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Production method of improving dissolubility of pipe cone clear ointment

A production method and the technology of pine cones, which are applied in the production field of improving the solubility of pine cone clear paste, can solve the problems of reduced solubility of extract dry powder, long standing filtering time, and reduced drug effectiveness, so as to shorten the production cycle, The effect of low cost and shortened time

Active Publication Date: 2016-06-15
ZHONGXING PHARM CO LTD JIANGSU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

High-quality extract dry powder has good solubility, but due to long-term production, there are impurities in the air, which will remain in the pipeline and enter the drying tower to pollute the dry extract powder, affecting product quality and causing the produced dry extract powder to dissolve decreased sex
[0003] At present, the processing steps for the pine cone clear paste are as follows: decoct the pine cone with water twice, each time for 2 to 3 hours, combine the decoction, let it stand for precipitation and filter, and then take the supernatant and concentrate it to a relative density of 1.23 to 1.23. 1.25 to get clear ointment, but due to the relatively long time of standing and filtering, traditional high-temperature concentration is prone to scorch, which reduces the effectiveness of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 The present embodiment discloses a method for improving the solubility of Songtaqing ointment, comprising the steps of:

[0016] (1) put the pine cone to be processed into a hot air circulation oven and dry at 90°C for 2 hours;

[0017] (2) decocting the dried pine cone, adding 2 times the water of the dried pine cone to decoct during decoction, decocting twice, each time for 2-3 hours, and then combining the decoction to obtain the decoction, The decoction is vacuum filtered through a 400-mesh filter cloth;

[0018] (3) The filtrate is sprayed and concentrated by two-stage vacuum heating, the vacuum degree is set to -0.05MPa, the aperture of the nozzle is 100 mesh, and the temperature is 90°C. After each stage of vacuum heating, spraying and concentration, the formed clear paste is collected. The filtrate that has not been made into a clear paste enters the next stage of vacuum heating and spraying concentration. After the first stage of vacuum heating, s...

Embodiment 2

[0020] The method of this embodiment is basically the same as that of Example 1. The difference is that in order to remove impurities in the liquid medicine as much as possible, flocculation and precipitation are carried out before vacuum filtration with a 400-mesh filter cloth. The step of flocculation and precipitation is: adjust the pH of the liquid medicine Be 7, stir, when temperature is 60 ℃, add chitosan, the amount that chitosan adds is the chitosan corresponding to 0.005g per gram of dried pine cone, continues to stir to make whole system become flocculation system, then to The material is left to stand; after standing for 24 hours to clarify, take the supernatant and filter to obtain the decoction after flocculation and precipitation.

Embodiment 3

[0021] Embodiment 3 This embodiment discloses a method for improving the solubility of Songtaqing ointment, comprising the steps of:

[0022] (1) Put the pine cone to be processed into a hot air circulation oven and dry it at 85°C for 2 hours;

[0023] (2) decocting the dried pine cone, adding 2 times the water of the dried pine cone to decoct during decoction, decocting twice, each time for 2-3 hours, and then combining the decoction to obtain the decoction, The decoction is vacuum filtered through a 400-mesh filter cloth;

[0024] (3) The filtrate is sprayed and concentrated by two-stage vacuum heating, the vacuum degree is set to -0.1MPa, the aperture of the nozzle is 100 mesh, and the temperature is 85°C. After each stage of vacuum heating, spraying and concentration, the formed clear paste is collected. The filtrate that has not been made into a clear paste enters the next stage of vacuum heating and spraying concentration. After the first stage of vacuum heating, sprayi...

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PUM

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Abstract

The invention discloses a production method of improving dissolubility index of pipe cone clear ointment, comprising the following steps: (1), placing pipe cones to be treated into a hot air circulating oven and drying at 85-90 DEG C for 2-3 hours; (2), decocting the dried pipe cones, collecting and filtering supernate to obtain filtrate, filtering the filtrate to remove precipitate, and vacuum suck-filtering decoction with 400-mesh filter cloth; (3), vacuum heating, sprinkling and concentrating suction filtrate to obtain required finished clear ointment.The pipe cones to be decocted are dried at 85-90 DEG C, the molecular structure of wax on the surfaces of the pipe cones is broken, and the influence of the wax upon the dissolubility of the clear ointment is eliminated; through vacuum suction filtering with the 400-mesh filter cloth, standing time for impurity removal is greatly shortened and production cycle is shortened, and in addition, the cost is low and the effect is good; a vacuum heating, sprinkling and concentrating apparatus not only prevents coke breeze occurring in conventional high-temperature concentrating and improves effectiveness of a medicament, but also is simple to operate and widely applicable, with conditions easy to control.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparation, and in particular relates to a production method for improving the solubility of Songtaqing ointment. Background technique [0002] In the production of pharmaceuticals, drying technology is usually used to process the extract into dry powder according to the needs. The drying technology usually adopts spray drying technology. Its application in the field of traditional Chinese medicine continues to expand and plays an important role. The drying principle is usually: decoction The liquid is heated to the corresponding required temperature, and supplied to the centrifugal atomizer located on the top of the drying tower through the material pump, and the extract is atomized into the corresponding required liquid droplets by high-speed centrifugation, and sprayed into the drying tower evenly. The hot air conducts large-area convective contact, completes drying and molding inst...

Claims

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Application Information

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IPC IPC(8): A61K36/15A61K9/06A61K47/36
CPCA61K9/06A61K36/15A61K47/36A61K2236/17A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 武俊明付廷明吴春芳
Owner ZHONGXING PHARM CO LTD JIANGSU