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Method for preparing drug-loaded aortic valve based on 3D printing and drug-loaded aortic valve

An aortic valve, 3D printing technology, applied in heart valves, additive processing, etc., can solve problems such as poor, long-term anticoagulation treatment durability, etc., to reduce production costs, personalize bionic performance, and solve long-term resistance. coagulation effect

Active Publication Date: 2018-01-30
广州尤尼智康生物科技有限公司
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Problems solved by technology

[0005] This application provides a method for preparing a drug-loaded aortic valve based on 3D printing and a drug-loaded aortic valve, which solves the technical problems of long-term anticoagulant therapy and poor durability in existing valve replacements

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  • Method for preparing drug-loaded aortic valve based on 3D printing and drug-loaded aortic valve
  • Method for preparing drug-loaded aortic valve based on 3D printing and drug-loaded aortic valve
  • Method for preparing drug-loaded aortic valve based on 3D printing and drug-loaded aortic valve

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Embodiment Construction

[0023] The specific implementation manners of the present application will be described in further detail below in conjunction with the accompanying drawings.

[0024] This application aims to provide a method for preparing a drug-loaded aortic valve based on 3D printing and a drug-loaded aortic valve to solve the technical problems of long-term anticoagulation treatment and poor durability in existing valve replacement.

[0025] Such as figure 1 As shown, the method for preparing a drug-loaded aortic valve based on 3D printing proposed by this application includes the following steps:

[0026] Step S11: Obtain medical image data of the aortic valve.

[0027] A large amount of imaging data of aortic valve in normal volunteers was collected, and a statistical model of normal human aortic valve was constructed.

[0028] Step S12: Building a three-dimensional model of the aortic valve based on the acquired medical image data of the aortic valve.

[0029] Through the image proc...

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Abstract

The invention discloses a method for preparing a drug-loading aortic valve based on 3D printing and the drug-loading aortic valve, aiming at solving the technical problems of an existing valve replacement technique which requires anticoagulant therapy for a long time and is poor in durability. The method comprises the following steps: acquiring medical image data of the aortic valve; on the basis of the acquired medical image data of the aortic valve, establishing an aortic valve three-dimensional model; on the basis of the aortic valve three-dimensional model, forming a drug-loading aortic valve real body through 3D printing, wherein the drug-loading aortic valve real body comprises a valve ring real body and valve leaflet real bodies; forming drug-loading layers having drug-loading porous structures on the valve leaflet real bodies of the drug-loading aortic valve real body through 3D printing; and by virtue of a micro-droplet jetting technique, jetting anticoagulant drugs into the drug-loading porous structures of the drug-loading layers and jetting growth factors into the regions, except for the drug-loading porous structures, of the drug-loading layers, so as to form the drug-loading aortic valve. The printed aortic valve has a drug sustained-release function, the aortic valve is highly bionic and is capable of improving biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of human implanted medical devices, and in particular relates to a method for preparing a drug-loaded aortic valve based on 3D printing and a drug-loaded aortic valve. Background technique [0002] The heart valve is a key biological valve to ensure the directional flow of blood circulation. It has a fine structure and an important physiological function of regulating the direction of blood ejection. It also has the characteristics of elastic movement and high hydraulic pressure. [0003] Once the heart valve is damaged, it will change the blood flow of the human body, and it can be life-threatening in severe cases. Heart valve disease is one of the three most common heart diseases at present, and aortic valve disease is a kind of heart valve disease, which can cause symptoms such as palpitations and angina pectoris. [0004] At present, aortic valve disease is mainly treated by valve replacement. The cons...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/24B33Y30/00B33Y10/00B33Y50/00B33Y70/00
CPCA61F2/24B33Y10/00B33Y30/00B33Y50/00B33Y70/00
Inventor 王红胡登脉张楠
Owner 广州尤尼智康生物科技有限公司
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