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Preparation method and application of ointment containing flusilazole

A technology of flusilazole ointment and flusilazole, which is applied in the field of preparation of ointment containing fluorosilazole, can solve the problems of slow healing of scars and wounds, easy recurrence, and bacterial infection, so as to reduce the probability of recurrence and recidivism. The effect of less pollution and strong permeability

Inactive Publication Date: 2016-11-23
QINGDAO STAR CROPSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The smears currently used, such as octoprodil, copper methamine, and humic copper sulfate, have shortcomings such as incomplete sterilization, easy recurrence, and slow healing of scars and wounds on the healing of scars. The bark around the scar is corroded, and new wounds are created during the prevention and treatment process, which leads to the re-infection of bacteria
The use of flusilazole ointment to control apple tree rot has not been reported at home and abroad

Method used

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  • Preparation method and application of ointment containing flusilazole
  • Preparation method and application of ointment containing flusilazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 5% flusilazole ointment

[0024] Product formula (take 100kg as an example):

[0025] Flusilazole: 5% (added after discount)

[0026] Soybean Oil: 30%

[0027] Polymaleic anhydride: 7%

[0028] Diethanolamide Monoglyceride Stearate: 10%

[0029] Glucose: 5%

[0030] Pine base oil: 5%

[0031] Xanthan Gum: 2%

[0032] Sodium Benzoate: 1%

[0033] Water: make up to 100%

[0034] Preparation:

[0035] In the paste making container, add measured flusilazole 5kg, then add soybean oil 30kg, glucose 5kg, polymaleic anhydride 7kg, xanthan gum 2kg, pine base oil 5kg in batches, and carry out homogeneous stirring and grinding at the same time, Fully knead the materials; finally add 10kg of diethanolamide monoglyceride stearate, 1kg of sodium benzoate, and 35kg of water, and fully knead to a paste shape. After passing the test, cool naturally and age to form a homogeneous Bonded body, namely 5% flusilazole ointment.

Embodiment 2

[0036] Example 2 10% flusilazole ointment

[0037] Flusilazole: 10% (added after discount)

[0038] Rapeseed Oil: 25%

[0039] Modified sodium polyacrylate: 5%

[0040] Polyethylene glycol: 4%

[0041] Sodium lignosulfonate: 8%

[0042] Silica: 7%

[0043] Urea: 5%

[0044] Pine base oil: 5%

[0045] Sodium Benzoate: 0.8%

[0046] Water: make up to 100%

[0047] Preparation:

[0048] In the paste making container, add measured flusilazole 10kg, then add rapeseed oil 25kg, white carbon black 7kg, urea 5kg, modified sodium polyacrylate 5kg, polyethylene glycol 4kg, pine base oil 5kg in batches, At the same time, carry out homogeneous stirring and grinding to make the materials fully kneaded; finally add 8 kg of sodium lignosulfonate, 0.8 kg of sodium benzoate, and 30.2 kg of water, and fully knead to a paste shape. After passing the test, naturally cool and age to make After the material is fully expanded, a homogeneous cohesive body is formed, and a 10% flusilazole...

Embodiment 3

[0049] Example 3 20% flusilazole ointment

[0050] Flusilazole: 20% (added after discount)

[0051] Flax Oil: 18%

[0052] Rapeseed Oil: 10%

[0053] Sodium carboxymethyl cellulose: 4%

[0054] Gelatin: 4%

[0055] Fatty alcohol polyoxyethylene ether: 10%

[0056] Magnesium Aluminum Silicate: 3%

[0057] Soluble starch: 5%

[0058] Pine base oil: 3%

[0059] Sodium Benzoate: 1.5%

[0060] Water: make up to 100%

[0061] Preparation:

[0062] In the paste making container, add 20kg of measured flusilazole, then add 18kg of flax oil, 10kg of rapeseed oil, 3kg of magnesium aluminum silicate, 5kg of soluble starch, 4kg of sodium carboxymethylcellulose, 4kg of gelatin, pine base Oil 3kg, at the same time carry out homogeneous stirring and grinding, so that the materials are fully kneaded; finally add fatty alcohol polyoxyethylene ether 10kg, sodium benzoate 1.5kg, water 21.5kg, fully knead to a paste shape, after passing the test, cool naturally, and age Make the mate...

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PUM

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Abstract

The invention discloses a flusilazole ointment. The flusilazole ointment contains 1%-30% of effective ingredients by mass and is supplemented by a proper amount of vegetable oil, high-molecular polymers, a surfactant, filler, sodium benzoate, a solvent and water. The invention further provides a preparation method of the flusilazole ointment and an application of the flusilazole ointment in prevention and treatment of apple rot. The flusilazole ointment has the benefits as follows: the provided flusilazole ointment is easy to degrade and lower in toxicity and causes no pollution to soil and trees; compared with mineral oil, the vegetable oil used in a matrix is easy to degrade and causes little pollution to the environment; flusilazole is taken as an effective ingredient, and the flusilazole ointment has protection and treatment functions and has high permeability; with the adoption of an ointment smearing mode, rot germs at a scar are thoroughly killed, and the probability of relapse of the scar is reduced.

Description

technical field [0001] The invention belongs to the technical field of new formulations of pesticides, and in particular relates to a preparation method and application of a silazole-containing ointment. Background technique [0002] Fluorosilazole: chemical name: bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-ylmethylene)silane, its structural formula is as follows: [0003] [0004] The original drug is a colorless crystal with a melting point of 53°C and a vapor pressure of 3.9×10^ ( － 5) Pa(25℃), solubility in water 45(pH7.8), 54(pH7.2), 900(pH1.1) (mg / L, 20℃), soluble in most organic solvents (>2kg / L), generally It can be stored for more than 2 years under storage conditions and decomposes above 310°C. Stable to light. [0005] Flusilazole is a triazole fungicide, and its main mechanism of action is to destroy and prevent the biosynthesis of ergosterol, an important component of the cell membrane of germs, resulting in the failure of cell membrane formation and...

Claims

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Application Information

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IPC IPC(8): A01N55/10A01N25/02A01P3/00
Inventor 李国安郭坤燕
Owner QINGDAO STAR CROPSCI