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81results about How to "Reduce the difficulty of separation and purification" patented technology
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High-purity silymarin and preparation method thereof
ActiveCN102174041ASmall impurity interferenceReduce the difficulty of separation and purificationOrganic chemistryKetoneChemistry
The invention discloses a high-purity silymarin and a preparation method thereof. The content of the high-purity silymarin is 97-101%. The preparation method of the high-purity silymarin comprises the following steps of: taking a silymarin shell as a raw material; adding ethyl acetate for dissolving the silymarin shell; extracting total flavones; collecting flavones in vacuum; and dissolving, extracting, filtering and drying the total flavones to obtain the high-purity silymarin. The invention has the advantages that on the basis of a silymarin seed, shell and kernel separating technology, the silymarin shell is used as the raw material for preparing the silymarin, the total flavones are extracted and then separated and purified by using ethanol with different concentration, and a recrystallization technology is adopted to prepare the high-purity silymarin. Because 99% of silymarin oil exists in the silymarin kernel, the silymarin shell is used for extracting the total flavones, the grease is little, a traditional method in which gasoline, petroleum ether and other organic solvents are used for degreasing is not required, and impurity interference, separation and purification difficulty and environment pollution are reduced. The preparation method disclosed by the invention is relatively simple, and the product quality and yield of the high-purity silymarin are greatly improved.
Owner:ZHONGXING PHARM CO LTD JIANGSU
Method of extracting squalene from bottom sediment with natural vitamin E extracted
ActiveCN105367370AReduce loadReduce difficulty and costDistillation purification/separationHydrocarbonsChemistrySqualene
The invention discloses a method of extracting squalene from bottom sediment with natural vitamin E extracted. The bottom sediment with the natural vitamin E extracted is used as the raw material to prepare high-content squalene through a saponification, rectification and silica gel column chromatography combined process. The method specifically comprises the steps that firstly, the bottom sediment is subjected to a saponification reaction, unsaponifiable matter obtained through extraction is subjected to separation in a secondary rectifying tower, distillate obtained through secondary rectification is used as the raw material and subjected to silica gel column chromatography separation, three organic solvents with different polarities are used for elution, and fractional collection is conducted to obtain a plant hydrocarbon component, a squalene component, a natural vitamin E component and a sterol component, wherein the squalene content of the squalene component is more than 95%. According to the method, the bottom sediment with the natural vitamin E extracted is used as the raw material for extraction of the squalene, the process is simple and convenient, separation efficiency is high, industrial production is easy, the obtained squalene content is high, crude natural vitamin E and sterol can also be obtained, and comprehensive utilization of effective ingredients in the bottom sediment is achieved.
Owner:ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
Separation and purification method for garnets of iron ore tailings and product of method
ActiveCN106000627AReduce the difficulty of separation and purificationLong-term retention of characteristicsSievingScreeningPurification methodsMagnetization
Owner:河源紫金天宏科技有限公司
Construction method and use of Streptomyces roseosporus gene engineering bacteria
ActiveCN102146414AIncrease productionReduce manufacturing costBacteriaMicroorganism based processesEscherichia coliRibosomal protein E-L30
The invention provides a construction method and use of Streptomyces roseosporus gene engineering bacteria. The construction method comprises: cloning upstream and downstream accessory key genes dptE, dptF, dptG, dptH, dptI and dptJ of a nonribosomal peptide synthetases (NRPS) gene in a daptomycin gene cluster; and constructing recombinant plasmids by using an Escherichia coli-Streptomyces shuttle expression vector. The recombinant plasmids are transferred into Escherichia coli ET12567 to culture the ET12567 and the Streptomyces roseosporus together, the Streptomyces roseosporus is transformed by a combined transfer method, a transformant is screened by brulamycin resistance and polymerase chain reaction (PCR) is performed for further confirmation. The Streptomyces roseosporus gene engineering bacteria constructed by the invention can be directly used in the industrial production of daptomycin and can improve yield and reduce cost.
