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Preparation method of microfluidic paper chip based on fluorine material with hydrophobic and oleophobic properties

A microfluidic paper chip, hydrophobic and oleophobic technology, which is applied in fluid controllers, chemical instruments and methods, and analysis through chemical reactions of materials, can solve the problems of low surface energy and difficult preparation of paper chips, and achieve Reduce volatilization loss, increase capillary driving force, and lighten the background color

Active Publication Date: 2018-04-17
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is precisely because of the low surface energy of fluorine materials that it is difficult to prepare paper chips by using printing, spraying and other methods.

Method used

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  • Preparation method of microfluidic paper chip based on fluorine material with hydrophobic and oleophobic properties
  • Preparation method of microfluidic paper chip based on fluorine material with hydrophobic and oleophobic properties
  • Preparation method of microfluidic paper chip based on fluorine material with hydrophobic and oleophobic properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: This method prepares a paper chip and uses it to detect glucose concentration example (1) Use Adobe Illustrator CS5 software on the computer to design the hydrophobic and oleophobic fluorine material drawing pattern of the microfluidic paper chip (the pattern style is as attached figure 1 shown). The dimensions are: sample injection area (diameter 6.0 mm); middle microchannel (width 4.0 mm, length 8.0 mm); reaction area (diameter 10.0 mm). Draw five identical figures in parallel.

[0049] (2) Solid fluorine-containing polymer materials The solution prepared by dissolving AD80X in liquid hydrofluoroether HFE-7100 is used as ink, the concentration is 12mg·mL -1 , to replace the ink in the marker pen.

[0050] (3) Replace the marker pen assembled in step (2) with the cutter, and use Adobe Illustrator CS5 software to control the marker pen on the cutting plotter. The marking pen has a fiber liquid storage bag and a hygroscopic pen tip.

[0051] (4) Use cuttin...

Embodiment 2

[0060] Embodiment 2: Test the tolerance situation of paper chip to surfactant and organic reagent

[0061] (1) Use Adobe Illustrator CS5 software on the computer to design the hydrophobic and oleophobic fluorine material drawing pattern of the microfluidic paper chip (the pattern style is as attached Figure 4 shown). The diameter of the round hole is: 10.0mm.

[0062] (2) Prepare paper chips according to steps (2), (3) and (4) in Example 1.

[0063] (3) In order to facilitate the observation of the resistance of the paper chips made of fluorine materials to organic solvents, 5 μL of methyl red dye was added dropwise to each well of the hydrophilic area to make the outline clearer.

[0064] (4) Test the resistance of the paper chip to 1) surfactant: a.5% SDS; 2) organic reagent: b.Ethanol; c.Dichloromethane and d.Dioxane. The experimental results are attached Figure 5 Shown: paper chip has good tolerance effect to 1) surfactant a.5%SDS; 2) organic reagent: b.Ethanol; Flo...

Embodiment 3

[0066] Example 3: Comparing the tolerance of fluorine material paper chips and wax paper chips to surfactant 5% SDS

[0067] (1) According to the steps (2), (3) and (4) in Example 1, prepare fluorine material paper chips. Pattern style as attached Image 6 -a shown. The diameter of the round hole is: 10.0mm.

[0068] (2) Use wax spray printing to prepare wax paper chips, and the patterns are as attached Image 6 As shown in -b, the diameter of the round hole is: 10.0mm.

[0069] (3) In order to observe the resistance of the fluoromaterial paper chip to 5% SDS, 5 μL of methyl red dye was added dropwise into the round hole of the hydrophilic area to make the outline clearer.

[0070] (4) Add 5% SDS surfactant dropwise to the hydrophilic area of ​​the paper chip respectively. At 1min, the integrity of the hydrophobic cofferdam of the fluorine material paper chip and the wax paper chip is good (see Image 6 -a-1min and 6-b-1min); at 5min, the integrity of the hydrophobic coff...

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Abstract

The invention discloses a preparingmethod for a hydrophobic and oleophobicmicrofluidics paper chip based on a fluorine material. The preparingmethod includes the following steps that fluorine material drawing patterns of the microfluidics paper chip are designed; a solution prepared from the fluorine material is used as ink and poured into a pen, the assembled pen is used for replacing a graver, and drawing software is used for controlling the pen of a cutting plotter; the cutting plotter is used for drawing the designed patterns on paper to form a hydrophobic and oleophobiccofferdam; indicating liquid needed by detection is dripped to all reaction regions and evaporated to be dry under the room temperature condition; the prepared microfluidics paper chip is cut along the outer edges of the patterns and stacked and assembled with plastic package films for plastic package. The prepared paper chip is used for detecting substances through a colorimetric method and is mainly used for reaction with obvious color difference before and after reacting, for example, the paper chip can be used for detecting substances such as glucose, protein and heavy metal ions.

Description

technical field [0001] The invention relates to a microfluidic chip processing technology, more specifically a processing method for applying a fluorine-containing polymer material with ultra-low surface energy on a paper chip to realize regionalized hydrophobic and oleophobic properties. Background technique [0002] Paper-based microfluidics, usually referred to as paper chip, uses paper (such as various filter papers, filter membranes, office paper, etc.) as the material for making chips, and uses some technical methods to form hydrophilic fluid on the paper. channels and hydrophobic cofferdams to obtain microfluidic paper chips with desired hydrophilic channels. Then, the sample preparation, separation, reaction, detection, and result analysis of biological, chemical, and medical analysis processes are realized on the chip. It is a simple platform that can simultaneously separate and analyze multiple substances. [0003] Different processing methods use different hydrop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00G01N21/78
CPCB01L3/5027B01L3/502707B01L2200/10B01L2300/0861B01L2300/126B01L2300/161B01L2400/0406G01N21/78
Inventor 张显波王金华李晓峰姚成陈国松张之翼
Owner NANJING TECH UNIV