Tandem type full-field optical tomography imaging device and method based on compensation interferometer

Abstract

The invention discloses a tandem type full-field optical tomography imaging device and a tandem type full-field optical tomography imaging method based on a compensation interferometer. The device comprises a broadband halogen light source, a kohler illuminating system, the compensation interferometer, a second beam splitter prism, a detection interferometer, a sample, an imaging lens and an area array CCD. The method comprises the following steps: light emitted by the broadband halogen light source enters the compensation interferometer through the kohler illuminating system; the light reflected by each of two arms of the compensation interferometer is divided into two light beams by the second beam splitter prism; one beam enters the detection interferometer; part of the light entering the detection interferometer is reflected, and the other part of the light penetrates through the detection interferometer to illuminate the sample; the light reflected by the detection interferometer is used as reference light; the reference light meets backwards scattered light of the sample to generate interference; after passing through the second beam splitter prism, an interference signal is focused onto the area array CCD through the imaging lens. The tandem type full-field optical tomography imaging device has the characteristics of convenience for operation, high resolution, high imaging speed, compact structure and convenience for hand holding and internal observation.

Description

technical field [0001] The invention relates to the technical field of full-field optical coherence tomography, in particular to a tandem full-field optical tomography device and method based on a compensation interferometer. Background technique [0002] Optical coherence tomography (OCT) is an optical tomography technology developed rapidly in the past 20 years. It reconstructs sample information through the interference of reference light and sample scattered light to achieve the effect of optical sectioning. Because OCT uses a low-coherence light source, its resolution is high and can reach the micron level. Compared with traditional biomedical imaging technology, OCT technology has the advantages of no damage, high sensitivity, and real-time imaging, and is widely used in biomedical and material science fields. Based on the existing OCT technology, full-field optical coherence tomography (FF-OCT) has been developed, which uses low-coherence light source and high NA mic...

AI Technical Summary

Problems solved by technology

Although the SLD light source with a central wavelength of 830nm can better image biological tissues, its bandwidth (tens of nm) is smaller than that of thermal light sources such as halogen lamps (bandwidth is generally hundreds of nm), which limits the system Axial resolution

Xenon arc lamps can provide better illumination and incident power than thermal light sources, but their bandwidth is still small, and the axial resolution is generally in the tens to several μm

At the same time, the numerical aperture of the detection interferometer objective lens is small, and the lateral resolution is affected

Combining the xenon arc lamp and the optical fiber imaging bundle with a large numerical aperture can obtain micron-level lateral and axial resolution, but there is still a big gap from the 1-micron-level resolution of the traditional FF-OCT system

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