Owner:NANTONG YIKAI MEDICAL DEVICES CO LTD
Method for preparing key intermediate of limaprost
InactiveCN102875586AReserved configurationMild reaction conditionsGroup 4/14 element organic compoundsStructural formulaLimaprost-alfadex
The invention discloses a method for preparing the key intermediate of limaprost, particularly provides a chiral compound of formula I and a preparation method thereof. The method comprises the following steps: (1) reacting a compound of formula 3 with a compound of formula 4 to obtain a compound of formula 5; (2) reacting a compound of formula 6 with the compound of formula 5 to obtain a compound of formula 7; (3) mixing the compound of formula 7 with a compound of formula 8 to obtain the compound of formula 1; (4) reacting the compound of formula 1 with a reducing agent to obtain a raw product, separating and purifying the raw product by column chromatography to obtain a compound of formula 2; (5) reacting the compound of formula 2 with a protector reduction agent to obtain a compound of formula 9, wherein each structural formula and substituent are defined as the specification. According to the invention, the method has mild reaction conditions, and the high-purity chiral compound can be conveniently and efficiently prepared.
Owner:SHANGHAI TECHWELL BIOPHARMACEUTICALS CO LTD
Synthesis method of vitamin A palmitate
ActiveCN105969833AAvoid influenceReduce the difficulty of separation and purificationFermentationEnzyme methodConsecutive reaction
The invention discloses a synthesis method of vitamin A palmitate. The method is characterized in that vitamin A palmitate is prepared by vitamin A acetate and palmitic acid through an enzyme method reaction. The method comprises the following steps: vitamin A acetate and palmitic acid are dissolved in an organic solvent to prepare a reaction material, the reaction material is pre-heated and is sent to a reaction column for consecutive reaction according to a certain flow; the reaction column is filled with immobilization lipase and ion exchange resin, the reaction material is proportional lipase and ion exchange resin; and after the reaction is completed, a reaction solution is post-treated to obtain the vitamin A palmitate. The vitamin A palmitate has the advantages of high yield and good quality. The appearance of the vitamin A palmitate is a light yellow grease substrate. By analyzing with United States Pharmacopeia USP28, the content is greater than 95%.
Owner:XIAMEN KINGDOMWAY VI TAMIN INC +1
Phosgenation reactor and method for preparing isocyanate monomer by using phosgenation reactor
ActiveCN108079921AShort stayReduce exposureIsocyanic acid derivatives preparationOrganic compound preparationIsocyanateHydrogen chloride
The invention discloses a phosgenation reactor and a method for preparing an isocyanate monomer by using the phosgenation reactor. The phosgenation reactor comprises an inner material inlet pipe, an outer material inlet pipe, a mechanical stirring rotation shaft, a rotation area and a kettle body, wherein the rotation area comprises a support structure, a rotation area filler block, an upper material outlet device and a lower material outlet device, the inner material inlet pipe and the outer material inlet pipe are coaxially arranged from inside to outside, the upper material outlet device and the lower material outlet device are arranged in parallel, are connected through the support structure, and are respectively communicated to the outer material inlet pipe and the inner material inlet pipe, the rotation area filler block is filled between the upper material outlet device and the lower material outlet device, the upper material outlet device is connected to the mechanical stirringrotation shaft, and the kettle body is provided with a gas phase material outlet, a liquid phase material outlet, a gas phase material inlet and a liquid phase material inlet. According to the present invention, by pre-treating the hydrochloride solution in the reactor, the salt forming concentration and the quality of the hydrochloride solution are improved while the rapid removal of hydrogen chloride gas during the phosgenation is achieved, such that the generation of chlorination by-products is effectively reduced, and the product separation difficulty is reduced.
Owner:WANHUA CHEM GRP
Method for extracting taxane active ingredients from Chinese yew efficiently
ActiveCN103408512AReduce usageReduce the difficulty of separation and purificationSugar derivativesSugar derivatives preparationTaxusChemistry
The invention discloses a method for extracting taxane type active ingredients from Chinese yew efficiently. The method comprises the following steps of: firstly extracting with water, further extracting with alcohol, and further purifying by a traditional purification method to get paclitaxel, 10-deacetyl baccatin III, taxol-7-xyloside, cephalomanine and other non-water-soluble taxane type substance monomers. According to the method disclosed by the invention, macroporous resin is applied to the extraction process, the extraction yield of the active ingredients is far higher than that of a traditional extraction method, the using quantity of an organic solvent is further significantly reduced, and the method is suitable for large-scale production of the paclitaxel and comprehensive extraction of other taxane active ingredient substances.
