High-density hollow micro-needle array based on negative photoresist and manufacturing technology thereof

Abstract

The invention discloses a high-density hollow micro-needle array based on negative photoresist and a manufacturing technology thereof, and belongs to the technical fields of medical cosmetic instruments and micro-needles for medical administration. The micro-needle array can be applied to painless, safe and efficient transdermal delivery. The micro-needle array is formed by combining a large quantity of single micro-needles, and the density can reach 8000 to 10000 single micro-needles per square centimeter. Each single micro-needle comprises a hollow channel for liquid to pass, at least one needle body arranged on the side surface of the hollow channel and used for enabling liquid to flow out, and a solid syringe needle positioned at the top end of the hollow channel. The invention discloses a tensile photoetching setting technology through the sensitive property and the viscidity of the negative photoresist, that is, the syringe needle is manufactured at the top end of the needle body in a tensile manner after the manufacture of the needle body. Compared with the prior art, the micro-needle array and the manufacturing technology thereof have the advantages of high density, low cost and high easiness in large-scale production.

Description

technical field [0001] The invention relates to the technical field of microneedles for medical cosmetic devices and medicine administration, in particular to a high-density hollow microneedle array based on negative photoresist and its manufacturing process. Background technique [0002] In the current clinical treatment, the delivery of therapeutic drugs mainly adopts the means of needle injection. Although needle injection has many advantages, such as fast and effective, low cost and applicable to various types of drugs, there are also many problems: needle injection will inevitably bring about pain reactions, and often patients, especially children, will The fear reaction to this pain leads to the inconvenience of injection; at the same time, the needle injection may cause skin and muscle damage or skin infection, and there is also the possibility of cross-infection. According to the statistics of the World Health Organization, more than one Millions of people die from ...

AI Technical Summary

Problems solved by technology

Although needle injection has many advantages, such as fast and effective, low cost and applicable to various types of drugs, there are also many problems: needle injection will inevitably bring about pain reactions, and often patients, especially children, will The fear reaction to this pain leads to the inconvenience of injection; at the same time, the needle injection may cause skin and muscle damage or skin infection, and there is also the possibility of cross-infection. According to the statistics of the World Health Organization, more than one Millions of people die from cross-infection of needles; in addition, the bio-waste brought by disposable syringes will cause environmental pollution and waste of resources; finally, needle injections generally require trained professionals such as nurses to operate, which limits the use of needle injections. convenience of medicine

Microneedles prepared by injection molding generally have disadvantages such as large gaps between microneedles and thick microneedles. It is difficult to make high-density microneedle arrays, which limits the efficiency of microneedle drug delivery.

The microneedle array prepared by injection molding can generally only reach 400-800 pieces per square centimeter, which has no great advantage over traditional transdermal drug delivery.

Although the microneedle array manufactured by photolithography using materials such as monocrystalline silicon can achieve a higher density, its manufacturing cost is very high, which greatly limits the wide application of microneedle drug delivery.

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