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Preparation method of glass wound protective gel

A gel and wound surface technology, applied in the field of medical products, can solve problems such as severe pain, rapid increase of local pH, and patient irritation, and achieve the effect of no side effects, good repair effect, and convenient use

Inactive Publication Date: 2016-12-14
JIANGSU LANWAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the dressings containing bioactive glass are applied to the wound surface. When the bioactive glass particles contact with the liquid, a rapid reaction occurs on the surface, causing a rapid increase in local pH. come some pain

Method used

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  • Preparation method of glass wound protective gel

Examples

Experimental program
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Effect test

Embodiment 1

[0017] A preparation method of glass wound protection gel, comprising the following steps:

[0018] Step 1, add 0.5 parts of gelatin and 1 part of gum arabic in parts by weight to 20 parts of water for injection, heat and stir to mix evenly, the heating temperature is 60°C, the stirring speed is 80 rpm, and the stirring time is 30 minutes, and then Add 2 parts of aloe extract and 1 part of lecithin, continue to stir and mix evenly to obtain a mixed solution 1;

[0019] Step 2, 0.2 part of polyethylene glycol 600, 5 parts of sodium hyaluronate gel, 3 parts of bioactive glass powder, 0.1 part of sodium acetate, 0.5 part of microcrystalline cellulose and hypromellose in parts by weight Add 1 part to 5 parts of water for injection, heat and stir for 20 minutes under a vacuum condition of 0.02 MPa, the heating temperature is 30°C, and the stirring speed is 60 rpm to obtain the mixed solution 2;

[0020] Step 3: Heat the mixed solution 1 to 40° C., add the mixed solution 2 under st...

Embodiment 2

[0022] A preparation method of glass wound protection gel, comprising the following steps:

[0023] Step 1, add 0.6 parts of gelatin and 2 parts of gum arabic in parts by weight to 25 parts of water for injection, heat and stir to mix evenly, the heating temperature is 63°C, the stirring speed is 85 rpm, the stirring time is 36 minutes, and then Add 3 parts of aloe extract and 2 parts of lecithin, continue to stir and mix evenly to obtain a mixed solution 1;

[0024] Step 2, 0.3 part of polyethylene glycol 600, 7 parts of sodium hyaluronate gel, 5 parts of bioactive glass powder, 0.2 part of sodium acetate, 0.6 part of microcrystalline cellulose and hypromellose in parts by weight Add 2 parts to 7 parts of water for injection, heat and stir for 25 minutes under a vacuum condition of 0.06MPa, the heating temperature is 36°C, and the stirring speed is 65 rpm to obtain the mixed solution 2;

[0025] Step 3: Heat the mixed solution 1 to 42°C, add the mixed solution 2 under stirri...

Embodiment 3

[0027] A preparation method of glass wound protection gel, comprising the following steps:

[0028] Step 1, add 0.8 parts of gelatin and 2 parts of gum arabic in parts by weight to 28 parts of water for injection, heat and stir to mix evenly, the heating temperature is 67°C, the stirring speed is 95 rpm, the stirring time is 45 minutes, and then Add 5 parts of aloe extract and 3 parts of lecithin, continue to stir and mix evenly to obtain a mixed solution 1;

[0029] Step 2, 0.4 part of polyethylene glycol 600, 8 parts of sodium hyaluronate gel, 6 parts of bioactive glass powder, 0.2 part of sodium acetate, 0.7 part of microcrystalline cellulose and hypromellose in parts by weight Add 2 parts to 9 parts of water for injection, heat and stir for 26 minutes under a vacuum condition of 0.04MPa, the heating temperature is 38°C, and the stirring speed is 65 rpm to obtain the mixed solution 2;

[0030] Step 3: Heat the mixed solution 1 to 48°C, add the mixed solution 2 under stirri...

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Abstract

The invention discloses a preparation method of glass wound protective gel. The preparation method comprises the following steps: adding gelatin and Arabic gum into water for injection, heating, stirring and mixing uniformly, adding an aloe extract and lecithin, and continuously stirring and mixing uniformly to obtain a mixed liquid I; adding polyethylene glycol, sodium hyaluronate gel, bioactive glass powder, sodium acetate, microcrystalline cellulose 0 and hydroxypropyl methylcellulose into water for injection, and heating and stirring under a vacuum condition to obtain a mixed liquid II; finally heating the mixed liquid I, adding the mixed liquid II under a stirring condition, continuously stirring for a certain time after adding all the mixed liquid II, and standing at the temperature of 4 DEG C for 3 to 5 hours to obtain the glass wound protective gel. The glass wound protective gel obtained by the method provided by the invention can quickly repair the surface wound and does not generate side effects.

Description

technical field [0001] The invention belongs to the field of medical products, and in particular relates to a preparation method of a glass wound protection gel. Background technique [0002] Bioactive glass (bioactiveglass, BAG), which is made of SiO 2 , Na 2 O, CaO and P 2 o 5 Silicate glass composed of basic components. The most notable feature of bioactive glass and glass ceramics is that after being implanted into the human body, the surface condition changes dynamically over time, and a bioactive hydroxycarbonate apatite (HCA) layer forms on the surface, providing a bonding interface for tissues. Most bioactive glasses are Class A bioactive materials, which have both osteoproductive and osteoconductive effects, and have good integration with bone and soft tissue. BAG is considered to be applicable in the field of repair good biological material. This restorative material is not only widely used, but also has irreplaceable magical effects in professional products ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0057A61L26/0004A61L26/0019A61L26/0023A61L26/0038A61L26/008C08L89/06C08L5/00C08L5/08C08L1/04C08L1/284C08L71/00
Inventor 章祥庆唐海健
Owner JIANGSU LANWAN BIOTECH
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