Owner:浙江大德龙生物技术有限公司
Method for improving concentration of methanol oxo-synthesized dimethyl carbonate crude product
InactiveCN104418749AIncrease concentrationReduce the difficulty of separation and purificationMolecular sieve catalystsOrganic compound preparationFluid phaseDimethyl carbonate
The invention relates to a method for improving concentration of a methanol oxo-synthesized dimethyl carbonate crude product, and the method comprises a first order synthetic reaction and a second order synthetic reaction; condensation and gas-liquid separation of a gas-liquid mixed material from an inlet of a first order dimethyl carbonate reactor of the first order synthetic reaction are performed; a separated liquid phase is pumped into a second order dimethyl carbonate reactor to participate into the second order synthetic reaction; and the separated CO-containing gas enters into the second order dimethyl carbonate reactor to participate into the second order synthetic reaction. The method adopts two order series of carbonyl oxidation process for co-production of dimethyl carbonate, through the adjustment of carbonyl oxidation synthesis process parameters, the concentration of the dimethyl carbonate crude product is increased to more than 30%, the difficulty of separation and purification of the dimethyl carbonate product is greatly reduced, and the production cost of the product is significantly reduced.
Owner:黄志忠
Energy-saving methane chloride production system and method
ActiveCN108409526AEffective recovery of heatTake advantage ofHalogenated hydrocarbon separation/purificationHeat flowGas phase
The invention discloses an energy-saving methane chloride production method. The method includes: liquid raw material methanol is heated in a methanol vaporizer, and the methanol is mixed with hydrogen chloride and then enters a reaction kettle through a gas-phase inlet in the lower portion of the reaction kettle; the kettle-bottom produced liquid of the reaction kettle is used as the heating medium of the methanol vaporizer, and the kettle-bottom produced liquid is subjected to heat exchanging through the methanol vaporizer and circulated to a liquid-phase inlet in the upper portion of the reaction kettle; liquid and gas are in continuous countercurrent contact on a tower plate or filler in the reaction kettle; high-temperature mixed gas in the reaction kettle escapes from the top of thereaction kettle, and the gas is cooled by a first condenser and a second condenser and then conveyed to a purification system. The invention further discloses an energy-saving production system used for achieving the method above. The method has the advantages that heat flow produced at the bottom of the reaction kettle and the raw material methanol are subjected to heat exchanging in the methanolvaporizer, the heat carried by the high-temperature heat flow is recycled effectively, reaction heat is utilized sufficiently, all steam needed by methanol preheating and vaporization is saved, and an evident energy saving effect is achieved.
Owner:SEDIN NINGBO ENG
Method for leaching valuable metal from cobalt-copper white alloy
ActiveCN105063353AGuaranteed not to be oxidizedAchieve separationProcess efficiency improvementSlagManganese
The invention discloses a method for leaching valuable metal from cobalt-copper white alloy. The method includes the following steps that (1) the cobalt-copper white alloy is melted into an alloy melt, wherein the cobalt-copper white alloy contains silicon and almost contains no manganese; (2) a Mn-containing material is added into the alloy melt, and meanwhile gas is led in for blowing and slagging; (3) obtained slag is separated from the melt; (4) the melt with the slag separated out is atomized into alloy powder, wherein the mass friction of Mn in the alloy powder is 0.5%-20%; and (5) the alloy powder is subjected to acid leaching, and the valuable metal is recovered. Due to the fact that the Mn-containing material is added and reacts with the silicon in the cobalt-copper white alloy to generate the MnO-SiO2 slag, the silicon removal effect is achieved, and the method has the beneficial effects of being good in silicon removal effect and small in valuable metal loss. Besides, the melting temperature is much lower than the melting point of CaO-(MgO)-SiO2 binary system or ternary system slag in the prior art.
