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Method for measuring content of elemental iodine complexed in povidone-iodine

A technology of povidone iodine and its determination method, which is applied in the field of determination of the content of elemental iodine complexed in povidone iodine, can solve the problem of the inability to determine the content of complexed iodine, the inability to determine the slow-release property, iodine and polyethylene There is no way to judge the quality of pyrrolidone complexation, etc.

Inactive Publication Date: 2016-08-17
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing problem of povidone-iodine available iodine content determination is that the determination is elemental iodine in the product, including complexed iodine and uncomplexed elemental iodine, that is to say, it is impossible to determine the content of complexed iodine, i.e. iodine and polyiodine There is no way to judge whether the complexation of vinylpyrrolidone is good or not, but the slow release of iodine in povidone iodine after complexation with polyvinylpyrrolidone is the main reason why it is superior to elemental iodine
The existing determination method of iodine content in povidone-iodine has no way to determine the content of complexed iodine, and there is no way to determine its slow-release property

Method used

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  • Method for measuring content of elemental iodine complexed in povidone-iodine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 4.00g of pharmaceutical grade polyvinylpyrrolidone K30 and 1.00g of iodine into a three-necked flask equipped with a stirrer and a reflux condenser, add 10.0mL of ethanol to dissolve, heat the oil bath to 70°C, stir and reflux for 2 hours to prepare PVP-I. The prepared PVP-I sample was transferred to a 100mL volumetric flask and made to volume with distilled water. Then use a pipette to pipette 5.00 mL of the above constant-volume PVP-I solution, put it in a one-necked flask, add 25.00 mL of cyclohexane solution, and stir it electrically for 1 h. After the stirring was stopped, the mixture in the one-necked flask was transferred to a separatory funnel. After standing to separate layers, the cyclohexane layer and the PVP-I solution layer were placed in conical flasks respectively. Use the calibrated 0.1mol / L Na 2 S 2 o 3 The standard solution was titrated for two samples. The analysis result is that the upper cyclohexane solution contains 12.44 mg of iodine, an...

Embodiment 2

[0023] Add 4.00g of pharmaceutical grade polyvinylpyrrolidone K30 and 1.00g of iodine into a three-necked flask equipped with a stirrer and reflux condenser, add 10.0mL of ethanol to dissolve, heat the oil bath to 70°C, stir and reflux for 4 hours to prepare PVP-I. The prepared PVP-I sample was transferred to a 100mL volumetric flask and made to volume with distilled water. Then use a pipette to pipette 5.00 mL of the above constant-volume PVP-I solution, put it in a one-necked flask, add 25.00 mL of cyclohexane solution, and stir it electrically for 1 h. After the stirring was stopped, the mixture in the one-necked flask was transferred to a separatory funnel. After standing to separate layers, the cyclohexane layer and the PVP-I solution layer were placed in conical flasks respectively. Use the calibrated 0.1mol / L Na 2 S 2 o 3 The standard solution was titrated for two samples. The result of the analysis is that the upper cyclohexane solution contains 9.90 mg of iodine...

Embodiment 3

[0025] Add 6.00g of pharmaceutical grade polyvinylpyrrolidone K30 and 1.00g of iodine into a three-necked flask equipped with a stirrer and reflux condenser, add 10.0mL of ethanol to dissolve, heat the oil bath to 60°C, stir and reflux for 6 hours to prepare PVP-I. The prepared PVP-I sample was transferred to a 100mL volumetric flask and made to volume with distilled water. Then use a pipette to pipette 5.00 mL of the above constant-volume PVP-I solution, put it in a one-necked flask, add 25.00 mL of cyclohexane solution, and stir it electrically for 1 h. After the stirring was stopped, the mixture in the one-necked flask was transferred to a separatory funnel. After standing to separate layers, the cyclohexane layer and the PVP-I solution layer were placed in conical flasks respectively. Use the calibrated 0.1mol / L Na 2 S 2 o 3 The standard solution was titrated for two samples. The result of analysis is that the upper cyclohexane solution contains 7.61 mg of iodine, an...

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Abstract

The invention relates to a method for measuring the content of elemental iodine complexed in povidone-iodine, and particularly provides a method for measuring the content of elemental iodine complexed in povidone-iodine. According to the method, complexed iodine and non-complexed iodine in povidone-iodine are separated by using an organic solvent firstly, and then the content of complexed iodine in povidone-iodine is measured. According to the technical scheme of the invention, the content of complexed iodine in a povidone-iodine product can be really and effectively measured.

Description

technical field [0001] The invention relates to a method for determining the content of complexed elemental iodine in povidone iodine, specifically a method for separating complexed iodine in povidone iodine from uncomplexed iodine by using an organic solvent, and then measuring Method for complexing iodine content in povidone-iodine. Background technique [0002] Povidone-iodine is a complex iodine formed by polyvinylpyrrolidone (PVP) and iodine in a complex form with the help of hydrogen bonds. The molecular formula is (C 6 h 9 I 2 NO) n , its structural formula is as follows: [0003] [0004] Povidone-iodine, also known as polyvinylpyrrolidone-iodine, iodophor, and Yisujing, can be expressed as PVP-I. It is an internationally recognized high-efficiency, broad-spectrum, and non-toxic fungicide. It has a strong killing effect on Staphylococcus aureus, hepatitis B virus, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Escherichia coli, virus Mycobacterium tuberculosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/34
CPCG01N1/34
Inventor 林富荣顾金艳
Owner CHANGZHOU UNIV
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