Chromatographic column used for liquid chromatography
A liquid chromatography and chromatographic column technology, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of reducing the efficiency of chromatographic columns, and achieve the effects of good corrosion resistance, improved efficiency, and high friction and wear strength
Inactive Publication Date: 2016-09-07
YANTAI UNIV
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Problems solved by technology
In the chromatographic column of the prior art, after the mobile phase enters the chromatographic column, under the influence of radial inhomogeneity, its flow velocity presents a distribution state of fast in the middle and slow around the four sides, and this distribution is continuously accumulated with the increase of the migration distance Yes, the column with this structure will seriously reduce the efficiency of the column
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[0017] figure 1 It is a structural schematic diagram of the chromatographic column used for liquid chromatography detection in the present invention. Such as figure 1 As shown, the chromatographic column used for liquid chromatography detection of the present invention includes a column body 5, and caps 3 installed at both ends of the column body 5, wherein the cap at one end is provided with an inlet 1, and the cap at the other end is An outlet 2 is provided on the head, and a sieve plate 4 installed between the cylinder 5 and the head 3 is also included. Such as figure 2 As shown, the sieve plate 4 includes a plate body 43, a concentric solid body 42 located at the center of the plate body 43, and several through holes 41 with the same shape and equally spaced distribution on the plate body 43; The diameter of the solid body is larger than the inner diameter of the inlet, and the diameter of the solid body is larger than the inner diameter of the outlet; a gap 6 is provi...
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The invention relates to a chromatographic column used for liquid chromatography. The chromatographic column comprises a column body, sealing heads arranged at two ends of the column body, and sieve plates arranged between the column body and the sealing heads, wherein the sealing head at one end of the column body is provided with an inlet, the sealing head at the other end of the column body is provided with an outlet, and every sieve plate comprises a plate body, a concentric circular solid body positioned in the center of the plate body, and a plurality of equidistantly distributed through holes with the same shape; the diameter of every solid body is greater than the internal diameter of the inlet, and the diameter of every solid body is greater than the internal diameter of the outlet; and a slit is arranged between every sealing head and the corresponding sieve plate. The column body is formed by a three layer structure comprising a ceramic inner layer, a graphene fiber middle layer and a ceramic fiber outer layer from inside to outside. The chromatographic column with the sieve plate structure has improved efficiency, and can be widely applied.
Description
technical field [0001] The invention relates to a chromatographic column for liquid chromatography detection. Background technique [0002] In the field of drug research and development, any component in the drug whose chemical structure is different from the drug is called an impurity, and the impurities that are similar in structure to the drug or have origins are also called related substances. Their existence has seriously affected people. Medication safety and good health. As a result, the systematic study of impurities in drugs, especially related substances, and strict control of their content have become more and more widely valued by researchers. The structure, source, and change trend are all uncertain, which brings great challenges to the work of researchers. [0003] Among them, the application of chromatographic technology in drug analysis is becoming more and more important, and chromatographic columns play a decisive role in chromatographic analysis. In the...
Claims
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CPCG01N30/606
Inventor 许丽晓耿银银刘万卉
Owner YANTAI UNIV