Owner:CHANGSHA RES INST OF MINING & METALLURGY
Method for treating nickel/cobalt-contained multi-metal alloyed scrap
ActiveCN105018735AEfficient use ofIn line with development ideasProcess efficiency improvementSlagManganese
A method for treating nickel / cobalt-contained multi-metal alloyed scrap comprises the following steps that the multi-metal alloyed scrap is molten to form alloy melt; at least one kind of nickel metal and cobalt metal is included in the multi-metal alloyed scrap, and Mn and Si are hardly included in the multi-metal alloyed scrap; one or more kinds of tungsten, molybdenum and vanadium are further included in the multi-metal alloyed scrap; manganese-contained materials and silicon-contained materials are added, and meanwhile oxygen-contained gas is pumped in for blowing slagging; obtained formed slag is separated out of the alloy melt; the alloy melt obtained after the formed slag is separated out is atomized into alloy powder; at least 0.5% of Mn elements is included in the alloy powder; acid leaching is carried out on the obtained alloy powder; and the obtained formed slag is leached out through strong alkali, and valuable metal in the formed slag is recycled. The method has the beneficial effects that resources are fully utilized; the utilization rate of raw materials is high; the use efficiency of a furnace is high; cost is low; operation is easy; and energy saving and environmental protection are achieved.
Owner:CHANGSHA RES INST OF MINING & METALLURGY
Effective part of ginseng stems and leaves, as well as preparation method and application thereof
ActiveCN105640970ALow quality controllabilityImprove quality controllabilityOrganic active ingredientsMetabolism disorderDiabetes mellitusHas active ingredient
The invention relates to an effective part of ginseng stems and leaves, as well as a preparation method and an application thereof, belongs to the technical field of natural medicinal materials, and aims to provide an effective part of ginseng stems and leaves having simple composition for treating or preventing diabetes mellitus and related complications. The active ingredient of the effective part comprises ginsenoside Re and ginsenoside Rg1 in a mass ratio of 1:(0.667-5). The effective part of ginseng stems and leaves has the characteristics of exact active ingredient, simple composition, strong quality controllability, good product stability, small dosage, better pharmacological activity and the like. The preparation method comprises the step of separating and purifying ginsenoside Re and ginsenoside Rg1 as a whole, and the effective part of the ginseng stems and leaves has high ingredient stability, strong quality controllability, simple preparation process and high preparation efficiency, and is suitable for large-scale production.
Owner:成都普瑞法科技开发有限公司
Preparation method of morpholine derivative
The invention provides a preparation method of a morpholine derivative represented as the formula (I), wherein the preparation method includes the steps of: (1) dissolving trialkyl (aryl) phosphine, azodicarboxylic acid diester, (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl-1-ol, and (R)-4-benzyl-2-hydroxyl-morpholine-3-one in a reaction solvent; (2) adding the azodicarboxylic acid diester so that the trialkyl (aryl) phosphine and the azodicarboxylic acid diester are subjected to an addition reaction quickly in the reaction solvent to generate zwitter-ions, which are then converted into quaternary phosphonium salt by means of a hydrogen proton supplied by the hydroxyl group in the (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl-1-ol; (3) enabling the hydroxyl group on the 2-position of the (R)-4-benzyl-2-hydroxyl-morpholine-3-one to be reacted with the quaternary phosphonium salt to generate morpholine oxy-phosphonium salt; and (4) with the (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl-1-ol, which loses the hydrogen proton, as a nucleophilic reagent, performing an SN2 reaction with the morpholine oxy-phosphonium salt to obtain a product which has turned configuration. The method has high stereo-selectivity, avoids generation of an isomer byproduct during the reaction process, and reduces the load of separation and purification of the product in the later period.
