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A traditional Chinese medicine preparation for preventing and treating osteoporosis and its preparation method

A technology of osteoporosis and traditional Chinese medicine preparations, applied in the field of traditional Chinese medicine, can solve problems such as side effects and negative impact on patients' lives, and achieve the effects of small toxic and side effects, significant curative effect, and high safety factor

Active Publication Date: 2019-06-28
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the curative effect is definite, long-term use is prone to cause various side effects, which will bring great negative impact on the life of patients

Method used

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  • A traditional Chinese medicine preparation for preventing and treating osteoporosis and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] API:

[0024] 32 parts of Epimedium, 24 parts of Sangji, 18 parts of Achyranthes bidentata, 20 parts of Corydalis, 15 parts of Ligustrum lucidum, 12 parts of woody fragrance, 12 parts of angelica, 15 parts of Atractylodes atractylodes, 15 parts of sea octopus;

[0025] The preparation method is:

[0026] (1) Weighing Chinese medicinal materials according to the parts by weight of the crude drug, and selecting them;

[0027] (2) The squid octopus is crushed into fine powder, passed through a 200-mesh sieve, and set aside;

[0028] (3) Add epimedium, mulberry, Achyranthes bidentata, corydalis, Ligustrum lucidum, woody, angelica, atractylodes, add 10 times the amount of water, heat and decoct 3 times, 2.5 hours each time, filter, combine the filtrate, concentrate To one-half of the volume of the filtrate, add 95% ethanol until the alcohol content is 75%, let it stand for 24 hours, centrifuge, take the supernatant, filter, concentrate the filtrate under reduced pressure t...

Embodiment 2

[0031] API:

[0032] 30 parts of Epimedium, 20 parts of Sangji, 15 parts of Achyranthes bidentata, 18 parts of Corydalis, 18 parts of Ligustrum lucidum, 10 parts of woody fragrance, 18 parts of angelica, 20 parts of Atractylodes atractylodes, 10 parts of sea octopus;

[0033] The preparation method is:

[0034] (1) Weighing Chinese medicinal materials according to the parts by weight of the crude drug, and selecting them;

[0035] (2) Pulverized squid octopus into fine powder, passed through a 300-mesh sieve, and set aside;

[0036] (3) Add Epimedium, Sangjisi, Achyranthes bidentata, Corydalis, Ligustrum lucidum, Woody Fragrance, Angelica, Atractylodes atractylodes, add 11 times the amount of water, heat and decoct 3 times, 3 hours each time, filter, combine the filtrate, concentrate To one-half of the volume of the filtrate, add 95% ethanol until the alcohol content is 70%, let it stand for 30 hours, centrifuge, take the supernatant, filter, concentrate the filtrate under r...

Embodiment 3

[0039] API:

[0040] 25 parts of Epimedium, 18 parts of Sangji, 15 parts of Achyranthes bidentata, 15 parts of Corydalis, 10 parts of Ligustrum lucidum, 10 parts of woody fragrance, 15 parts of Angelica sinensis, 10 parts of Atractylodes atractylodes, 12 parts of sea octopus;

[0041] The preparation method is:

[0042] (1) Weighing Chinese medicinal materials according to the parts by weight of the crude drug, and selecting them;

[0043] (2) The squid octopus is crushed into fine powder, passed through a 200-mesh sieve, and set aside;

[0044] (3) Add epimedium, mulberry, Achyranthes bidentata, corydalis, Ligustrum lucidum, woody, angelica, atractylodes, add 9 times the amount of water, heat and decoct 3 times, 3 hours each time, filter, combine the filtrate, concentrate To one-half of the volume of the filtrate, add 95% ethanol until the alcohol content is 65%, let it stand for 36 hours, centrifuge, take the supernatant, filter, concentrate the filtrate under reduced pres...

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Abstract

The invention provides a traditional Chinese medicine preparation for preventing and treating osteoporosis and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared by water extraction and alcohol precipitation of herba epimedii, herba taxilli, achyranthes bidentata blume, corydalis tuber, glossy privet fruits, costustoot, angelica sinensis, rhizoma atractylodis and cuttlebone, wherein the herba epimedii and the herba taxilli are used for tonifying the liver and kidneys and are monarch medicines; the achyranthes bidentata blume and the corydalis tuber are used for activating blood circulation to promote menstruation, regulating qi and relieving pain and are minister medicines; the glossy privet fruits, the costustoot, the angelica sinensis, the rhizoma atractylodis and the cuttlebone are used for nourishing yin, tonifying the spleen, enriching the blood and regulating qi as assistant medicines; the traditional Chinese medicine preparation has a significant curative effect on osteoporosis, is small in toxic or side effect and high in safety coefficient, and is capable of obviously improving thebone mineral density and the bone strength of a patient after being taken for a long period of time.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for preventing and treating osteoporosis and a preparation method thereof, belonging to the field of traditional Chinese medicine application. Background technique [0002] Osteoporosis is a common degenerative disease in the elderly and a frequent disease in postmenopausal women. The causes of the disease are complex and diverse. Pathologically, it is characterized by osteopenia, changes in the microstructure of bone tissue, thinning, fracture, and reduced number of cancellous bone trabeculae, and porous and thinning of cortical bone. . Clinically, the main manifestations are general bone pain, spinal deformity and even fracture. At present, Western medicines for preventing osteoporosis mainly include estrogen, calcitonin, calcium preparations and vitamin D drugs. Although the curative effect is definite, long-term use is easy to cause various side effects, which brings great negat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P19/10A61K35/618
CPCA61K35/618A61K36/185A61K36/21A61K36/232A61K36/284A61K36/285A61K36/296A61K36/638A61K36/66A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 杨柳姜海
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE