A centella asiatica extract with anti-inflammatory and soothing effects and its application

Abstract

The invention belongs to the technical field of extraction of Chinese herbal medicine, and particularly relates to a herba centellae extract with anti-inflammation and anti-sensitivity effects. The herba centellae extract is prepared by adopting the following preparation method: S1. adding ethanol into herba centellae powder for extraction, carrying out ultrasonic assisted extraction, then centrifuging or filtering, and collecting a filtrate; S2. adding activated carbon to the filtrate obtained in step 1 for decoloring, centrifuging, and collecting a decolored filtrate; S3. concentrating the decolored filtrated obtained in step 2, adding a chitosan liquid for decontamination, filtering, and collecting a decontaminated filtrate; S4. adding macroporous adsorption resin to the decontaminated filtrate for purification, and eluting with ethanol to obtain an eluent; S5. concentrating, desalting and drying the eluent obtained in step 4 to obtain the herba centellae extract, wherein in S1, the concentration of ethanol is 60-90%, the ultrasonic power is 228W-380W, and the material-to-liquid ratio is 1:20-80. The herba centellae extract provided by the invention has remarkable anti-inflammation and anti-sensitivity effects, is prominent in oxidation resistant and free radical removal effects, and can be widely applied to skin care products with anti-inflammation and anti-sensitivity effects.

Description

technical field [0001] The invention belongs to the technical field of extracting Chinese herbal medicines, and more specifically relates to a centella asiatica extract with anti-inflammatory and soothing effects and its application. Background technique [0002] Centella asiatica, also known as Lianmo grass, Calla hoofensis, Bengdawan, etc., is the dry or rooted whole plant of the Umbelliferae plant Centella asiatica. Centella asiatica is widely distributed in China, mainly in South China, East China, Central South and Southwest China. [0003] Centella asiatica has a long history of being used as medicine in my country. People have accumulated rich experience in the field of traditional Chinese medicine for a long time. Centella asiatica was first recorded in "Shen Nong's Materia Medica". It is cold in nature, non-toxic, and belongs to the liver, spleen, and kidney meridians. It has the functions of promoting blood circulation, reducing swelling and relieving pain, and has...

AI Technical Summary

Problems solved by technology

[0006] The Chinese patent with the publication number CN 101455693 discloses a method for extracting the total glucosides of Centella Asiatica from Centella asiatica by percolation technology. The extraction method does not further purify the crude extract, and the content of functional components is low; the publication number is The Chinese patent of CN101456894 discloses a method for preparing the total aglycone of Centella asiatica by hydrolyzing the total glycosides of Centella asiatica. The method needs a large amount of acid and alkali and the raw material for the preparation is asiaticoside; the Chinese publication number CN 103079573 The patent discloses a method for preparing a high-purity asiaticoside composition by using Centella asiatica. The method adopts fixed-bed countercurrent extraction technology to repeatedly extract asiaticoside, and obtains relatively high-purity asiaticoside through purification with reagents such as methanol and methyl isobutyl ketone. For high-purity asiaticoside, the extraction equipment is complex and the extraction steps are cumbersome

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