Owner:江苏富泽药业有限公司
Improved preparation method of zirconium tetrachloride and zirconium tetrachloride
InactiveCN108793246AHigh purityReduce the difficulty of separation and purificationZirconium halidesCarbon dioxideOxide
The invention discloses an improved preparation method of zirconium tetrachloride and the zirconium tetrachloride. The preparation method comprises the following steps: 1), removing metal oxide impurities from zircon sand to obtain purified zircon sand; 2), heating the purified zircon sand together with a carbonaceous reducing agent and chlorine gas, reacting to produce zirconium tetrachloride, silicon tetrachloride, carbon monoxide and carbon dioxide and separating the zirconium tetrachloride. According to the preparation method, the metal oxide impurities in the zircon sand are removed firstand then the purified zircon sand reacts with the carbonaceous reducing agent and the chlorine gas, so that the content of chloride of the metal impurities in an obtained zirconium tetrachloride product is greatly reduced and the chloride of the metal impurities is avoided from entering the produced zirconium tetrachloride product, and thus the purity of the zirconium tetrachloride product is improved, the step of removing the chloride of the metal impurities is omitted, the separating and purifying difficulty of a back-end separation system is reduced, the purity and the quality of the zirconium tetrachloride product are improved, and the quality of a back-end product is improved.
Owner:XINTE ENERGY +1
Method for preparing tungsten pentachloride
ActiveCN108298586AImprove conversion rateAvoid decompositionTungsten halidesDeposition temperatureHydrogen
The invention discloses a method for preparing tungsten pentachloride. The method includes the steps of grinding and transferring raw material tungsten hexachloride into a reactor, introducing high-purity hydrogen to perform reduction reaction on tungsten pentachloride, wherein the reaction temperature is 280-400 DEG C, the reaction pressure is 0.01-0.5 MPa and the reaction duration is 2-5 s, andobtaining crude tungsten pentachloride with a concentration of 95% or above, wherein the conversion rate of tungsten pentachloride is larger than 80%; by sublimation and deposition, purifying the crude tungsten pentachloride, wherein the sublimation temperature is in a range of 200-250 DEG C, the deposition temperature is in a range of 100-150 DEG C, and the purity of the collected high-purity tungsten pentachloride can reach 99.99% or above. According to the method, the reduction reaction process is precisely regulated, the stability and purification rate of the product tungsten pentachlorideare improved, the method is simple, convenient, practical, high in controllability and low in cost, and large-scale industrial production is easy.
Owner:绿菱电子材料(天津)有限公司
Preparation method of plecanatide
PendingCN112940078ASimple ingredientsReduce the difficulty of separation and purificationPeptide preparation methodsBulk chemical productionPlecanatideFluid phase
The invention discloses a method suitable for industrially preparing pukanatide. According to the method, only two peptide fragments need to be prepared, the two peptide fragments are condensed into linear plecanatide through solid-phase synthesis, compared with a liquid-phase synthesis method, solution components are simpler, the separation and purification difficulty is lower, expensive enzymes are not needed, the cost is low, operation is convenient, and the method has high practical application value and is suitable for industrial production.
Owner:SICHUAN KELUN PHARMA RES INST CO LTD
Construction method and application of over-expressing fusA genetic engineering bacterium
ActiveCN104212756AIncrease productionReduce manufacturing costBacteriaMicroorganism based processesMicroorganismElongation factor
The invention relates to a construction method and an application of an over-expressing fusA genetic engineering bacterium, and belongs to the technical fieldof gene engineering and microbial fermentation. The method comprises the following steps: cloning elongation factor EF-G gene fusA through utilizing PCR amplification, connecting a gene fragment to an over-expression vector pDXW-8, electrically transferring to Corynebacterium glutamicum WY001, and carrying out antibiotic resistance screening to obtain the target engineering bacterium WY001 / pDXW-8-fusA. The Corynebacterium glutamicum gene engineering bacterium constructed in the invention can improve the output of amino acids in shake flask fermentation or fermentation cylinder fermentation, and is in favor of reducing the separation and purification difficulty and improving the yield in order to substantially reduce the production cost of the amino acids.
