ror1 specific chimeric antigen receptor and its application

A chimeric antigen receptor, specific technology, applied in application, antibody mimics/scaffolds, for targeting specific cell fusion, etc., can solve the problems of T cells killing normal B cells and releasing a large number of cytokines and other side effects
CN105924533BActive Publication Date: 2020-04-21BEIJING BIOHEALTHCARE BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING BIOHEALTHCARE BIOTECH
Publication Date
2020-04-21

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Abstract

The invention discloses an ROR1 specific chimeric antigen receptor and an application thereof. The ROR1 specific chimeric antigen receptor is a protein formed through serially connecting scFv of anti-human ROR1, the hinge region and the transmembrane region of CD8alpha, the transmembrane region and the intracellular region of CD28 and the intracellular region of CD3zeta from the amino end to the carboxyl end. T cells modified with the chimeric antigen receptor have a specific killing effect on tumor cells, and are expected to be in widely used in treatment of all kinds of solid tumor and blood tumors.
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Description

technical field

[0001] The invention belongs to the technical field of biology and medicine, and relates to a ROR1-specific chimeric antigen receptor and its application. Background technique

[0002] With the development of tumor immunology theory and technology, adoptive cell immunotherapy has made great progress in recent years, and the achievement of tumor-targeted immunotherapy represented by chimeric antigen receptor (chimeric antigen receptor, CAR) modified T cells is particularly important. Outstanding, in vitro and clinical trials showed good targeting, lethality and persistence, showing great application potential and development prospects. Even so, there are not many tumor-specific target antigens to choose from, the killing effect is not significant, and there are safety issues such as "cytokine storm" and "off-target effects". Therefore, a new generation of broad-spectrum, efficient and safe tumor Targeted immunotherapy is the future development trend of cellul...

Claims

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