Phenylethanol glycosides extracted from thistle and its preparation method and use

A technology of phenylethanol glycosides and compounds, which is applied in the field of natural medicinal chemistry, can solve the problem of insufficient penetration of thistle, and achieve the effects of remarkable curative effect, convenient operation and novel structure

Inactive Publication Date: 2017-12-15
NANYANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, people's research on the chemical components of thistle is not deep enough, and it is necessary to further explore its active components, clarify the relationship between its pharmacological activity and active components, and lay a theoretical foundation for humans to discover new drugs from natural plants

Method used

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  • Phenylethanol glycosides extracted from thistle and its preparation method and use
  • Phenylethanol glycosides extracted from thistle and its preparation method and use
  • Phenylethanol glycosides extracted from thistle and its preparation method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Such as figure 1 As shown, take 8kg of dry whole plant of thistle as raw material, extract twice with 70% ethanol (18L×2), each time for 1.5 hours, filter the extract, combine the filtrates, concentrate under reduced pressure at 40°C until alcohol-free Taste obtains total thick cream 0.9kg. Suspend the obtained total thick paste and water in an appropriate amount of water according to the volume ratio of 1:1, and sequentially extract 3 times with petroleum ether, ethyl acetate and n-butanol to obtain 83.5 g of petroleum ether partial extracts, and ethyl acetate partial extractions. Product 185.7g, n-butanol partial extract 238.1g. According to the pharmacological screening results of the previous extracts, the extract from the n-butanol fraction was determined to be the active fraction. Put 238.1g of n-butanol extract on a macroporous adsorption resin column (Diaion-101), and sequentially use 10%, 25%, 45%, 95% ethanol for gradient elution to obtain A, B, C, D four ki...

Embodiment 2

[0026] Take 12 kg of dry whole plant of thistle as raw material, extract 3 times with 85% ethanol (18L×3), 2 hours each time, filter the extract, combine the filtrates, concentrate under reduced pressure at 45°C until there is no alcohol smell to obtain the total Thick paste 1.3kg. Suspend the obtained total thick paste and water in an appropriate amount of water according to the volume ratio of 1:1, and sequentially extract 4 times with petroleum ether, ethyl acetate and n-butanol to obtain 110.2 g of petroleum ether partial extracts, and 110.2 g of partial extractions with ethyl acetate. Product 202.5g, n-butanol partial extract 280.4g. According to the pharmacological screening results of the previous extracts, it was determined that the n-butanol part of the extract was the active site. Put 280.4g of n-butanol extract on a macroporous adsorption resin column (Diaion-101), and sequentially use 15%, 30%, 60%, 95% ethanol for gradient elution to obtain A, B, C, D four kinds ...

Embodiment 3

[0028] Take 15kg dried whole plant of thistle as raw material, extract 4 times with 95% ethanol (20L×4), 3 hours each time, filter the extract, combine the filtrates, concentrate under reduced pressure at 48°C until no alcohol smell is obtained The total thick cream is 1.6kg. The obtained total thick paste and water were suspended in an appropriate amount of water according to the volume ratio of 1:1, and were extracted 4 times with petroleum ether, ethyl acetate and n-butanol successively to obtain 156.4 g of petroleum ether partial extracts, and 156.4 g of ethyl acetate partial extractions. Product 254.2g, n-butanol partial extract 304.7g. According to the pharmacological screening results of the previous crude extract, it was determined that the extract from the n-butanol fraction was the active fraction. Put 304.7g of n-butanol partial extract on macroporous adsorption resin column (Diaion-101), and carry out gradient elution with 20%, 40%, 70%, 95% ethanol in sequence to...

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Abstract

The invention discloses a phenethyl alcohol glycoside compound extracted from a common cephalanoplos herb and application. The phenethyl alcohol glycoside compound is shown as a formula (I). According to the principle of 'homology of medicine and food', the common cephalanoplos herb is selected as a research object, and a modern extracting and separating technology is adopted to simply, conveniently and effectively separate and purify the common cephalanoplos herb so as to obtain the new phenethyl alcohol glycoside compound. The compound is novel in structure, has very good lipid-lowering activity and an anti-oxidation effect, can be applied to preparation of lipid-lowering medicines, especially to preparation of weight-reducing medicines, and can be also applied to preparation of anti-oxidation medicines, especially to preparation of free-radical scavenger medicines. An important theoretical basis is laid for further development of novel weight-reducing medicines remarkable in treating effect and small in toxic and side effect and medicines having the anti-oxidation effect.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and relates to phenylethanol glycosides extracted from thistle, a preparation method and application thereof. Background technique [0002] Thistle (Cirsium setosum) is a plant of the genus Thistle in the family Asteraceae. It is commonly known as thorn horn bud in the folk, also known as thorn vegetable, which is rich in various nutrients. For a long time, it has been loved by people as a kind of wild vegetable. As a wild plant for both medicine and food, thistle is widely distributed in most parts of China, and also in Central Europe, Eastern Europe, Eastern Russia, Japan, North Korea and other regions. Thistle is cool in nature, sweet in the mouth, bitter in the mouth, returns to heart, Liver meridian, has the effect of cooling blood to stop bleeding, dispelling blood stasis, detoxifying and eliminating carbuncle. Studies have found that thistle contains chemical components such as...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/18C07H1/08A61K31/7028A61P3/04A61P39/06
CPCC07H1/08C07H15/18
Inventor 马勤阁魏荣锐李亭徐坤桑志培郭锦辉孙潇潇
Owner NANYANG NORMAL UNIV
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