Owner:JIANGNAN UNIV
Method for extracting and purifying catalpol by use of active carbon column chromatography and crystallization technology
InactiveCN102408461ANo lossHigh puritySugar derivativesSugar derivatives preparationPurification methodsSolvent
The invention belongs to the technical field of medicines, and particularly relates to a method for separating and preparing catalpol from the tuberous root of a traditional Chinese medicine radix rehmanniae recens. The method takes the fresh tuberous root of the traditional Chinese medicine radix rehmanniae as a raw material, adopts a separation and purification method of active carbon column chromatography, and flexibly utilizes a solvent extraction method, a silica gel column separation method and various crystallization technologies to prepare catalpol products with different purities. The invention aims to provide a catalpol preparation method which has a simple process, is environment-friendly and energy-saving and is suitable for industrial production.
Owner:THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV
Synthetic method of 2,5-dichlorophenol
InactiveCN105801334AIncrease profitAvoid wastingOrganic compound preparationHalogenated hydrocarbon preparationChlorobenzeneEngineering
The invention relates to a synthetic method of 2,5-dichlorophenol, and belongs to the technical field of dicamba key intermediate synthesis. 1,2,4-trichlorobenzene generated by pure benzene chlorination can be easily separated from 1,4-dichlorobenzene to avoid high production cost and low production efficiency caused by difficulty in separation. Since the 1,2,4-trichlorobenzene and the 1,4-dichlorobenzene can independently obtain the 2,5-dichlorophenol, the use ratio of raw materials is high, the waste of a by-product is avoided, and therefore, the production cost is greatly lowered. In addition, the 1,4-dichlorobenzene can obtain the 2,5-dichlorophenol through two different methods. The synthetic method has the advantages of simple synthetic process, low production cost, high raw material use ratio, less process byproducts and small three-waste output and is more suitable for large-scale industrial production.
Owner:SICHUAN FOURSTAR BIOTECH RANDD CORP
A method for leaching and recovering valuable metals from cobalt-nickel-copper-manganese-iron alloy
The invention discloses a method for leaching and recovering valuable metals from a cobalt-nickel-copper-manganese-iron alloy, which comprises the following steps: (1) melting the cobalt-nickel-copper-manganese-iron alloy to form an alloy melt, wherein the cobalt-nickel-copper-manganese-iron alloy The mass fraction of manganese is not less than 5%; (2) adding silicon-containing material to the alloy melt while feeding gas to carry out blowing and slagging; (3) separating the obtained slag from the melt; ( 4) Atomizing the separated slag-forming melt into alloy powder, wherein the mass fraction of Mn in the alloy powder is 0.5%-20%; (5) Pickling the alloy powder to recover valuable metals. In the present invention, by adding silicon-containing materials and manganese in the cobalt-nickel-copper-manganese-ferroalloy, a low melting point and good fluidity MnO-SiO2 slag type is formed, so as to achieve the effect of manganese removal, with good manganese removal effect and less loss of valuable metals advantage.
Owner:CHANGSHA RES INST OF MINING & METALLURGY
Fusion polypeptide with antimicrobial and wound healing promoting function
InactiveCN101333258BReduce outputHas a lethal effectPeptide/protein ingredientsDermatological disorderAntimikrobielle peptideCell division
The invention relates to a fusion polypeptide with anti-bacterial and wound-healing promotion functions. The technical proposal adopted by the invention is that the fusion polypeptide with anti-bacterial and wound-healing promotion functions comprises a human epidermal growth factor of the amino acid sequence described in a sequence form SEQ ID NO.1, a thrombin protein cutting site of the amino acid sequence described in a sequence form SEQ ID NO.2, and a Rana chensinensis antimicrobial peptide of the amino acid sequence described in a sequence form SEQ ID NO.3; the thrombin protein cutting site enables the human epidermal growth factor to be fused with the Rana chensinensis antimicrobial peptide so as to construct a fusion polypeptide which has the amino acid sequence described in a sequence form SEQ ID NO.4. The fusion polypeptide of the invention has good stability and is provided with broad-spectrum antimicrobial and cell division promotional functions after digestion; the fusion polypeptide is infused in forms of gel agents and spraying agents and other agent types and can be applied to the burning, injury and other trauma treatment of human and mammals; the fusion polypeptide has the effects of preventing wound infection and accelerating wound healing.
