Application of forsythiagenin in the preparation of drugs for preventing or treating liver fibrosis

A technology for forsythia aglycone and liver fibrosis, which is applied in the field of medicine and achieves the effects of good safety, reducing the degree of tissue fibrosis and reducing the level of tissue fibrosis.

Active Publication Date: 2018-07-06
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, there are no records and reports about the preventive and / or therapeutic effects of forsythiagenin on liver fibrosis in the prior art

Method used

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  • Application of forsythiagenin in the preparation of drugs for preventing or treating liver fibrosis
  • Application of forsythiagenin in the preparation of drugs for preventing or treating liver fibrosis
  • Application of forsythiagenin in the preparation of drugs for preventing or treating liver fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Forsythin injection

[0025]

[0026] Preparation process: mix the prescription amount of propylene glycol and ethanol uniformly, add forsythia aglycone, stir to dissolve, add the prescription amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for injection, stir, and decarbonize to get .

Embodiment 2

[0027] Example 2 Forsythin injection

[0028]

[0029] Preparation process: add forsythia aglycin to the polyethylene glycol-400 of the prescription, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to obtain.

Embodiment 3

[0030] Example 3 Forsythin Injection

[0031]

[0032] Preparation process: mix the prescription amount of ethanol and Tween-80 uniformly, add forsythia aglycone, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to get.

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PUM

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Abstract

The invention relates to an application of fructus forsythiae aglycone in preparation of medicines for preventing or treating hepatic fibrosis, which belongs to the field of medicine. The fructus forsythiae aglycone is a traditional Chinese medicine monomer obtained by extracting from the conventional fructus forsythiae, and is shown to have better treatment effect for hepatic fibrosis according to an animal test, can improve serum protein and transaminase levels, reduces liver Hyp content, reduces the level of four indicators of hepatic fibrosis, reduces liver weight, and reduces fibrous hyperplasia. The effect of fructus forsythiae aglycone for treating hepatic fibrosis is better than that of a fructus forsythiae extract product and fructus forsythiae. The fructus forsythiae aglycone is exact in curative effect and low in side effect for treating hepatic fibrosis, and has wide medical application prospect.

Description

Technical field [0001] The invention belongs to the field of medicine, and relates to a medicinal use of forsythin, in particular to the medicinal use of forsythin in the preparation of drugs for preventing or treating liver fibrosis. Background technique [0002] Liver fibrosis refers to the excessive deposition of diffuse extracellular matrix (especially collagen) in the liver. It is a damage repair response of the body to chronic liver injury caused by various etiologies. It is manifested by abnormal proliferation of collagen fibers in the liver. Cell degeneration and necrosis, the structure and function of liver tissue are destroyed, resulting in abnormal liver function, affecting the prognosis of liver disease. If liver fibrosis is not treated in time, it may progress to decompensated liver cirrhosis and various end-stage liver disease complications. Liver cirrhosis and its complications have become the main cause of morbidity and death worldwide. Liver fibrosis is a lot of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/34A61P1/16
Inventor 张贵民王恩力李光艳孙敬侠曹政霞
Owner LUNAN PHARMA GROUP CORPORATION
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