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A device for removing cell micelles from cell preparations

A cell preparation and cell technology, applied in the field of biomedicine, can solve problems such as blood vessel blockage, embolism, and cells cannot be effectively cleaned, and achieve the effects of small resistance, speeding up filtration, and preventing water leakage and cracking.

Active Publication Date: 2018-12-11
天晴干细胞股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although most cell medicines are transfused back into the human body, they use a blood transfusion set with a 70-mesh filter, but because the filter is relatively thick, it can effectively remove large particles. The cells in the cluster cannot be effectively cleaned up, and during the reinfusion process, they will still enter the infusion tube and be reinfused into the body, causing possible clinical risks such as blood vessel blockage and embolism

Method used

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  • A device for removing cell micelles from cell preparations
  • A device for removing cell micelles from cell preparations
  • A device for removing cell micelles from cell preparations

Examples

Experimental program
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specific Embodiment approach 1

[0030] Specific implementation mode one: combine Figures 1 to 2 Describe this embodiment, a device for removing cell micelles in cell preparations according to this embodiment, which includes a needle 1, a cell filter 2, a medical three-way valve 3, a syringe 4 and a reinfusion bag 5;

[0031] The cell filter 2 has an elliptical cavity structure, and a cell filter membrane 2-1 of 70 mesh and a cell filter membrane of 200 mesh-2- 2 and 200 mesh cell filter membrane two 2-3; a stirrer 7 is arranged at the liquid inlet of the cell filter 2;

[0032] The medical three-way valve 3 is composed of a three-way valve core 3-1, a first interface 3-2, a second interface 3-3 and a third interface 3-4; the reinfusion bag 5 is provided with heparin cap6;

[0033] The liquid outlet of the needle 1 is connected with the liquid inlet of the cell filter 2, the liquid outlet of the cell filter 2 is connected with the first interface 3-2, and the second interface 3-3 is connected with the liqu...

specific Embodiment approach 2

[0034] Specific implementation mode two: combination Figures 1 to 2 This embodiment is described. The first difference between this embodiment and the specific embodiment is that the syringe 4 and the third interface 3-4 are connected by threads. Other compositions and connection methods are the same as those in Embodiment 1.

specific Embodiment approach 3

[0035] Specific implementation mode three: combination Figures 1 to 2 This embodiment is described. The first difference between this embodiment and the specific embodiment is: the needle 1 , the cell filter 2 , the medical three-way valve 3 and the reinfusion bag 5 are integrally connected. Other compositions and connection methods are the same as those in Embodiment 1.

[0036] Specific implementation mode four: combination Figures 1 to 2 Describe this embodiment, the difference between this embodiment and specific embodiment 1 is: the needle 1, the cell filter 2, the medical three-way valve 3 and the reinfusion bag 5 are connected by a hose, and the hose is a high-performance polyolefin Thermoplastic elastomer material. Other compositions and connection methods are the same as those in Embodiment 1.

[0037] Specific implementation mode five: combination Figures 1 to 2 Describe this embodiment, the difference between this embodiment and specific embodiment 1 is: the ...

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Abstract

The invention relates to a device for removing cell micelles from a cell preparation. The device comprises a filter unit, an injector and a feedback bag, wherein the filter unit comprises a needle head, a cell filter and a medical three-way valve. The cell filter is an elliptical cavity structure, the inside of the cell filter cavity is sequentially provided with a 70-mesh cell filter membrane, a 200-mesh cell filter membrane and a 200-mesh cell filter membrane side by side from the liquid inlet to the liquid outlet; when the cell feedback preparation is conveyed to the specified feedback site, no clean-level environment is needed; and in a common region, the closed system can be utilized to remove the micelle cells safely and quickly, thereby implementing secure cell drug feedback.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a device for removing cell micelles in cell preparations, which is an auxiliary device before the clinical use of cell products. Background technique [0002] Cellular medicine is one of the more effective treatment methods for many diseases today. In many fields such as tumor treatment, anti-aging, and sub-health, using cells as therapeutic drugs is one of the future clinical development directions. Cytokine induced killer cells (CIK) therapy is one of the most mature methods in the field of tumor biotherapy. Natural killer cells (NK) therapy is a cell biological therapy that is widely used in Europe, America and Japan. Compared with other cellular immunotherapy, NK recognition of tumor cells is not restricted by MHC and does not need to be activated in vitro It can directly achieve the purpose of tumor killing. Chimeric antigen receptor T-cell (CAR-T) technology is a hot ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00C12M1/12A61M5/14A61M5/165
CPCA61M5/14A61M5/165A61M2005/1401A61M2005/1657C12M47/04
Inventor 李琳张怡车彦川王浩宇刘艳青
Owner 天晴干细胞股份有限公司
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