Application of lupenyl acetate

A technology of acetyl lupeyl ester and upper respiratory tract, which is applied in the field of medicine, can solve the problems of drugs for upper respiratory tract infection without acetyllupeyl ester, and achieve the effect of small side effects

Inactive Publication Date: 2017-01-04
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report on the application of acetyl lupeyl ester in the preparation of medicines for preventing and / or treating upper respiratory tract infection

Method used

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  • Application of lupenyl acetate
  • Application of lupenyl acetate
  • Application of lupenyl acetate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Experimental Research on Antiviral Effect of Acetyl Lupeyl Ester in Vitro

[0027] 1. Experimental materials

[0028] 1.1 Drugs

[0029] Ribavirin: Shandong Sunlu Pharmaceutical Co., Ltd.

[0030] 1.2 Materials

[0031] Virus species: Influenza virus FM1 strain was provided by the Institute of Medical Biotechnology, Chinese Academy of Medical Sciences, passaged in MDCK dog kidney cells, and its titer was determined by lesions and chicken red blood cell hemagglutination; rhinovirus R14 was provided by the Virus Institute, Chinese Academy of Medical Sciences , passaged in KMB17 diploid cells, and measured; respiratory syncytial virus was purchased from the Institute of Virology, Chinese Academy of Preventive Medicine, and was RSV-N3 strain, amplified on Hep-2 cells, and measured; adenovirus type 3 virus The species was provided by the Institute of Virology, Chinese Academy of Medical Sciences, passaged on Hela cells, and assayed; adenovirus type 7 was introd...

Embodiment 2

[0048] Embodiment 2: Experimental research on the antibacterial effect of acetyl lupeyl ester in vitro

[0049] 1. Experimental materials

[0050] 1.1 Drugs

[0051] Ciprofloxacin hydrochloride, Jiangjing New Pharmaceutical Co., Ltd.

[0052] 1.2 Materials

[0053] Standard strains: Staphylococcus aureus, Escherichia coli, Shigella, and Streptococcus beta were identified and provided by the Microbiological Reagent Factory of the Jiangsu Provincial Center for Disease Control and Prevention. Clinical isolates: Staphylococcus aureus, Escherichia coli, Acinetobacter, Klebsiella pneumoniae, Staphylococcus epidermidis, and Staphylococcus hominis were provided by the isolation and identification of the Microbiology Department of Jiangsu Provincial People's Hospital.

[0054] Nutrient broth, Shanghai Zhongke Insect Biotechnology Development Co., Ltd.

[0055] AL104 electronic balance, Mettler-Toledo Instrument Co., Ltd.

[0056] 1.3 Method

[0057] Adopt test tube method, get th...

Embodiment 3

[0064] Example 3: Experimental Research of Acetyl Lupeyl Ester on a Mouse Model of Upper Respiratory Tract Infection Caused by Influenza A Virus

[0065] 1. Experimental materials

[0066] 1.1 Drugs

[0067] Ribavirin: Shandong Sunlu Pharmaceutical Co., Ltd.

[0068] 1.2 Materials

[0069] AL104 electronic balance, Mettler-Toledo Instrument Co., Ltd.;

[0070] Centrifuge, Eppendorf 5424;

[0071] Microplate reader, molecular devices spectrumMax M2e;

[0072] Chicken embryo (9 days old), Nanjing Zhongmu Pharmaceutical Equipment Factory;

[0073] Mouse TNF-α test kit, Shanghai Yuanye Biotechnology Co., Ltd.;

[0074] Influenza A virus A / PR8 / 34 (H1N1), provided by the Institute of Virology, Chinese Academy of Preventive Medicine.

[0075] Animals: 90 ICR mice, weighing 13-16g, male, purchased from Beijing Weitong Lihua Experimental Animal Center;

[0076] Feed: Basic nutritional feed was provided by Qinglongshan Animal Breeding Farm in Jiangning.

[0077] 1.3 Method

[...

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Abstract

The invention relates to the technical field of medicine, and particularly discloses application of lupenyl acetate to preparation of medicine for treating and / or preventing upper respiratory infection, or preparation of virus and / or bacterium inhibiting agents. The lupenyl acetate is from natural traditional Chinese medicine plants, has small side effects, has a certain inhibition effect on rhinoviruses, influenza viruses, respiratory syncytial viruses, adenoviruses, coronaviruses, parainfluenza viruses, staphylococcus aureus, colon bacillus, dysentery bacillus, klebsiella pneumonia, staphylococcus epidermidis and staphylococcus hominis, and has a better effect on the upper respiratory infection caused by the viruses and bacteria; the novel path for treating the upper respiratory infection by using traditional Chinese medicine ingredients is provided.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of acetyl lupeyl ester. Background technique [0002] Upper respiratory tract infection, referred to as upper respiratory tract infection, is a general term for inflammation of the nasal cavity, pharynx, and larynx respiratory mucosa. Including the common cold, acute sinusitis, acute otitis media, etc. Clinical manifestations include fever, headache, nasal congestion, sore throat, and cough. It is one of the most common infectious diseases in humans. It is prone to complications and involves adjacent organs, such as the trachea, bronchi, ears, eyes, and neck lymph nodes. If it is not treated in time, it will develop into lower respiratory tract inflammation and is the cause of death for children under 5 years old. the first reason. [0003] This disease is mainly caused by viral infection, such as rhinovirus, influenza virus, coronavirus, etc.,...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K31/568A61P31/12A61P31/04A61P31/16A61P11/00
CPCA61K31/568Y02A50/30
Inventor萧伟曹泽彧丁玥孙兰曹亮王振中丁岗胡晗绯
OwnerJIANGSU KANION PHARMA CO LTD