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Application of phillygenin in preparing medicine for treating autoimmune hepatitis

An autoimmune, forsythia aglycone technology, applied in the field of medicine, achieves the effect of exact curative effect, significant treatment and prevention effect, and low cost

Active Publication Date: 2017-01-11
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, immunosuppressants have many side effects, especially in long-term application. Therefore, regular review should be paid attention to in the course of treatment to prevent complications, so as to ensure the smooth progress of treatment.

Method used

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  • Application of phillygenin in preparing medicine for treating autoimmune hepatitis
  • Application of phillygenin in preparing medicine for treating autoimmune hepatitis
  • Application of phillygenin in preparing medicine for treating autoimmune hepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Forsythiagenin Injection

[0020]

[0021] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add forsythiagenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% needle, stir with activated carbon, decarbonize, and then pack it. .

Embodiment 2

[0022] Example 2 Forsythiagenin Injection

[0023]

[0024] Preparation process: mix the prescribed amount of PEG-400 with ethanol, add forsythiaside, stir to dissolve, add 0.9% sodium chloride solution to 10000ml, stir evenly, add 0.5% needle, stir with activated carbon, decarbonize, and then pack it. .

Embodiment 3

[0025] Example 3 Forsythiagenin Injection

[0026]

[0027] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add forsythiagenin, stir to dissolve, add water for injection to 10000ml, stir evenly, add 0.5% activated carbon for needles, stir for decarbonization, and then divide and pack.

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PUM

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Abstract

The invention relates to medical application of phillygenin and particularly relates to application of phillygenin in preparing a medicine for treating autoimmune hepatitis, belonging to the field of medicine. The treatment effect of existing immunosuppressant on autoimmune hepatitis is not good enough, and multiple side effects are caused; on the basis, the invention provides a medicine for treating autoimmune hepatitis, wherein phillygenin is used as a main active ingredient; animal experiments indicate that the phillygenin can remarkably improve the level of interleukin 2 and gamma-interferon while noticeably reducing the level of interleukin 4 and interleukin 6; when used for treating autoimmune hepatitis, the phillygenin has the characteristics of exact curative effect and low adverse reaction and is suitable for being prepared into a clinical medicine for treating autoimmune hepatitis.

Description

technical field [0001] The invention relates to a medical application of forsythiagenin, in particular to the application of forsythinin in the preparation of medicines for treating autoimmune hepatitis, and belongs to the field of medicine. Background technique [0002] Autoimmune hepatitis is a liver tissue injury caused by the expression of specific or non-specific autoantigens, and is a chronic inflammatory disease of the liver with unknown etiology. The clinical features of this disease are liver function damage, increased plasma immunoglobulin, and the presence of various autoantibodies in the blood circulation. Autoimmune liver diseases such as chronic cholangitis (PSC) often overlap in clinical manifestations, biochemical, immune and histological changes, making the clinical diagnosis and treatment of autoimmune hepatitis quite difficult. The International Autoimmune Hepatitis Conference held in 1992 formulated the diagnostic criteria for AIH: ① hypergammaglobulinem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61P1/16A61P37/02
Inventor 张贵民姚景春冯芹吴园芳王恩力
Owner LUNAN PHARMA GROUP CORPORATION
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