Owner:LIAONING UNIVERSITY
Method for synthesizing polyquaternary ammonium salt
ActiveCN110724259AReduce order and symmetryReduce crystallinityEpoxy resin coatingsElectrically-conductive paintsChemistryEnvironmental chemistry
The invention relates to a method for synthesizing a polyquaternary ammonium salt. According to the method, an organic solvent, secondary amine, epihalohydrin, acid, strong-base anion exchange resin and the like serve as raw materials, the polarity of the secondary amine is lowered through increasing chain length of a hydrocabon group carbon chain in the secondary amine, thus, the polarity of thepolyquaternary ammonium salt is lowered, and the polyquaternary ammonium salt with good intermiscibility with epoxy resin and good anti-electrostatic property is synthesized. A polyquaternary ammoniumsalt macromolecular antistat is developed for epoxy resin coating materials. The method has the characteristics that the energy consumption is low, the environmental pollution is light, the production process is simple and is short in rout, the investment of large-scale production is small, and the production efficiency is high, so that the industrialization prospect is good.
Owner:NANJING FORESTRY UNIV
Preparation of glycolipid type ionic liquid and application of glycolipid type ionic liquid in glycolipid separation process
ActiveCN113603733ANovel structureHigh boiling pointSugar derivativesOrganic compound preparationRhamnolipidChemical compound
The invention provides glycolipid type ionic liquid prepared by using rhamnolipid fermentation liquor and a preparation process and application of the glycolipid type ionic liquid. The preparation process comprises the following steps of: filtering the rhamnolipid fermentation liquor to obtain rhamnolipid sterile liquid; adding acid into the sterile liquid, and collecting precipitate to obtain solid rhamnolipid; and mixing the rhamnolipid with a dialkyl amine compound, adding a solvent, standing for layering, and separating to obtain the rhamnolipid ionic liquid. The ionic liquid provided by the invention is novel in structure, has high solubility and stability to glycolipid besides chemical inertness, high boiling point and good electrical conductivity of the ionic liquid, and is immiscible with water, so that the separation of the glycolipid from the fermentation liquor becomes simpler, and the difficulty of separation and purification of the glycolipid is greatly reduced.
Owner:WANHUA CHEM (SICHUAN) CO LTD +1
A method for leaching valuable metals from cobalt-copper white alloy
ActiveCN105063353BReduce lossesAchieve the effect of removing siliconProcess efficiency improvementMetal leachingSlag
The invention discloses a method for leaching valuable metal from cobalt-copper white alloy. The method includes the following steps that (1) the cobalt-copper white alloy is melted into an alloy melt, wherein the cobalt-copper white alloy contains silicon and almost contains no manganese; (2) a Mn-containing material is added into the alloy melt, and meanwhile gas is led in for blowing and slagging; (3) obtained slag is separated from the melt; (4) the melt with the slag separated out is atomized into alloy powder, wherein the mass friction of Mn in the alloy powder is 0.5%-20%; and (5) the alloy powder is subjected to acid leaching, and the valuable metal is recovered. Due to the fact that the Mn-containing material is added and reacts with the silicon in the cobalt-copper white alloy to generate the MnO-SiO2 slag, the silicon removal effect is achieved, and the method has the beneficial effects of being good in silicon removal effect and small in valuable metal loss. Besides, the melting temperature is much lower than the melting point of CaO-(MgO)-SiO2 binary system or ternary system slag in the prior art.
Owner:CHANGSHA RES INST OF MINING & METALLURGY
A phosgenation reactor and a method for preparing isocyanates using the reactor
ActiveCN108079921BAvoid incomplete responseSmall particle sizeIsocyanic acid derivatives preparationOrganic compound preparationFluid phasePhysical chemistry
Owner:WANHUA CHEM GRP CO LTD
Microbial fuel cell for nitrogen and phosphorus removal of sewage treatment plant and sewage treatment method
InactiveCN112820924AReduce the difficulty of separation and purificationHigh purityWater contaminantsTreatment with anaerobic digestion processesMicrobial fuel cellBiofilm
The invention discloses a microbial fuel cell for nitrogen and phosphorus removal of a sewage treatment plant and a sewage treatment method. The microbial fuel cell comprises a nitrogen and phosphorus removal pool, the nitrogen and phosphorus removal pool is provided with a water inlet and a water outlet, and a nitrogen and phosphorus removal unit is arranged in the nitrogen and phosphorus removal pool; the nitrogen and phosphorus removal unit comprises an iron pole plate and a carbon felt which are sequentially arranged along the water flow direction in the nitrogen and phosphorus removal tank, a denitrification biological membrane is attached to the carbon felt, a collecting hopper and a sludge hopper are respectively arranged below the iron pole plate and the carbon felt in the nitrogen and phosphorus removal tank, and the iron pole plate is electrically connected with the carbon felt through a wire; and a resistor is connected in series on a lead connected between the iron polar plate and the carbon felt. According to the invention, nitrogen and phosphorus in the wastewater can be removed, the blue iron ore can be recycled, and the treatment target of combining wastewater treatment and resource recycling is achieved.
