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Novel use of the FoxO1 selective inhibitor AS1842856

A technology for wound healing, barriers, applied in the field of FoxO1 selective inhibitor AS1842856

Active Publication Date: 2019-02-05
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there is no report about AS1842856 in promoting wound healing in diabetic patients

Method used

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  • Novel use of the FoxO1 selective inhibitor AS1842856
  • Novel use of the FoxO1 selective inhibitor AS1842856
  • Novel use of the FoxO1 selective inhibitor AS1842856

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Example 1. FoxO1 selective inhibitor AS1842856 significantly promotes wound healing in diabetic mice

[0024] Male C57BL / 6 mice, 10-12 weeks old, were purchased from the Department of Experimental Animal Science, Peking University Health Science Center. Breeding conditions: 10 birds / cage, room temperature 22±1°C, humidity 50±10%°C, natural light, free access to food and water. All animals were acclimatized in the feeding environment for 5 days before the experiment, with free access to water.

[0025]Divide 40 above-mentioned male mice into 4 groups, 10 in each group: The specific grouping method is: one group for the control group, one group for the diabetes model group, and one group for the FoxO1 selective inhibitor AS1842856 group, respectively set high and low levels according to the dosage. Each dose was divided into two groups, two groups in total; the mice in the control group were intraperitoneally injected with sodium citrate buffer, and the mice in the diabe...

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Abstract

The invention discloses novel application of a FoxO1 selective inhibitor AS1842856. The novel application of a compound shown in a formula I is the application in the preparation of medicaments for the prevention and / or treatment of wound healing disorder, especially in the preparation of medicaments for diabetic wound healing disorders. Pharmacodynamics experiments confirm that AS1842856 can significantly promote wound healing of diabetic mice. The invention has good application prospect in the treatment of diabetic wound healing disorder.

Description

technical field [0001] The present invention relates to a new application of FoxO1 selective inhibitor AS1842856. Background technique [0002] Diabetes is a metabolic disease that seriously threatens human health. Wound healing disorder in diabetic patients is a common complication of diabetes. Severe cases can even lead to amputation. It is reported that there is one case of amputation caused by diabetes every 30 seconds in the world (Boulton, AJ, Vileikyte, L, Ragnarson-Tennvall, G, Apelqvist, J, 2005. The global burden of diabetic foot disease. Lancet. 366:1719-1724). Effective management and treatment of diabetic poor wound healing can significantly reduce the risk of amputation. At present, the commonly used treatment methods include debridement, use of dressings and topical drug administration. In recent years, many adjuvant treatment methods have emerged, such as negative pressure therapy, electrical stimulation, mechanical assisted treatment, etc. Among them, drug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/47A23L33/10A61P17/02A61P3/10
Inventor 铁璐李学军史运迪王卓飞陈锦文
Owner PEKING UNIV
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