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Multivitamin pellet containing 5-methyltetrahydrofolate

A technology of methyltetrahydrofolate and multivitamins, which is applied to medical preparations containing active ingredients, microcapsules, drug combinations, etc., can solve the problems of complex production process, unsatisfactory effect, and content decline, and achieve simple production process , High reproducibility, fast dissolution effect

Active Publication Date: 2016-07-13
FERGUSON WUHAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The stability of 5-methyltetrahydrofolate and vitamin B6 and vitamin B12 is very poor, and high temperature, high humidity, light, and oxidation all easily lead to a decrease in the content. The existing 5-methyltetrahydrofolate preparations usually use the addition of protective agents, Antioxidants, or inclusion or microencapsulation of unstable components to improve their stability, but these methods are not only complicated in production process, but also unsatisfactory

Method used

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  • Multivitamin pellet containing 5-methyltetrahydrofolate
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A multivitamin pellet containing 5-methyltetrahydrofolate, made from the following raw materials:

[0021]

[0022]

[0023] The preparation method is as follows:

[0024] 1) Pill making: 5-methyltetrahydrofolate, vitamin B6, and vitamin B12 are dissolved together in 200ml80% ethanol solution to obtain a drug-containing solution; microcrystalline cellulose is made into a blank ball core by a conventional process, and then in fluidized The drug-containing solution is sprayed on the blank ball core in the bed to apply the drug, and the drying temperature is controlled to be 35-40° C. when applying the drug.

[0025] When making pills, the amount, concentration and drying temperature of ethanol have a great influence on the quality of the ball core. When the ethanol concentration is low or the amount is large, the water content of the ball core is high, and it is easy to cause 5-methyltetrahydrofolate and vitamin High or low ethanol concentration will increase the h...

Embodiment 2

[0030] A multivitamin pellet containing 5-methyltetrahydrofolate, made from the following raw materials:

[0031]

[0032]

[0033] The preparation method is as follows:

[0034] 1) Pill making: Povidone K30 is dissolved in 70% aqueous ethanol to obtain a mass concentration of 5% Povidone K30 solution, then 5-methyltetrahydrofolate, vitamin B6, and vitamin B12 are added to povidone In the K30 solution, stir to dissolve; stir and mix lactose and sucrose powder, add the povidone K30 solution dissolved in the main ingredient, stir to make a soft material, and then use the extrusion-spheronization method to make the soft material into pellets, Obtain ball core after drying;

[0035] 2) coating: methyl cellulose, acrylic acid resin, and zein are dissolved in 80% ethanol aqueous solution respectively, obtain the coating liquid that mass concentration is respectively 3%, 4%, 2%, spray in the fluidized bed then Add the above three coating solutions, first spray into the methyl...

Embodiment 3

[0038] A multivitamin pellet containing 5-methyltetrahydrofolate, made from the following raw materials:

[0039]

[0040]

[0041] The preparation method is as follows:

[0042] 1) Pill making: hydroxypropyl methylcellulose is dissolved in 80% aqueous ethanol to obtain a mass concentration of 3% hydroxypropyl methylcellulose solution, and then 5-methyltetrahydrofolate, vitamin B6, Vitamin B12 is added to the hydroxypropyl methylcellulose solution, stirred and dissolved; the starch is taken, added to the hydroxypropyl methylcellulose solution dissolved in the main ingredient, and stirred to make a soft material, and then the soft material is extruded- The pellets are made by spheronization, and the pellet cores are obtained after drying;

[0043] 2) Coating: Dissolve gelatin, acrylic resin, and paraffin in 80% ethanol aqueous solution respectively to obtain coating solutions with mass concentrations of 1%, 5%, and 2%, and then spray the above-mentioned three kinds into ...

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Abstract

The invention belongs to the field of pharmaceutical preparation and discloses a multivitamin pellet containing 5-methyltetrahydrofolate.The multivitamin pellet consists of a pellet core and a coating, and the diameter of the multivitamin pellet is 200-400 micrometers.The multivitamin pellet comprises, by unit dose, 0.3-0.8mg of folic acid, 1-2mg of vitamin B, 1.5-2microgram of vitamin B12, 80-120mg of an excipient and 6-10mg of a coating agent.The multivitamin pellet containing the 5-methyltetrahydrofolate has the advantages that stability of main ingredients under conditions of high temperature, high humidity and high light can be evidently improved, and accordingly medicine validity period is prolonged.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound vitamin pellet containing 5-methyltetrahydrofolate. Background technique [0002] 5-Methyltetrahydrofolate is the main form of tissue or blood folic acid and participates in many important biochemical reactions in the body. Pregnant women taking vitamin B supplementation while taking 5-methyltetrahydrofolate 6 and vitamin B 12 It has the functions of preventing fetal neural tube defects, arteriosclerosis, and treating megaloblastic anemia. [0003] The stability of 5-methyltetrahydrofolate and vitamin B6 and vitamin B12 is very poor, and high temperature, high humidity, light, and oxidation all easily lead to a decrease in the content. The existing 5-methyltetrahydrofolate preparations usually use the addition of protective agents, Antioxidants, or inclusion or microencapsulation of unstable components to improve their stability, but these methods are not ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K9/50A61P25/00A61P9/10A61P7/06A61K31/519A61K31/4415
CPCA61K9/5047A61K9/5057A61K9/5073A61K31/4415A61K31/519A61K31/714A61K2300/00
Inventor 黄飞赵小伟欧阳康乐
Owner FERGUSON WUHAN BIOTECH
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