Owner:XI'AN UNIVERSITY OF ARCHITECTURE AND TECHNOLOGY
Method for extracting taxane active ingredients from Chinese yew efficiently
InactiveCN103408512BReduce usageReduce the difficulty of separation and purificationSugar derivativesSugar derivatives preparationOrganic solventBaccatin III
The invention discloses a method for extracting taxane type active ingredients from Chinese yew efficiently. The method comprises the following steps of: firstly extracting with water, further extracting with alcohol, and further purifying by a traditional purification method to get paclitaxel, 10-deacetyl baccatin III, taxol-7-xyloside, cephalomanine and other non-water-soluble taxane type substance monomers. According to the method disclosed by the invention, macroporous resin is applied to the extraction process, the extraction yield of the active ingredients is far higher than that of a traditional extraction method, the using quantity of an organic solvent is further significantly reduced, and the method is suitable for large-scale production of the paclitaxel and comprehensive extraction of other taxane active ingredient substances.
Owner:浙江大德龙生物技术有限公司
Preparation method of Stendra
ActiveCN109776505AReduce dosageHigh reactivityOrganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsPorphyrinCarboxylic acid
The invention provides a preparation method of Stendra. The method comprises the following steps that starting materials 4-[(3-chloro-4-methoxyphenyl)methylamino]-2-[(S)-2-hydroxymethyl pyrrole-1-base]pyrimidine-5-carboxylic acid and 2-pyrimidinemethanamine are dissolved into a reactive solvent methylbenzene, a boric acid porphyrin catalyst is aded, heating and stirring are conducted to a reflux state, and the Stendra is obtained through catalysis. Accordingly, boric acid porphyrin serves as the catalyst, catalysis is conducted directly to synthesize the Stendra directly. The dosage of the catalyst is low, the reaction activity is high, operation is relatively simple, after the reaction is finished, a target product is likely to be separated from the catalyst, the difficulty of separationand purification of later products is greatly lowered, the recovered catalyst can be recycled, and the preparation cost can be significantly lowered, and the whole catalytic reaction has the advantages of being simple, environmentally friendly and the like, the input cost such as manpower and raw materials is significantly lowered, and large-scale industrial production is facilitated.
Owner:扬州市三药制药有限公司
Method for synthesizing ademetionine by biological catalytic process
ActiveCN104178540AHigh activityHigh purityMicroorganism based processesFermentationEscherichia coliNanofiltration
The invention relates to a method for synthesizing ademetionine by a biological catalytic process, belonging to the technical field of biological pharmacy. The method comprises the following steps: inoculating Escherichia coli into a seed culture medium, carrying out shake culture over night, adding the over-night culture material into an LB (Langmuir-Blodgett) liquid culture medium, carrying out shake culture to mid-log phase, adding IPTG (isopropyl-beta-D-thiogalactopyranoside) into the bacterium liquid to fix the concentration, continuing carrying out shake culture and SAM synthetase expression, centrifuging to obtain wet bacteria, stirring for extraction treatment, loading to an ion exchange resin column, concentrating by nanofiltration, crystallizing, and carrying out vacuum drying to obtain the crystal. The technical scheme has the advantages of high conversion rate, short period, high purity and the like.
Owner:ZHEJIANG ZHENYUAN PHARMA CO LTD
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