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Method and kit for determining fluorine ions

A fluoride ion and kit technology is applied in the field of naphthalimide compounds as fluoride ion fluorescent probes, which can solve problems such as difficulty in fluoride ion detection, and achieve the effects of good stability and simple synthesis.

Inactive Publication Date: 2016-10-05
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The appropriate concentration of fluoride ions in drinking water is 0.5-1.0mg / L, which brings great difficulties to the detection of fluoride ions. Therefore, it is necessary to develop analytical methods that can detect fluoride ions in living bodies with high sensitivity.

Method used

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  • Method and kit for determining fluorine ions
  • Method and kit for determining fluorine ions
  • Method and kit for determining fluorine ions

Examples

Experimental program
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Effect test

Embodiment 1

[0033]

[0034] (Scheme 1) Dissolve 283mg (1mmol) of azetyl-4-hydrazine-1,8-naphthalene dicarboxamide in 15mL of absolute ethanol, then add 173mg (1mmol) of p-hydroxybenzaldehyde to reflux for 6h, and then use a high-pressure pump to Carry out suction filtration, obtain filter cake, filter cake becomes our crude product. If you want to get a purer product, you can recrystallize the filter cake with a mixed system of dichloromethane and petroleum ether (for example, v / v, 1:5) to get a pure product. 321.2 mg of pure orange product was obtained with a yield of 82%.

[0035] (Scheme 2) Dissolve 283mg (1mmol) of azetyl-4-hydrazine-1,8-naphthalene dicarboxamide in 15mL of absolute ethanol, then add 224.9mg (1.3mmol) of p-hydroxybenzaldehyde to reflux for 6h, and then use The high-pressure pump performs suction filtration to obtain a filter cake, which becomes our crude product. If you want to get a purer product, you can recrystallize the filter cake with a mixed system of dich...

Embodiment 2

[0041] Figure 1(a) is the probe (10μM) added to F - Fluorescence spectra before and after (400μM), through the illustration we can see that the fluorescence changes are very obvious.

[0042] Figure 1(b) is the probe (10 μM) added to F - (400μM) before and after the absorption spectrum, we can clearly see the change of the absorption spectrum through the illustration, and through the change of color, it can be observed with the naked eye.

Embodiment 3

[0044] Figure 2a Different concentrations of F - (0-500μM) on the probe (10μM) fluorescence spectrum; Figure 2b Different concentrations of F - (0-500μM) to probe (10μM) ultraviolet absorption spectrum; Figure 2c Different concentrations of F - (0-60μM) vs probe (10μM) A 596 / A 476 satisfy a good linear relationship.

[0045] It can be seen that with the F in the probe solution - As the concentration increases, the fluorescence intensity gradually weakens, and at (0-60μM) F - Concentration range, F - concentration and A 596 / A 476 into a linear relationship. The appropriate concentration of fluoride ions in drinking water is 0.5-1.0 mg / L. Therefore, the probe of the present invention can more accurately determine the content of fluoride ions in the sample to be tested.

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Abstract

The invention relates to a method and kit for determining fluorine ions. Particularly, probes of the invention are naphthalimide compounds and may be used as a fluorine ion colorimetric probe for detecting fluorine ions. These probes may have one of the following advantages: fluorine ions are recognized highly selectively; fluorine ions may be responded quickly; fluorine ions may be analyzed highly sensitively; the probes with stable properties may be stored and used for a long time; the probes have high anti-interference capacity.

Description

technical field [0001] The invention relates to a naphthalimide compound used as a fluoride ion fluorescent probe, which can rapidly and sensitively recognize the fluoride ion with high selectivity, or it can measure the concentration of the fluoride ion in a sample. Background technique [0002] Fluorine is one of the important trace elements in the human body. Fluoride is closely related to human life activities and metabolism of teeth and bone tissue. A small amount of fluorine is conducive to the normal development of teeth, can promote the resistance of tooth enamel to bacterial acid corrosion, and prevent dental caries. Therefore, water treatment plants generally add a small amount of fluorine to tap water and drinking water. At the same time, fluoride is very helpful to the health of bones, especially the prevention of osteoporosis. The imbalance of fluoride ions in the human body will cause serious harm to the body, and the lack of fluoride in the teeth will lead to...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N21/33C07D221/14C09K11/06
Inventor 舒伟柳彩云朱宝存唐成城王作凯王雅伟
Owner UNIV OF JINAN
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