Synthesis method of vitamin A palmitate

A technology of palmitate and synthesis method, applied in directions such as fermentation, can solve problems such as low yield and high instability of vitamin A alcohol, and achieve the effect of avoiding influence and reducing the difficulty of separation and purification

Active Publication Date: 2016-09-28
XIAMEN KINGDOMWAY VI TAMIN INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, vitamin A alcohol is highly unstable and is easily destroyed under the influence o

Method used

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  • Synthesis method of vitamin A palmitate
  • Synthesis method of vitamin A palmitate
  • Synthesis method of vitamin A palmitate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Cooperate figure 1 As shown, vitamin A acetate (20g) and palmitic acid (52g) are dissolved in n-hexane (480g), put into the raw material tank 1, set the flow rate at 10ml / min, and deliver the above solution to the pre- In the heater 3, it is preheated to 40°C through the preheater 3, and then sent to the reaction column 4 for reaction, and the reaction process controls the reaction temperature to remain at 40°C; the reaction column is filled with Novozyne435 (120g) and Amberlyst A21 (60g), Mix both well. The reaction solution was cooled to crystallization, and the filtrate was concentrated to obtain a light yellow oil, which was then sent to the product tank 5. The resulting oil was analyzed according to the method of United States Pharmacopoeia USP28. The results showed that the content of vitamin A palmitate was 95.63%. The conversion rate was 96.93%.

Embodiment 2

[0039] Same fit figure 1 As shown, dissolve vitamin A acetate (1g) and palmitic acid (2.6g) in n-hexane (24g), add Novozyne435 (0.25g) and Amberlyst A21 (0.5g), place in a shaker, adjust the speed at 250rpm, The reaction temperature was maintained at 40°C; the reaction was 6h. The reaction solution was filtered and cooled to crystallization, and the filtrate was concentrated to obtain a pale yellow oil. The resulting oil was analyzed according to the method of United States Pharmacopoeia USP28. The results showed that the content of vitamin A palmitate was 88.63%. The conversion rate was 90.93%.

Embodiment 3

[0041] With embodiment 1, palmitic acid quality is changed into 56g. The resulting oil was analyzed according to the method of United States Pharmacopoeia USP28. The results showed that the content of vitamin A palmitate was 97.71%. The conversion rate is 97.95%.

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Abstract

The invention discloses a synthesis method of vitamin A palmitate. The method is characterized in that vitamin A palmitate is prepared by vitamin A acetate and palmitic acid through an enzyme method reaction. The method comprises the following steps: vitamin A acetate and palmitic acid are dissolved in an organic solvent to prepare a reaction material, the reaction material is pre-heated and is sent to a reaction column for consecutive reaction according to a certain flow; the reaction column is filled with immobilization lipase and ion exchange resin, the reaction material is proportional lipase and ion exchange resin; and after the reaction is completed, a reaction solution is post-treated to obtain the vitamin A palmitate. The vitamin A palmitate has the advantages of high yield and good quality. The appearance of the vitamin A palmitate is a light yellow grease substrate. By analyzing with United States Pharmacopeia USP28, the content is greater than 95%.

Description

technical field [0001] The invention relates to a vitamin A, in particular to a synthesis method of vitamin A palmitate. Background technique [0002] Vitamin A palmitate is a known compound whose structural formula is: [0003] [0004] Vitamin A palmitate has been widely used as medicine, food additive and feed additive, etc., and there have been many reports about its synthesis. These methods include the method of preparing vitamin A palmitate from vitamin A alcohol or vitamin A lower fatty acid esters as raw materials. The method involves a variety of reaction routes, wherein the synthetic route disclosed in Japanese Patent JP62248495 is: vitamin A acetate and palmitate Acid is obtained vitamin A palmitate under the action of lipase. The synthetic route disclosed in British Patent GB816224 is: vitamin A alcohol and palmitic acid alkyl ester are obtained vitamin A palmitate under the action of sodium methylate. The disclosed synthetic route of British Patent GB12930...

Claims

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Application Information

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IPC IPC(8): C12P23/00
CPCC12P23/00
Inventor 陈晓伟江朝钦潘必文黄聿魏范永生林文辉张水陆何剑洋
Owner XIAMEN KINGDOMWAY VI TAMIN INC
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