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Method for detecting particle dissolution rate

A detection method and dissolution rate technology, which is applied in the field of detection of particle dissolution rate, can solve problems such as incompleteness, and achieve low cost, high accuracy and good reproducibility

Inactive Publication Date: 2016-10-12
湖南盟合投资管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the quality of broken wall decoction pieces is not perfect enough

Method used

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  • Method for detecting particle dissolution rate
  • Method for detecting particle dissolution rate
  • Method for detecting particle dissolution rate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Test on the relationship between the dissolved concentration of the broken pieces of coix seed and the shading ratio

[0030] 1) Take 2g of Coix Seed Broken Decoction Pieces, accurately weigh them, place them in a 100mL beaker, and slowly add 50mL of water accurately measured along the wall of the beaker;

[0031] 2) Stir vigorously the particles and solvent in the beaker for 5 minutes to disperse the particles; immediately after shaking, accurately measure 0.5mL, 1.0mL, 1.5mL, 2.0mL, 2.5mL, 3.0mL, 3.5mL, 4.0mL, 4.5 mL, 5.0mL particle dispersion into a 10mL volumetric flask;

[0032] 3) Take an appropriate amount of water to a constant volume, add the diluted particle dispersion to the injector of the Omega LS-609 laser particle size analyzer, operate according to the particle size distribution detection method, set the parameters of the laser particle size analyzer, and select the dispersion medium. Water", ultrasound for 30 seconds before measurement, and other pa...

Embodiment 2

[0036] Example 2 Test of the relationship between the dissolved concentration of cinnamon broken pieces and the shading ratio

[0037] 1) Take 2g of broken cinnamon pieces, accurately weigh them, and place them in a 100mL beaker. Slowly add 50mL of water accurately measured along the wall of the beaker;

[0038] 2) Stir vigorously the particles and solvent in the beaker for 5 minutes to disperse the particles; immediately after shaking, accurately measure 0.5mL, 1.0mL, 1.5mL, 2.0mL, 2.5mL, 3.0mL, 3.5mL, 4.0mL, 4.5 mL, 5.0mL particle dispersion into a 10mL volumetric flask;

[0039] 3) Take an appropriate amount of water to a constant volume, add the diluted particle dispersion to the injector of the Omega LS-609 laser particle size analyzer, operate according to the particle size distribution detection method, set the parameters of the laser particle size analyzer, and select the dispersion medium. Water", ultrasound for 30 seconds before measurement, and other parameters such as re...

Embodiment 3

[0043] Example 3 Test of the relationship between the dissolution time and the shading ratio of the broken pieces of coix seed

[0044] 1) Take 4g of Coix Seed Broken Decoction Pieces, accurately weigh it, and place it in a 250mL beaker, and slowly add precisely measured 90-100℃, 100mL water along the wall of the beaker;

[0045] 2) Stir the particles and solvent in the beaker clockwise at a speed of 2 turns per second for 1 minute, 2 minutes, 3 minutes, 5 minutes, and 10 minutes, then let stand for 30 seconds, and accurately measure the liquid 2cm from the liquid surface. Put 2.0mL into different volumetric flasks and observe the residual particles at the bottom of the cup;

[0046] 3) Adjust the volume of the particle dispersion to 10mL, add the diluted particle dispersion to the injector of the Omega LS-609 laser particle size analyzer, operate according to the particle size distribution detection method, set the parameters of the laser particle size analyzer, and the dispersion m...

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Abstract

The invention provides a method for detecting particle dissolution cases. The method comprises putting particles with the sizes of 0.1-1000 microns into a transparent container, adding a solvent into the container, carrying out stirring dissolution, taking a particle dispersion liquid, diluting the particle dispersion liquid through a solvent, adding the solution into a laser particle analyzer, detecting a shading ratio through a particle size distribution detection method and recording the shading ratio. The method is first disclosed, effectively detects particle dissolution cases, is accurate, convenient and simple and realizes a low cost. In actual detection, the method realizes unification of detection standards of the same type of particles obtained by different technologies, realizes quantification of a dissolution rate and degree, provides detection standards for the existing problems and effectively guarantees detection data accuracy.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine treatment, in particular to a method for detecting the dissolution rate of particles. Background technique [0002] With the development of medical science, the requirements for the quality and efficacy of medicines are increasingly strict. According to different medication requirements, medication routes, and differences in physical and chemical properties of medications, various pharmaceutical dosage forms can be made to meet clinical needs. The process by which the drug enters the blood from the medication part is called absorption. For solid preparations, the absorption process can be summarized into two steps: (1) the drug is released and dissolved from the dosage form; (2) the drug is absorbed through the biofilm. The first step is based on dosage form, and the second step is based on physiological factors. For the same drug, its absorption is usually proportional to the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/02
CPCG01N15/0211
Inventor 杨记宗王娜邱光升蒋英高小英
Owner 湖南盟合投资管理有限公司
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