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Glass wound repair gel with biological activity and preparation method thereof

A bioactive glass and wound repair technology, applied in medical science, bandages, etc., can solve problems such as increased medical expenses, patient appearance and mental impact, poor healing effect, etc., to reduce the temperature, inhibit the growth of scars, good stability effect

Inactive Publication Date: 2016-06-29
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In daily life, chronic large area wounds such as burns, cuts, decubitus, diabetic foot and various skin surface ulcers cause dermal trauma, not only the healing effect is poor, the cycle is long, and due to the proliferation of fibroblasts, hypertrophic scars are formed , It is extremely difficult to recover in a short period of time, causing serious appearance and mental impact to the patient, and also greatly increasing the medical expenses

Method used

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  • Glass wound repair gel with biological activity and preparation method thereof
  • Glass wound repair gel with biological activity and preparation method thereof
  • Glass wound repair gel with biological activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A wound repair gel containing bioactive glass, which consists of the following components in parts by weight: 10 parts of bioactive glass powder, 2 parts of polyethylene glycol 400, 10 parts of silica gel, 5 parts of sodium hyaluronate Glue, 0.1 part of acid granules, 0.5 part of borneol, 0.1 part of absolute ethanol. The pH of the bioactive glass-containing wound repair gel is 6-7.

[0036] A preparation method of a bioactive glass-containing wound repair gel, the specific process steps are as follows:

[0037] S1. Disperse the bioactive glass powder in polyethylene glycol 400, sonicate for 20-40 minutes at 25-50°C, and then stir evenly to prepare a solution A. The bioactive glass is evenly dispersed in polyethylene glycol 400. In alcohol 400, a uniform suspension is formed;

[0038] S2. Dissolving the borneol in absolute ethanol, stirring for 5-20 minutes until dissolved, then adding the acidic particles, stirring for 5-20 minutes, to prepare a B solution;

[0039]...

Embodiment 2

[0046] A wound repair gel containing bioactive glass, which consists of the following components in parts by weight: 25 parts of bioactive glass powder, 5 parts of polyethylene glycol 400, 15 parts of silica gel, 10 parts of sodium hyaluronate Glue, 1 part of acid granules, 2.5 parts of borneol, 0.25 parts of absolute ethanol. The pH of the bioactive glass-containing wound repair gel is 6-7.

[0047] A preparation method of a bioactive glass-containing wound repair gel, the specific process steps are as follows:

[0048] S1. Disperse the bioactive glass powder in polyethylene glycol 400, sonicate for 20-40 minutes at 25-50°C, and then stir evenly to prepare a solution A. The bioactive glass is evenly dispersed in polyethylene glycol 400. In alcohol 400, a uniform suspension is formed;

[0049] S2. Dissolving the borneol in absolute ethanol, stirring for 5-20 minutes until dissolved, then adding the acidic particles, stirring for 5-20 minutes, to prepare a B solution;

[005...

Embodiment 3

[0057] A wound repair gel containing bioactive glass, which consists of the following components in parts by weight: 40 parts of bioactive glass powder, 10 parts of polyethylene glycol 400, 25 parts of silica gel, 15 parts of sodium hyaluronate Glue, 2 parts of acid granules, 5 parts of borneol, 0.5 parts of absolute ethanol. The pH of the bioactive glass-containing wound repair gel is 6-7.

[0058] A preparation method of a bioactive glass-containing wound repair gel, the specific process steps are as follows:

[0059] S1. Disperse the bioactive glass powder in polyethylene glycol 400, sonicate for 20-40 minutes at 25-50°C, and then stir evenly to prepare a solution A. The bioactive glass is evenly dispersed in polyethylene glycol 400. In alcohol 400, a uniform suspension is formed;

[0060] S2. Dissolving the borneol in absolute ethanol, stirring for 5-20 minutes until dissolved, then adding the acidic particles, stirring for 5-20 minutes, to prepare a B solution;

[0061...

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Abstract

The invention belongs to the field of medical dressings, and particularly relates to glass wound repair gel with biological activity and a preparation method thereof. The gel is prepared from, by weight, 10-40 parts of biological activity glass powder, 2-10 parts of polyethylene glycol 400, 10-25 parts of silica gel, 5-15 parts of sodium hyaluronate gel, 0.1-2 parts of acid particles, 0.5-5 parts of borneol and 0.1-0.5 part of absolute ethyl alcohol. The gel has remarkable treatment effects on treatment of chronic large-area wounds of empyrosis, pressure sores, diabetic feet, contusion, various skin surface anabrosis and the like, and meanwhile the gel has the special effects of preventing adhesion, resisting bacteria, preserving moisture, restraining scar growth and the like.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to a bioactive glass-containing wound repair gel and a preparation method thereof. Background technique [0002] Bioactive glass has good bioactivity and biocompatibility, can activate the expression of genes related to wound healing, promote the proliferation and differentiation of fibroblasts, accelerate the formation of blood vessels, promote the growth of granulation tissue, and promote the formation of hard and soft tissues. Repair and regeneration, promote wound healing. The mechanism of bioactive glass to promote wound healing is as follows: (1) Under the action of body fluid, Na + , Ca 2+ Such active ions as H in body fluid + Enter the glass surface to form Si-OH-; (2) Due to the destruction of the Si-O-Si bond, the random network is dissolved, and the soluble silicon is released in the form of silanol, and quickly forms a hydroxyapatite cement on the surface ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0004A61L26/0023A61L2300/10A61L2300/20A61L2300/402A61L2300/412
Inventor 卢亢陈锦涛李婷
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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