtain, and the position of the reference object remains unchanged during the experimen...

Embodiment 3

[0033] Example 3 Intermittent hypoxia reduces the number of senile plaques in dementia mice

[0034] Using immunohistochemical staining to observe the effect of intermittent hypoxia on the number of senile plaques in dementia mice, the specific steps are as follows:

[0035] 1. Mouse perfusion and brain tissue fixation: Nembarbital sodium (60mg / kg, i.p.) anesthetizes the mouse intraperitoneally, cuts the abdominal skin and ribs of the mouse, opens its chest cavity, a beating heart can be seen, and inserts the needle for perfusion Cut the left ventricle of the mouse, cut the right atrium quickly, and perfuse it with pre-cooled heparinized (containing 0.02% heparin sodium) saline for 5 minutes. After the heart and liver turn white, then use pre-cooled 4% paraformaldehyde After perfusion for 10 minutes, the brain tissue was taken out and soaked in 4% paraformaldehyde containing 15% sucrose for 24 hours, then replaced with 0.01MPBS solution containing 30% sucrose, and placed at 4°C ...

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Abstract

The invention discloses the use of intermittent hypoxia in improving cognitive function. Intermittent hypoxia is to give oxygen in the form of hypoxia-normal oxygen alternately. The time of hypoxia is 2-6 hours, and the oxygen partial pressure is 70.8-141.2mmHg; the time of normoxia is 18-22 hours, and the oxygen partial pressure For: 140.8-181.2mmHg; continuous treatment for 7-42 days. The intermittent hypoxia scheme of the present invention can be used to improve the cognitive function of mammals, improve the ability of learning and memory, and treat cognitive dysfunction and senile dementia of mammals.

Description

technical field [0001] The invention relates to a method for improving cognitive ability, in particular to an intermittent hypoxia method and its application in improving cognitive function. Background technique [0002] Dementia is a syndrome of chronic acquired progressive mental retardation, usually accompanied by impairment of cognitive function, occasionally with the decline of emotional control and social behavior as prodromal symptoms. Mild cognitive impairment (mildcognitive impairment, MCI) specifically refers to the decline of memory or cognitive function but does not meet the standard of dementia. ) is 10 times that of normal people, therefore, MCI is considered to be a transitional stage from aging to dementia. [0003] According to the international classification of dementia, it mainly includes: 1. Alzheimer's disease (Alzheimer's Disease, AD) is a degenerative disease of the central nervous system accompanied by cognitive, behavioral and functional abnormalit...

Claims

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Application Information

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IPC IPC(8): A61G10/02A61K33/00A61P25/28
CPCA61G10/02A61K33/00
Inventor 黄欣乔萌周延召赵彤吴丽颖朱玲玲范明
Owner INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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