Poultry medicine taking chitosan as carrier and preparation method of poultry medicine
A technology of chitosan and poultry medicine, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of increasing the difficulty and cost of clinical medication, the failure of antibiotics and chemical antibacterial drugs, The benefits of farmers cannot be guaranteed, etc., to achieve the effect of increasing drug loading rate, high product quality, and short production cycle
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Embodiment 1
[0036] A preparation method using chitosan as a carrier poultry medicine, comprising the following steps: the first step: preparation of high-strength chitosan microspheres; second step: preparation of chitosan microporous drug-loaded microspheres,
[0037] The first step: the preparation process of high-strength chitosan microspheres is as follows:
[0038] (1) Prepare acetic acid + citric acid + ascorbic acid solution, wherein the volume ratio of acetic acid, citric acid, and ascorbic acid is 0.5:0.3:0.1, take 1g of acetic acid + citric acid + ascorbic acid solution and dilute it to a mass fraction of 1% acetic acid + lemon Acid + ascorbic acid solution, denoted as A; 5g of sodium polyphosphate was dissolved in 100ml of deionized water, and the pH value was adjusted to 4-6 to obtain a 5% sodium polyphosphate solution; 5g of sodium hydroxide was dissolved in 100ml The sodium hydroxide solution with a mass fraction of 5% in deionized water is used for later use; (2) Chitosan w...
Embodiment 2
[0042] A preparation method using chitosan as a carrier poultry medicine, comprising the following steps: the first step: preparation of high-strength chitosan microspheres; second step: preparation of chitosan microporous drug-loaded microspheres,
[0043] The first step: the preparation process of high-strength chitosan microspheres is as follows:
[0044] (1) Prepare acetic acid + citric acid + ascorbic acid solution, wherein the volume ratio of acetic acid, citric acid, and ascorbic acid is 0.5-0.6:0.3-0.4:0.1, take 1-3g of acetic acid + citric acid + ascorbic acid solution and dilute to a mass fraction of 1-3% acetic acid + citric acid + ascorbic acid solution, denoted as A; 5g sodium polyphosphate dissolved in 100ml deionized water, adjust the pH value to 4-6, polyphosphate sodium solution; take 5g sodium hydroxide solution Prepare a 5% sodium hydroxide solution in 100ml deionized water for later use; (2) Add chitosan with a deacetylation degree > 80% to the acetic acid ...
Embodiment 3
[0048] A preparation method using chitosan as a carrier poultry medicine, comprising the following steps: the first step: preparation of high-strength chitosan microspheres; second step: preparation of chitosan microporous drug-loaded microspheres,
[0049] The first step: the preparation process of high-strength chitosan microspheres is as follows:
[0050] (1) Prepare acetic acid + citric acid + ascorbic acid solution, wherein the volume ratio of acetic acid, citric acid, and ascorbic acid is 0.6:0.4:0.1, measure 3g of acetic acid + citric acid + ascorbic acid solution and dilute to a mass fraction of 3% acetic acid + lemon Acid + ascorbic acid solution, denoted as A; 5g sodium polyphosphate was dissolved in 100ml of deionized water, adjusted to PH4~6, and the mass fraction was 5% sodium polyphosphate solution; 5g of sodium hydroxide was dissolved in 100ml of deionized water The obtained mass fraction is 5% sodium hydroxide solution for later use; (2) Add chitosan with a dea...
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