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A high-persistence multi-effect self-crosslinking fluid gel and its preparation method and application

A self-crosslinking and gel technology, applied in the field of natural biomedical materials, can solve the problems of poor biocompatibility, high toxicity of crosslinking agent, residual crosslinking agent, etc., to reduce injection thrust and inhibit catabolism. , the effect of good enzyme resistance

Active Publication Date: 2019-07-19
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, cross-linking agents such as DVS, BDDE, and epichlorohydrin are highly toxic and have poor biocompatibility, and there is a risk of cross-linking agent residues in the product
When EDC or amino acids are used as cross-linking agents, although the biocompatibility is better, the cost is higher

Method used

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  • A high-persistence multi-effect self-crosslinking fluid gel and its preparation method and application
  • A high-persistence multi-effect self-crosslinking fluid gel and its preparation method and application
  • A high-persistence multi-effect self-crosslinking fluid gel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, the preparation of fluid gel

[0047] 1) Place carboxymethyl chitosan in purified water at 30°C and stir to fully dissolve it, then filter and collect the filtrate with a G3 sand core funnel. The molecular weight, carboxylation degree and concentration of carboxymethyl chitosan are 100,000, 82% and 10mg / ml; 2) Place the carboxymethyl chitosan aqueous solution in step 1) in a refrigerator at -20°C for 24h, then thaw at 10°C for 4h, and repeat the freeze-thaw twice to obtain high-persistence self-crosslinking Fluid gel; 3) chondroitin sulfate and polysulfated xylan are dissolved in pH buffer solution, the concentration and molecular weight of chondroitin sulfate are 20 mg / ml and 4000 Daltons respectively, and the concentration and molecular weight of polysulfated xylan are respectively 30mg / ml and 6000 Daltons, NaH 2 PO 4 6.28mg / ml, Na 2 HPO 4 11.6mg / ml, NaCl9.4mg / ml; 4) the gel of step 2) is mixed with the solution of step 3) in an equal volume ratio ...

Embodiment 2

[0048] Embodiment 2, the preparation of fluid gel

[0049] 1) Put hydroxypropyl chitosan in purified water at 50°C and stir to fully dissolve it, then use a G3 sand core funnel to filter and collect the filtrate. The molecular weight, degree of substitution, and concentration of hydroxypropyl chitosan are 200,000, 0.6, and 25 mg / ml; 2) Put the aqueous solution of hydroxypropyl chitosan in step 1) into a refrigerator at -30°C for 36 hours, then thaw it at 25°C for 3 hours, repeat the freezing and thawing process for 6 times, and obtain a high-persistence self-crosslinking fluid gel. Glue; 3) chondroitin sulfate and polysulfated xylan are dissolved in pH buffer solution, chondroitin sulfate concentration and molecular weight are respectively 50mg / ml and 5000 Daltons, polysulfated xylan concentration and molecular weight are respectively 60mg / ml ml and 7000 Daltons, NaH 2 PO 4 6.28mg / ml, Na 2 HPO 4 11.6mg / ml, NaCl 9.4mg / ml; 4) Mix the gel in step 2) and the solution in ste...

Embodiment 3

[0050] Embodiment 3, the preparation of fluid gel

[0051] 1) Place carboxymethyl chitosan in purified water at 65°C and stir to fully dissolve it, then filter and collect the filtrate with a G3 sand core funnel. The molecular weight, carboxylation degree and concentration of carboxymethyl chitosan are respectively 300,000, 90% and 40mg / ml; 2) Place the carboxymethyl chitosan aqueous solution in step 1) in a -40°C refrigerator for 48h, then thaw at 20°C for 3h, and repeat the freeze-thaw 8 times to obtain high-persistence self-crosslinking Fluid gel; 3) chondroitin sulfate and xylan polysulfate are dissolved in pH buffer solution, chondroitin sulfate concentration and molecular weight are 80mg / ml and 6000 Daltons respectively, xylan polysulfate concentration and molecular weight are respectively 60mg / ml and 8000 Daltons, NaH 2 PO 4 6.28mg / ml, Na 2 HPO 4 11.6mg / ml, NaCl 9.4mg / ml; 4) Mix the gel in step 2) and the solution in step 3) at an equal volume ratio of 1:1 and hom...

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Abstract

The invention provides high-durability multi-effect self-crosslinking fluid gel as well as a preparation method and an application thereof. The preparation method of the fluid gel comprises steps as follows: 1) water-soluble chitosan is placed in purified water and dissolved, and a water-soluble chitosan water solution is obtained; filtration is performed, and filtrate is collected; 2) all filtrate is repeatedly frozen and thawed, and high-durability self-crosslinking fluid gel is obtained; 3) the high-durability self-crosslinking fluid gel and a function modifier are mixed, and the fluid gel is obtained. The fluid gel has the characteristics of homogeneous phase, high durability and multiple effects; a preparation method is simple, and a physical self-crosslinking reaction is adopted; the application has biological safety.

Description

technical field [0001] The invention relates to a high-durability multi-effect self-crosslinking fluid gel and a preparation method and application thereof, belonging to the field of natural biomedical materials. Background technique [0002] Due to aging, injury and trauma, overweight, overuse of one side, lack of physical exercise in joints or related structures such as bones, ligaments and cartilage, a series of degenerative diseases of bones and joints may be caused, which brings a lot of inconvenience to daily life. The most common of these is osteoarthritis (OA). OA is currently the leading cause of disability in the United States, and the associated treatment costs for American patients are approximately $5,700 per year. Currently, OA has caused 43 million people with moderate to severe disabilities worldwide. The prevalence rate of knee arthritis in my country is about 9.56%. There is currently no cure for OA, and injectable viscoelastic supplements are an importa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/50A61L27/52A61L27/54A61L27/58
CPCA61L27/20A61L27/50A61L27/52A61L27/54A61L27/58A61L2300/232A61L2300/236A61L2300/412A61L2400/06A61L2430/06C08L5/08
Inventor 周颖郭刚孙先昌
Owner YANTAI ZHENGHAI BIO TECH
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