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A miniature nuclear magnetic resonance probe

A kind of nuclear magnetic resonance and micro technology, applied in the direction of using nuclear magnetic resonance for analysis, can solve the problems of cross-contamination of samples, non-replacement of the probe detection cavity, etc., to achieve the effect of improving production efficiency, simple and reliable manufacturing process, and reducing manufacturing cost.

Active Publication Date: 2018-06-29
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, it is difficult to solve the problems of time-consuming cleaning of the detection chamber and cross-contamination of samples caused by the non-replaceable detection chamber of the probe, which is especially prominent when detecting ultra-low concentration samples

Method used

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  • A miniature nuclear magnetic resonance probe
  • A miniature nuclear magnetic resonance probe
  • A miniature nuclear magnetic resonance probe

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Experimental program
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Effect test

Embodiment

[0030] See figure 2 and Figure 6, a kind of nuclear magnetic resonance probe that utilizes disposable chips provided in this case, the use process is as follows: 1. Adopt the commonly used de-embedding method, utilize the first pad 333 and the second pad 334 to access the impedance analyzer, test the present invention The impedance value of the Helmholtz coil composed of the middle and upper layer coil 12, the lower layer coil 32, the upper layer wire 13, the lower layer wire 33, the first conductive column 41 and the second conductive column 42 at the Larmor frequency; 2, access to the actual circuit , use the L-type oscillating circuit to match to 50 ohms; 3. Place the tuned probe in the main magnetic field, which is mainly the static magnetic field provided by the permanent magnet; 4. Pass the liquid sample through the sample inlet 51 into the unused sample-loading chip for detection Cavity 53, continuously and stably lead to the sample outlet 52, a small amount of sampl...

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Abstract

The invention discloses a mini nuclear magnetic resonance (NMR) probe. The probe comprises a probe body and a detection channel arranged in the probe body. The detection channel comprises a sample inlet, a sample outlet, and a detection cavity, which is arranged between the sample inlet and the sample outlet. The probe is characterized in that the probe body comprises a probe upper layer, a middle layer spacer, and a probe lower layer; a chip groove that can be communicated with the exterior of the probe body is arranged on the middle layer spacer, a carrier chip is arranged in the chip groove, the detection channel is arranged on the carrier chip; the probe upper layer is provided with an upper layer coil, the probe lower layer is provided with a lower layer coil, the upper layer coil and the lower layer coil are electrically connected; the detection cavity is arranged between the upper layer coil and the lower layer coil, and the detection cavity, the upper layer coil, and the lower layer coil are concentric. The provided mini NMR probe can detect a micro-sample, the sample will not be left on the probe, the probe will not be polluted, and thus detection signals, which are more precise and reliable, can be obtained.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance probe, in particular to a miniature nuclear magnetic resonance probe using a disposable chip. Background technique [0002] Nuclear magnetic resonance imaging and nuclear magnetic resonance spectroscopy, as the two most general and signal-rich detection methods, are widely used in the fields of chemistry, pharmacy, biology and medicine. Due to the non-invasiveness of this technology, it is especially suitable for biological Sample testing. According to the classic signal-to-noise ratio formula (Hoult D I, Richards R E. The signal-to-noiseratio of the nuclear magnetic resonance experiment. 1976. [J]. Journal of Magnetic Resonance, 2011, 213 (2): 329-43.) It can be seen that when the detected sample body is relatively small, the sensitivity of NMR detection can be greatly improved. To this end, scholars have made many attempts, such as Roger et al. (Using microcontactprinting to fabricate microcoils...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N24/08
CPCG01N24/08
Inventor 倪中华易红雷鹏坤陆荣生周新龙
Owner SOUTHEAST UNIV
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