Injection for treating traumatic brain injury and disturbance of consciousness after brain surgery and preparation method thereof

Abstract

The invention belongs to the technical field of medicine and particularly relates to injection liquid for treating brain traumas and disturbance of consciousness after a brain operation and a preparation method of the injection liquid. The injection liquid is mainly prepared from active ingredients including edaravone, sodium chloride, cysteine hydrochloride, disodium glycyrrhizinate, methylparaben, a pH regulation agent and injection water. The prepared injection liquid is free of bubbles, adhesion of bubbles on an ampoule mouth is avoided, the phenomenon that visible foreign matter is not qualified due to carbonization of medicine liquid in the high-temperature sealing process is effectively avoided, the injection liquid is stable in mass and simple in process, and it is inspected through long-term experiments that all indexes meet specifications.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an injection for treating traumatic brain injury and disturbance of consciousness after brain surgery and a preparation method thereof. Background technique [0002] Traumatic cerebral infarction (TCI) is one of the more serious complications of craniocerebral injury, especially the occurrence of large-scale infarction will aggravate the damage of brain function and seriously affect the prognosis of patients. For patients with craniocerebral injury, the symptoms and signs of cerebral infarction are masked by the symptoms of primary damage due to severe disturbance of consciousness, making early detection of TCI quite difficult. Cerebral infarction after craniocerebral injury often has an insidious onset, rapid progression, and is easily concealed by the symptoms of the primary injury. Especially in comatose patients, it is more difficult to find out, and treatment is...

AI Technical Summary

Problems solved by technology

[0022] However, the inventor discovered in the actual production that during the filling process of the medicinal liquid, the medicinal liquid will generate a large number of air bubbles, and the air bubbles will hang on the filling needle and cannot be eliminated in time, thus sticking to the mouth of the bottle. Edaravone injection The liquid is filled in ampoules, which will cause the cohesive liquid to be carbonized during the process of high-temperature melting and sealing, resulting in unqualified visible foreign matter.

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