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Sarafloxacin hydrochloride solid dispersion preparation and preparation method thereof

A technology of sarafloxacin hydrochloride and solid dispersion preparation, which is applied in the field of sarafloxacin hydrochloride solid dispersion preparation and its preparation, can solve the problems of limited application, poor water solubility of sarafloxacin hydrochloride, etc., and achieve promotion, low cost and simple prescription Effect

Active Publication Date: 2019-06-21
CHINANIMAL NANJING VETERINARY DRUGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sarafloxacin hydrochloride has poor water solubility, which greatly limits its application. In clinical application, it is necessary to find a preparation that is easy to dissolve at a high concentration to greatly improve the clinical use of this product.

Method used

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  • Sarafloxacin hydrochloride solid dispersion preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The sarafloxacin hydrochloride solid dispersion preparation of the present embodiment, its prescription composition and preparation technology are as follows:

[0021] Sarafloxacin hydrochloride 0.5g, povidone (PVPK15) 2g

[0022] First add povidone into ethanol, stir to dissolve povidone completely, the weight volume ratio of povidone to ethanol is 1g:20ml; then add sarafloxacin hydrochloride to it, continue stirring for at least 1.5 hours to make sarafloxacin hydrochloride Dissolve completely; evaporate the ethanol in a water bath at 80°C, dry the resulting solid under vacuum at 60°C, crush and sieve to obtain the finished product.

Embodiment 2

[0024] The sarafloxacin hydrochloride solid dispersion preparation of the present embodiment, its prescription composition and preparation technology are as follows:

[0025] Sarafloxacin hydrochloride 2g, povidone (PVPK15) 20g

[0026] First add povidone into ethanol, stir to dissolve povidone completely, the weight volume ratio of povidone to ethanol is 20g:100ml; then add sarafloxacin hydrochloride to it, continue stirring for at least 1.5 hours to make sarafloxacin hydrochloride Dissolve completely; evaporate the ethanol in a water bath at 80°C, dry the resulting solid under vacuum at 60°C, crush and sieve to obtain the finished product.

Embodiment 3

[0028] The sarafloxacin hydrochloride solid dispersion preparation of the present embodiment, its prescription composition and preparation technology are as follows:

[0029] Sarafloxacin hydrochloride 2g, povidone (PVPK15) 8g

[0030] First add povidone into ethanol, stir to dissolve povidone completely, the weight volume ratio of povidone to ethanol is 8g:50ml; then add sarafloxacin hydrochloride to it, continue stirring for at least 1.5 hours to make sarafloxacin hydrochloride Dissolve completely; evaporate the ethanol in a water bath at 80°C, dry the resulting solid under vacuum at 60°C, crush and sieve to obtain the finished product.

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Abstract

The invention discloses a sarafloxacin hydrochloride solid dispersion preparation and a preparation method thereof. A specific technical scheme is that the preparation method comprises the following steps: firstly, adding polyvidone into ethanol, stirring to completely dissolve the polyvidone; secondly, adding sarafloxacin hydrochloride into a mixture, continuously stirring to completely dissolve the sarafloxacin hydrochloride; after the ethanol is completely volatized in a water bath, performing vacuum drying, crushing and sieving on an obtained solid, thus obtaining a finished product. A prescription of the sarafloxacin hydrochloride solid dispersion preparation, disclosed by the invention, is extremely simple; by means of the preparation method which is specially designed and is simple in step, the sarafloxacin hydrochloride solid dispersion preparation of which the solubility in water can reach 1g / L can be obtained, is low in cost and facilitates popularization.

Description

technical field [0001] The invention relates to a solid dispersion preparation of sarafloxacin hydrochloride and a preparation method thereof, which are suitable for the field of veterinary medicine. Background technique [0002] As far as the inventor knows, Sarafloxacin (Sarafloxacin) is the first third-generation quinolones approved by the U.S. for food animals. Another FDA-approved veterinary-specific quinolone. It was first successfully developed by Abbott of the United States, and it is commonly seen as hydrochloride in clinical practice, that is, Sarafloxacin Hydrochloride. [0003] Sarafloxacin hydrochloride has a wide antibacterial spectrum and strong antibacterial activity. It has a good killing effect on Gram-positive bacteria, negative bacteria, anaerobic bacteria, mycoplasma, and chlamydia. It can be used to prevent and treat various bacterial diseases, such as swine , Escherichia coli disease, salmonellosis, mycoplasma disease and staphylococcal infection of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/496A61K47/32A61P31/04
CPCA61K9/146A61K31/496A61K47/32
Inventor 马小平徐瑞华符素萍戴银娣
Owner CHINANIMAL NANJING VETERINARY DRUGS