Roxithromycin capsules and preparation process thereof

A technology of roxithromycin and preparation process, which is applied in the directions of capsule delivery, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low reliability of preparation process, insoluble roxithromycin, Problems such as poor particle fluidity, to achieve the effect of good fluidity, low cost and high production efficiency

Inactive Publication Date: 2016-11-23
浙江花园药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing chewable aluminum carbonate tablets have poor taste, and the existing chewable aluminum carbonate tablets have the problems of low reliability of the preparation process, many procedures, and low work efficiency
In the preparation process of the existing roxithromycin capsules, the problem of roxithromycin insolubility in water, uneven mixing in the tablet, drug dissolution, and poor particle fluidity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Roxithromycin capsules, the raw materials of the roxithromycin capsules include roxithromycin, starch, low-substituted hydroxypropyl cellulose, polysorbate, sodium starch glycolate, and silicon dioxide.

[0021] The preparation technology of roxithromycin capsule, its concrete steps are as follows:

[0022] (1), by weight, weigh 1500 grams of roxithromycin, 430 grams of starch, and 86 grams of low-substituted hydroxypropyl cellulose, and then mix them evenly;

[0023] (2), add polysorbate 20 grams by weight;

[0024] (3) Add ethanol and mix well again;

[0025] (4) Pass through a 18-mesh sieve to make granules;

[0026] (5) Drying, drying at a temperature of 60°C;

[0027] (6), granulate through 18-mesh sieve;

[0028] (7) Add 100 grams of sodium starch glycolate and 42.7 grams of silicon dioxide in parts by weight, and mix well;

[0029] (8), pack into capsules to obtain roxithromycin capsules.

[0030] The present invention is convenient to take raw materials, t...

Embodiment 2

[0032] Roxithromycin capsules, the raw materials of the roxithromycin capsules include roxithromycin, starch, low-substituted hydroxypropyl cellulose, polysorbate, sodium starch glycolate, and silicon dioxide.

[0033] The preparation technology of roxithromycin capsule, its concrete steps are as follows:

[0034] (1), by weight, weigh 150 grams of roxithromycin, 43 grams of starch, and 8.6 grams of low-substituted hydroxypropyl cellulose, and then mix them evenly;

[0035] (2), add polysorbate 2 grams by weight;

[0036] (3) Add ethanol and mix well again;

[0037] (4) Pass through a 18-mesh sieve to make granules;

[0038] (5) Drying, drying at a temperature of 60°C;

[0039] (6), granulate through 18-mesh sieve;

[0040] (7) Add 10 grams of sodium starch glycolate and 4.27 grams of silicon dioxide in parts by weight, and mix well;

[0041] (8), pack into capsules to obtain roxithromycin capsules.

[0042] The present invention is convenient to take raw materials, the ...

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PUM

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Abstract

The invention discloses a roxithromycin capsule and a preparation process thereof. The raw materials include roxithromycin, starch, low-substituted hydroxypropyl cellulose, polysorbate, sodium carboxymethyl starch and silicon dioxide. The preparation process of roxithromycin capsules: (1), by weight, weigh 1500 parts of roxithromycin, 430 parts of starch, and 86 parts of low-substituted hydroxypropyl cellulose, and then mix them uniformly; (2), by weight Add 20 parts of polysorbate; (3), add ethanol, and mix again; (4), make granules through a 18-mesh sieve; (5), dry; (6), granulate through a 18-mesh sieve; (7) 100 parts by weight of sodium starch glycolate and 42.7 parts of silicon dioxide were added, and mixed evenly; (8), packed into capsules to obtain roxithromycin capsules. The invention is convenient to take raw materials, the cost of the roxithromycin capsule is low, the process is simple, the reliability is high, and the production efficiency is high.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to roxithromycin capsules and a preparation process thereof. Background technique [0002] The existing chewable palate has poor taste, and the existing chewable palate has the problems of low reliability of the preparation process, many procedures and low work efficiency. In the preparation process of the existing roxithromycin capsules, the roxithromycin has the problem of insolubility in water, uneven mixing in the tablet, drug dissolution, and poor particle fluidity. Contents of the invention [0003] The purpose of the invention is to overcome the deficiencies in the existing products and provide a roxithromycin capsule and a preparation process thereof. [0004] In order to achieve the above object, the present invention is achieved through the following technical solutions: [0005] Roxithromycin capsules, the raw materials of the roxithromycin capsule...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/7048A61K47/38A61K47/36A61K47/26A61K47/04A61P31/04
CPCA61K31/7048A61K9/4866
Inventor 郎明洋
Owner 浙江花园药业有限公司
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