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Cornea protecting composition as well as preparation method and application thereof

A composition and cornea technology, applied in medical science, surgery, etc., can solve the problems of reducing the number of particles, the number of colonies, and the content of endotoxin, the cleanliness is not easy to meet the requirements for surgery, and transportation and storage need to be refrigerated, etc., to achieve good results. Protection, reduced transportation and use costs, and short preparation cycle

Active Publication Date: 2016-07-13
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the raw material cost of sodium hyaluronate and chitosan is high; and the product is unstable at high temperature, and transportation and storage need to be refrigerated; the means of reducing the number of particles, the number of colonies and the content of endotoxin cannot be used on these substances, making them The cleanliness is not easy to meet the requirements for surgical use
[0006] Although the prior art discloses a variety of eye products containing moisturizing and lubricating ingredients, there is still no product that can simultaneously meet the following conditions: good moisturizing and lubricating performance, good dispersion on the corneal surface, stable component properties, and bacterial colonization. Number, particle number, and endotoxin content are all easy to meet the requirements for surgical use

Method used

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  • Cornea protecting composition as well as preparation method and application thereof
  • Cornea protecting composition as well as preparation method and application thereof
  • Cornea protecting composition as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1-10

[0043] Embodiment 1-10, the composition of preparation corneal protection

[0044] The formulations of the compositions for protecting the cornea of ​​Examples 1-10 of the present invention and Comparative Examples are shown in Table 1-2. Comparative Example 1 is a product prepared according to the method in CN102225220A, Comparative Example 2 is a product prepared according to the method in TWI290050B, Comparative Examples 3 and 4 are products prepared according to the method in CN104083396A, Comparative Examples 5 and 6 are According to the product prepared by the formula and method of the present invention, only the solid moisturizing and lubricating components are not within the numerical range of the present invention.

[0045] The composition of table 1 embodiment 1-5 protection cornea and the formula of comparative example 1-3 (the quality of each component in the composition of every 1000g protection cornea)

[0046]

[0047]

[0048] The composition of table 2 ...

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Abstract

The invention discloses cornea protecting composition as well as a preparation method and an application thereof. Main components of the composition comprise a solid moisturizing and lubricating component, a liquid moisturizing and lubricating component, an osmoregulation component and water. The composition adopts double moisturizing and lubricating components including the solid moisturizing and lubricating component and the liquid moisturizing and lubricating component, so that the composition can be better spread and remained on the corneal surface and better protect the corneal epithelial layer, and damage caused by dryness to the cornea can be avoided. For a preparation process of the composition, a solution is not required to be heated to boiling, preparation operation is simpler, a preparation cycle is shorter than 48 h, cold storage is not needed during transportation and storage, and the transportation cost and use cost are reduced.

Description

technical field [0001] The invention relates to the technical field of medical supplies for ophthalmic surgery, in particular to a composition for protecting the cornea and its preparation method and application. Background technique [0002] During eye examinations and eye surgery, the cornea is exposed to the outside world, loses the protection of tears, and can be damaged by drying. Most current clinical solutions are the frequent use of saline or commercially available viscoelastics on the corneal surface during examination and surgery. However, due to the short residence time of normal saline on the corneal surface, it needs to be used frequently, which makes the operation interrupted and brings inconvenience to clinicians. In addition, excessive use of normal saline will cause eye swelling and discomfort to patients. However, the viscoelastic agent has poor dispersibility on the surface of the cornea due to its viscosity, and cannot quickly form a protective layer. It...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14A61L31/16
CPCA61L31/128A61L31/14A61L31/16
Inventor 任芳王月月
Owner SAIKE SAISI BIOTECH CO LTD
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