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Preparation method for hydroxyethyl cellulose hemostatic gauze

A technology of hydroxyethyl cellulose and hemostatic gauze, which is applied in ultrasonic/sonic fiber processing, non-woven fabrics, medical science, etc., can solve problems such as increasing surgical risks, endangering life and health, and affecting surgical quality, so as to reduce blood flow Speed, increase water absorption rate, increase the effect of water absorption ratio

Inactive Publication Date: 2016-08-24
CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Bleeding or oozing is one of the problems that need to be solved urgently in surgery. Wound bleeding or oozing during surgery often leads to unclear surgical field of vision, prolongs the operation time, affects the quality of surgery, increases the risk of surgery, and serious complications occur , such as hemorrhagic shock, can even endanger life and health
Traditional methods of hemostasis, such as compression, ligation, etc., are not very satisfactory in terms of clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh a certain amount of hydroxyethyl cellulose and dissolve it in distilled water, stir evenly, and prepare a hydroxyethyl cellulose solution with a concentration of 1wt%, then place the solution in an ultrasonic treatment device for ultrasonic treatment, and the ultrasonic frequency is 30kHz, ultrasonic power 300W, ultrasonic treatment time 25min, after ultrasonic treatment, wash with 85% ethanol solution, and dry at constant temperature to obtain hydroxyethyl cellulose powder.

[0016] Weigh a certain amount of hydroxyethyl cellulose powder obtained by ultrasonic treatment and dissolve it in distilled water, stir evenly, and prepare a hydroxyethyl cellulose solution with a concentration of 5wt%, which is the spinning solution, and then the spinning solution Placed in an electrospinning device for spinning, the spinning process parameters are set as follows: the inner diameter of the spinning nozzle is 0.4mm, the flow rate of the spinning nozzle is 1.0ml / h, the static...

Embodiment 2

[0018] Weigh a certain amount of hydroxyethyl cellulose and dissolve it in distilled water, stir evenly, and prepare a hydroxyethyl cellulose solution with a concentration of 2wt%, then place the solution in an ultrasonic treatment device for ultrasonic treatment, and the ultrasonic frequency is 35kHz, ultrasonic power 350W, ultrasonic treatment time 20min, after ultrasonic treatment, wash with 85% ethanol solution, and dry at constant temperature to obtain hydroxyethyl cellulose powder.

[0019] Weigh a certain amount of hydroxyethyl cellulose powder obtained by ultrasonic treatment and dissolve it in distilled water, stir evenly, and prepare a hydroxyethyl cellulose solution with a concentration of 5wt%, which is the spinning solution, and then the spinning solution Placed in an electrospinning device for spinning, the spinning process parameters are set as follows: the inner diameter of the spinning nozzle is 0.4mm, the flow rate of the spinning nozzle is 1.0ml / h, the static...

Embodiment 3

[0021] Weigh a certain amount of hydroxyethyl cellulose and dissolve it in distilled water, stir evenly, and prepare a hydroxyethyl cellulose solution with a concentration of 2wt%, then place the solution in an ultrasonic treatment device for ultrasonic treatment, and the ultrasonic frequency is 35kHz, ultrasonic power 350W, ultrasonic treatment time 20min, after ultrasonic treatment, wash with 85% ethanol solution, and dry at constant temperature to obtain hydroxyethyl cellulose powder.

[0022] Weigh a certain amount of hydroxyethyl cellulose powder obtained by ultrasonic technology and dissolve it in distilled water, stir evenly, and prepare a hydroxyethyl cellulose solution with a concentration of 10wt%, which is the spinning solution, and then the spinning solution Placed in an electrospinning device for spinning, the spinning process parameters are set as follows: the inner diameter of the spinning nozzle is 0.6mm, the flow rate of the spinning nozzle is 0.5ml / h, the stat...

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PUM

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to a preparation method for hydroxyethyl cellulose hemostatic gauze. The hydroxyethyl cellulose hemostatic gauze is prepared by taking hydroxyethyl cellulose as a raw material and combining an ultrasonic processing technique with an electrospinning technique; a series of drying and sterilizing are performed, so that the hydroxyethyl cellulose hemostatic gauze is prepared. Hydroxy propyl cellulose belongs to neutral etherification products, overcomes a defect that the polar group is easy to generate a stimulation reaction to an organic body, and has the characteristics of high water swelling performance and quick hemostatic performance. The hydroxyethyl cellulose hemostatic gauze is nontoxic without stimulation, the process is simple and feasible, and the clinic application prospect is wide.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of hydroxyethyl fiber hemostatic gauze. Background technique [0002] Bleeding or oozing is one of the problems that need to be solved urgently in surgery. Wound bleeding or oozing during surgery often leads to unclear surgical field of vision, prolongs the operation time, affects the quality of surgery, increases the risk of surgery, and serious complications occur , such as hemorrhagic shock, can even endanger life and health. Traditional hemostasis methods such as compression, ligation, etc., are not very satisfactory in terms of clinical application. At present, the commonly used effective hemostasis method is to use biocompatible absorbable materials to stop bleeding. It is particularly important to provide a safe, effective, easy-to-use, and low-cost hemostatic material in hemostasis such as surgery and first aid. [0003] Ultrasound ca...

Claims

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Application Information

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IPC IPC(8): D04H1/728D04H1/4258D06M10/02A61L15/28A61L15/42
Inventor 张大刘琼林玲
Owner CHONGQING LIANBAI BOCHAO MEDICAL EQUIP
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