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Azulene structure novel compound in portulaca oleracea and extraction and separation method of azulene structure novel compound

A separation method and chamomile blue technology are applied in the separation/purification of carbonyl compounds, food ingredients containing natural extracts, food science and other directions, which can solve the problems of low structural novelty and achieve environmental protection process methods, simple operation methods and high efficiency. fast effect

Active Publication Date: 2016-11-09
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Azulene structure novel compound in portulaca oleracea and extraction and separation method of azulene structure novel compound
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  • Azulene structure novel compound in portulaca oleracea and extraction and separation method of azulene structure novel compound

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Embodiment 1

[0028] The invention provides a new compound with azulene structure, the molecular formula is C 13 h 18 o 2 , the chemical structural formula is.

[0029]

[0030] The new compound of the azulene structure is named Oleracone B according to the structure, and Table 1 is the NMR data of the new compound of the azulene structure: 1 H-NMR with 13 C-NMR in CDCl 3 middle.

[0031] Table 1: NMR data of compound Oleracone B, a new compound with azulene structure of the present invention.

[0032]

[0033]

[0034] see Figure 1-10 , the structure identification and deduction of the new compound of azulene structure described in the present invention.

[0035] Oleracone B: Colorless oil, [α] 20 D 0(c 0.1, MeOH), easily soluble in chloroform and methanol, insoluble, slightly soluble in water. UV(MeOH)λ max :295nm, IRν O-H 3420, ν C＝O 1760, v C＝C 1659,1625,ν O-H 1310, ν C＝O 1203, # ＝CH 893cm -1 , HRESI(+)TOFMS gives m / z: 207.1389[M+H] + The quasi-molecul...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to an azulene structure novel compound extracted, separated and identified from the portulaca oleracea and an extraction and separation method of the azulene structure novel compound. The azulene structure novel compound of which the molecular formula is C13H18O2 is named as Oleracone B. The invention further provides the extraction and separation method of the novel compound. According to the method disclosed by the invention, decoction with water for extraction, ethyl acetate extraction, silica gel column chromatography, ODS (Octadecylsilyl) medium pressure column chromatography and SephadexLH-20 are sequentially performed, so that the azulene structure novel compound is successfully extracted and separated. The novel compound has the effects of resisting inflammation, alleviating pains and resisting tumors. The novel compound as well as salts or derivatives thereof can be used as synthesizing precursors of other compounds, and used as raw materials for developing new medicines and researching pharmacological activity, and used for preparing medicines or health products for resisting inflammation, treating pains and resisting tumors.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new compound with a chamomile structure extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [0003] Modern pharmacological studies of purslane have shown that it has the functions of anti-inflamma...

Claims

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Application Information

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IPC IPC(8): C07C49/733C07C45/78C07C45/79A61P29/00A61P35/00A23L33/105
CPCA23V2002/00C07C45/78C07C45/79C07C49/733A23V2200/308A23V2200/30A23V2250/21
Inventor 英锡相英哲铭李翠玉张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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