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Aspirin pharmaceutical composition and application thereof in biological medicine

A technology of aspirin and composition, which is applied in the field of pharmaceutical composition and its application in biomedicine, can solve problems such as no related reports, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-07-13
陈昊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between aspirin and its pharmaceutical composition and acute lung injury

Method used

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  • Aspirin pharmaceutical composition and application thereof in biological medicine
  • Aspirin pharmaceutical composition and application thereof in biological medicine
  • Aspirin pharmaceutical composition and application thereof in biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Separation method: (a) Crush the aconite (2kg), extract with 90% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and successively use petroleum ether (3L×3 times) , ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) Use D101 macroporous resin to remove impurities from the ethyl acetate extract, first elute with 35% ethanol for 8 column volumes, then use 90% ethanol for 12 column volumes, collect 90% of the eluate, and concentrate under reduced pressure to obtain 90% ethanol elution concentrate; (c) 90% ethanol elution concentrate in step (b) is separated with normal phase silica gel, and the volume ratio is 120:1 (11 column volumes), 60:1 (9 column volumes) successively column volume), 30:1 (9 ...

Embodiment 2

[0024] Embodiment 2: pharmacological action

[0025] 1. Materials and methods

[0026] 1.1 Animals

[0027] Healthy male clean-grade SD rats with a body weight of 320-370 g (provided by the Animal Experiment Center of Nanjing Military Region General Hospital) were selected. The animals were kept in a ventilated and dry environment with a temperature of (22±1)°C, a relative humidity of 55%-65%, and a 12-h light cycle, and were fed with maintenance diet 1022 for rats and mice.

[0028] 1.2 Reagents and samples

[0029] Aspirin was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Rat tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), enzyme-linked immunosorbent assay (ELISA) detection kits were purchased from Biosource International, USA Company; Rat HMGB1 ELISA detection kit was purchased from Japan Shino-Test Company. H...

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PUM

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Abstract

The invention discloses an aspirin pharmaceutical composition and application thereof in biological medicine.The aspirin pharmaceutical composition is prepared from aspirin and a natural product compound (I) of a novel structure.The composition of aspirin and the compound (I) can remarkably reduce lung injury caused by septicopyemia, has a better effect than that achieved when aspirin or the compound (I) acts alone, can be developed into medicine for treating acute lung injury, and has the outstanding substantive features and achieves a remarkable progress compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of aspirin, in particular to a pharmaceutical composition of aspirin and its application in biomedicine. Background technique [0002] Aspirin is an antipyretic and analgesic with a long history. Modern pharmacological research has found that it also has various other effects. [0003] The pathogenesis of acute lung injury (ALI) has not yet been fully elucidated. Studies have found that uncontrolled inflammatory response plays an important role in the pathogenesis of ALI. Advances in antibiotics and supportive measures have not reduced patient mortality, so new drug interventions are urgently needed. ALI is the manifestation of systemic inflammatory response syndrome in the lungs, and the imbalance between inflammatory response and anti-inflammatory response in the lung is the root cause of ALI / ARDS. [0004] So far, there is no report on the correlation between aspir...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/56A61K31/616A61P11/00
CPCC07J63/008A61K31/56A61K31/616
Inventor 陈昊
Owner 陈昊