Synthesis method of vitamin A palmitate

Abstract

The invention discloses a synthesis method of vitamin A palmitate. The method is characterized in that vitamin A palmitate is prepared by vitamin A acetate and palmitic acid through an enzyme method reaction. The method comprises the following steps: vitamin A acetate and palmitic acid are dissolved in an organic solvent to prepare a reaction material, the reaction material is pre-heated and is sent to a reaction column for consecutive reaction according to a certain flow; the reaction column is filled with immobilization lipase and ion exchange resin, the reaction material is proportional lipase and ion exchange resin; and after the reaction is completed, a reaction solution is post-treated to obtain the vitamin A palmitate. The vitamin A palmitate has the advantages of high yield and good quality. The appearance of the vitamin A palmitate is a light yellow grease substrate. By analyzing with United States Pharmacopeia USP28, the content is greater than 95%.

Description

technical field

[0001] The invention relates to a vitamin A, in particular to a synthesis method of vitamin A palmitate. Background technique

[0002] Vitamin A palmitate is a known compound whose structural formula is:

[0003]

[0004] Vitamin A palmitate has been widely used as medicine, food additive and feed additive, etc., and there have been many reports about its synthesis. These methods include the method of preparing vitamin A palmitate from vitamin A alcohol or vitamin A lower fatty acid esters as raw materials. The method involves a variety of reaction routes, wherein the synthetic route disclosed in Japanese Patent JP62248495 is: vitamin A acetate and palmitate Acid is obtained vitamin A palmitate under the action of lipase. The synthetic route disclosed in British Patent GB816224 is: vitamin A alcohol and palmitic acid alkyl ester are obtained vitamin A palmitate under the action of sodium methylate. The disclosed synthetic route of British Patent GB12930...

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