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Poultry medicine taking chitosan as carrier and preparation method of poultry medicine

A technology of chitosan and poultry medicine, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of increasing the difficulty and cost of clinical medication, the failure of antibiotics and chemical antibacterial drugs, The benefits of farmers cannot be guaranteed, etc., to achieve the effect of increasing drug loading rate, high product quality, and short production cycle

Inactive Publication Date: 2016-08-10
山东锐基生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing problems exist in China's domestic poultry breeding industry: firstly, the traditional agricultural breeding methods are deeply rooted, and modern mechanized agriculture is advancing slowly; The threat of diseases such as epidemic and E. coli infection makes farmers have to be cautious in the choice of poultry farming, and the interests of farmers cannot be guaranteed. The above problems affect the development of poultry farming in my country to a large extent.
[0004] At present, with the continuous improvement of the intensification of the poultry farming industry, infectious bronchitis, avian influenza, Newcastle disease, Escherichia coli infection and other disease pathogens of poultry are often mixed with infection, which complicates or atypical the clinical symptoms; antibacterial in feed additives The application of drugs has led to the emergence of a large number of drug-resistant strains, and many antibiotics and chemical antibacterial drugs are increasingly ineffective; public health and food safety issues have become increasingly prominent, which has increased the difficulty and cost of clinical medication

Method used

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  • Poultry medicine taking chitosan as carrier and preparation method of poultry medicine
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Examples

Experimental program
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Effect test

Embodiment 1

[0036] A preparation method using chitosan as a carrier poultry medicine, comprising the following steps: the first step: preparation of high-strength chitosan microspheres; second step: preparation of chitosan microporous drug-loaded microspheres,

[0037] The first step: the preparation process of high-strength chitosan microspheres is as follows:

[0038] (1) Prepare acetic acid + citric acid + ascorbic acid solution, wherein the volume ratio of acetic acid, citric acid, and ascorbic acid is 0.5:0.3:0.1, take 1g of acetic acid + citric acid + ascorbic acid solution and dilute it to a mass fraction of 1% acetic acid + lemon Acid + ascorbic acid solution, denoted as A; 5g of sodium polyphosphate was dissolved in 100ml of deionized water, and the pH value was adjusted to 4-6 to obtain a 5% sodium polyphosphate solution; 5g of sodium hydroxide was dissolved in 100ml The sodium hydroxide solution with a mass fraction of 5% in deionized water is used for later use; (2) Chitosan w...

Embodiment 2

[0042] A preparation method using chitosan as a carrier poultry medicine, comprising the following steps: the first step: preparation of high-strength chitosan microspheres; second step: preparation of chitosan microporous drug-loaded microspheres,

[0043] The first step: the preparation process of high-strength chitosan microspheres is as follows:

[0044] (1) Prepare acetic acid + citric acid + ascorbic acid solution, wherein the volume ratio of acetic acid, citric acid, and ascorbic acid is 0.5-0.6:0.3-0.4:0.1, take 1-3g of acetic acid + citric acid + ascorbic acid solution and dilute to a mass fraction of 1-3% acetic acid + citric acid + ascorbic acid solution, denoted as A; 5g sodium polyphosphate dissolved in 100ml deionized water, adjust the pH value to 4-6, polyphosphate sodium solution; take 5g sodium hydroxide solution Prepare a 5% sodium hydroxide solution in 100ml deionized water for later use; (2) Add chitosan with a deacetylation degree > 80% to the acetic acid ...

Embodiment 3

[0048] A preparation method using chitosan as a carrier poultry medicine, comprising the following steps: the first step: preparation of high-strength chitosan microspheres; second step: preparation of chitosan microporous drug-loaded microspheres,

[0049] The first step: the preparation process of high-strength chitosan microspheres is as follows:

[0050] (1) Prepare acetic acid + citric acid + ascorbic acid solution, wherein the volume ratio of acetic acid, citric acid, and ascorbic acid is 0.6:0.4:0.1, measure 3g of acetic acid + citric acid + ascorbic acid solution and dilute to a mass fraction of 3% acetic acid + lemon Acid + ascorbic acid solution, denoted as A; 5g sodium polyphosphate was dissolved in 100ml of deionized water, adjusted to PH4~6, and the mass fraction was 5% sodium polyphosphate solution; 5g of sodium hydroxide was dissolved in 100ml of deionized water The obtained mass fraction is 5% sodium hydroxide solution for later use; (2) Add chitosan with a dea...

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Abstract

The invention relates to the field of biological medicine, in particular to a preparation method of poultry medicine taking chitosan as a carrier, and application. The poultry medicine comprises the raw materials in parts by weight as follows: 2-4 parts of purslane extract powder, 3-5 parts of semen ziziphi spinosae extract powder, 3-5 parts of astragalus polysaccharide, and 2-4 parts of vitamin C. The poultry medicine prepared according to the preparation method provided by the invention and taking chitosan as the carrier has the advantage: aiming at the current situation that a large amount of drug-resistant strains appear and a large amount of antibiotics and chemical antibacterial drugs lose efficacy because of bird flu, escherichia coli infection and other disease pathogen mixed infections and abuse of antibacterial drugs in poultry cultivation, the poultry medicine can realize one-step administration and cure and prevent two or more poultry diseases at the same time.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a method and application for preparing poultry medicine with chitosan as a carrier. Background technique [0002] Poultry farming has a history of more than 5,000 years in China. Since the reform and opening up for more than 30 years, the poultry breeding industry, which is a pillar industry of my country's animal husbandry, has developed rapidly, and has made certain progress in models and technologies. The poultry breeding industry must take the road of scale, intensification and industrialization. At this stage, my country's poultry farming is still dominated by small-scale and large groups, while large-scale and modern farming is on the rise. [0003] In my country's agricultural production, poultry breeding has always occupied an indispensable part, and poultry meat products have gradually become the dominant products for my country's export earnings. Existing problems exist in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K9/16A61K9/50A61K47/36A61P31/14A61P31/04A61K31/715A61K31/375
CPCA61K36/725A61K9/1652A61K9/5036A61K31/375A61K31/715A61K36/185A61K2236/333A61K2300/00
Inventor 张玉晗孙福道庄学昌林丽
Owner 山东锐基生物科技有限公司
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