Application of mesenchymal stem cells in preparing medicine for treating neurodegenerative diseases
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
- Publication Date
- 2016-11-23
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Abstract
Description
technical field
[0001] The invention belongs to the field of biomedicine, and more specifically, the invention relates to the application of mesenchymal stem cells in the preparation of drugs for treating neurodegenerative diseases. Background technique
[0002] Parkinson's disease and Parkinson's syndrome (parkinson disease, PD) is a common neurodegenerative disease, and its characteristic pathological change is the progressive loss of dopamine (DA) neurons in the substantia nigra of the midbrain. This in turn leads to a decrease in dopamine neurotransmitters projecting to the striatum. Genetic factors, environmental factors, aging, oxidative stress, and inflammation are all involved in the degeneration and death process of dopaminergic neurons in Parkinson's disease. Among them, oxidative stress plays a dominant role in various neurodegenerative mechanisms and plays an important role in the death of dopamine neurons. At present, there is still no effective treatment for ...