Novel indolopyrrole compound, preparation method and use thereof
An indolopyrrole and compound technology, which is applied in the field of antibacterial drug preparation, can solve the problems of high synthesis difficulty, poor compound stereoconfiguration selectivity, and lack of visibility, and achieves the effects of simplified synthesis difficulty, good bacteriostatic activity and antibacterial spectrum.
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[0034] In order to illustrate the present invention more clearly, the present invention will be further described below in conjunction with preferred embodiments and accompanying drawings. Similar parts in the figures are denoted by the same reference numerals. Those skilled in the art should understand that the content specifically described below is illustrative rather than restrictive, and should not limit the protection scope of the present invention.
[0035] 1. Synthesis of indolopyrrole compounds
[0036] The synthetic route of the indolopyrrole compound of the present embodiment is shown in formula 1 below:
[0037] (1)Oxindole-3-acetonitrile IAN 1 Synthesis:
[0038]
[0039] Weigh 3.12g (20mmol) of indole-3-acetonitrile and place it in a dry 100mL round-bottomed flask, then add 30mL of DMSO, stir at room temperature for 15min to dissolve completely, place the reaction solution in an ice bath at 0°C, and then Slowly drip 150mL concentrated hydrochloric acid the...
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