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Preparation method of novel adjuvant for haemophilus parasuis disease inactivated vaccines

A technology for haemophilus suis disease and inactivated vaccines, which is applied in the field of preparation of new adjuvants for haemophilus parasuis inactivated vaccines, can solve the problems of increasing difficulty and the influence of propolis adjuvant application and promotion, and achieve the improvement of antibody titer Effect

Pending Publication Date: 2016-08-10
LONGYAN UNIV
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Problems solved by technology

This increases the difficulty for further research on its mechanism of action, and also affects the application and promotion of propolis adjuvant

Method used

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  • Preparation method of novel adjuvant for haemophilus parasuis disease inactivated vaccines
  • Preparation method of novel adjuvant for haemophilus parasuis disease inactivated vaccines
  • Preparation method of novel adjuvant for haemophilus parasuis disease inactivated vaccines

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preparation example Construction

[0020] The preparation method of the new adjuvant of Haemophilus parasuis inactivated vaccine of the present invention comprises the following steps:

[0021] (1) Separating and extracting bacterial strains and preparing bacterial fluid antigens;

[0022] (2) Prepare vaccine stock solution;

[0023] (3) Preparation of finished vaccine products: Ginkgo biloba extract was selected as an adjuvant to prepare ginkgo biloba polyvalent inactivated vaccines with different concentrations of ingredients.

[0024] In the immunization dose of 2 mL / head, the amount of adjuvant is 2.5 mL-12.5 mL.

[0025] Ginkgo biloba extract stock solution contains 40 mg of extract per ml, which contains 9.6 mg of ginkgo flavonoid glycosides and 2.4 mg of terpene lactones (gingkolide, bilobalide).

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Abstract

The invention relates to a preparation method for a novel adjuvant for haemophilus parasuis disease inactivated vaccines .The method comprises the following steps of 1, separating and extracting bacterial strains and preparing bacteria solution antigen; 2, preparing a vaccine stock solution; 3, preparing finished vaccines, wherein a ginkgo biloba extract is selected as an adjuvant, and ginkgo biloba polyvalent inactivity vaccines of different concentrations, components and contents are prepared and obtained .The effective components of polysaccharose substances of the adjuvant are prepared through separation and extraction of traditional Chinese herbal medicine ginkgo biloba plants and then combined with haemophilus parasuis polyvalent inactivity vaccines, and the haemophilus parasuis ginkgo biloba adjuvant inactivated vaccines are prepared .The inactivated vaccines have the good immune modulating function, can regulate lymphocyte and phagocyte activity, can regulate the cell factor level in body serum, and have the advantages of being natural, low in toxicity, free of drug residues and the like .

Description

technical field [0001] The invention relates to a preparation method of a new adjuvant for Haemophilus parasuis inactivated vaccine, belonging to the technical field of pharmaceutical products. Background technique [0002] Traditional vaccines mostly use aluminum gel, mineral oil, and propolis as vaccine adjuvants, and aluminum salts are not a good adjuvant in many cases, especially in inducing cellular immune responses. Granulomas are commonly produced when aluminum adjuvants are injected subcutaneously or intradermally rather than intramuscularly. Another side effect is increased IgE production, allergic reactions and possible neurotoxicity. Mineral oil adjuvants can produce a series of side effects due to the disadvantage of being unable to be metabolized: including inflammatory reactions at the injection site, granulomas, ulcers, and fever. In addition, mineral oil and its components such as pristane and n-hexadecane can cause autoimmune reactions such as adjuvant art...

Claims

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Application Information

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IPC IPC(8): A61K39/39A61K39/102A61P31/04
CPCA61K39/102A61K39/39A61K2039/521A61K2039/552A61K2039/55588
Inventor 李晓华杨小燕邱龙新郑新添陈进境
Owner LONGYAN UNIV
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