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Sandalwood oil extract and application thereof

A technology of sandalwood oil and extract, which is applied in the field of sandalwood oil extract, can solve the problems of mixed sources, different medicinal effects, and different active ingredients, and achieve the effect of high resolution and easy identification

Inactive Publication Date: 2017-02-01
浙江苏可安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the sources of sandalwood medicinal materials are mixed, which leads to many differences in the active ingredients of sandalwood oil extracts, resulting in significantly different medicinal effects.

Method used

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  • Sandalwood oil extract and application thereof
  • Sandalwood oil extract and application thereof
  • Sandalwood oil extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0080] Weigh 100.0g sandalwood medicinal material, shavings, soak for 12h, extract by steam distillation for 5h, take the upper layer of volatile oil and dehydrate it with anhydrous sodium sulfate, filter to obtain the sandalwood oil extract, keep away from light, seal and store for later use.

[0081] The above-mentioned volatile oil components were detected by gas chromatography, and the retention times of 19.434, 19.655, 24.179, 24.710, 25.197, 27.298, 27.762, 29.531 and 29.902 were respectively selected as peaks 1-9. For the gas chromatogram of sandalwood oil C see figure 1 . According to the gas chromatograms of sandalwood oils A~E, the parameters of their respective characteristic peaks are obtained, which are listed in Table 1.

[0082] Table 1 The gas chromatographic characteristic peak areas of sandalwood oil extracts from different sources

[0083] Types of Sandalwood Oil Extract Sandalwood Oil A Sandalwood oil B Sandalwood Oil C Sandalwood oil D...

experiment example

[0086] 1. Experimental animals and reagents

[0087] 1.1 Animal grouping

[0088] Select 50 healthy New Zealand rabbits, half male and half male (purchased and raised by the Animal Experiment Center of Zhejiang Academy of Traditional Chinese Medicine), grouped as follows: model group, positive group, negative group, sandalwood oil A group, sandalwood oil B group, sandalwood oil Group C, sandalwood oil group D, sandalwood oil group E, and nitroglycerin aerosol group were divided into 10 groups on average according to the weight difference of each animal, with 5 animals in each group. The administration method of each group is as follows:

[0089] (1) Model group: Distilled water was instilled under the tongue.

[0090] (2) Positive group: nitroglycerin liquid was instilled under the tongue.

[0091] (3) Negative group: Sublingual instillation of medicinal liquid lacking sandalwood oil.

[0092] (4) Sandalwood oil A group: the liquid medicine containing sandalwood oil A was ...

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Abstract

The invention discloses a sandalwood oil extract and application thereof. According to gas chromatography of the sandalwood oil extract, characteristic peaks exist at the positions where the retention times are 19.434, 24.179, 25.197, 27.762, 29.531 and 29.902, wherein the unit of the retention times is minute, and the difference of the retention times is + / -5%. The sandalwood oil extract has the advantage that the effects can be quickly achieved when the sandalwood oil extract is used for treating or relieving diseases such as angina pectoris.

Description

technical field [0001] The invention relates to a sandalwood oil extract and its application. Background technique [0002] Wide chest aerosol is an important drug for relieving angina pectoris. Its main ingredients are asarum oil, sandalwood oil, galangal oil, longong oil and borneol. The main component of Wide Chest Aerosol is volatile oil, which can be quickly absorbed into the blood by the human body, expand coronary vessels, significantly improve myocardial ischemia, and quickly relieve symptoms of angina such as chest tightness, chest pain, palpitations, shortness of breath, and fatigue. Among them, sandalwood oil is a very important ingredient. [0003] With regard to sandalwood oil, current research is mainly focused on improving the application of sandalwood oil. For example, CN1732908 A discloses a spray containing borneol, which contains 0.01-20% borneol, 5-40% ethanol and neutral fatty oil in its liquid medicine, and can also contain asarum oil, sandalwood oil,...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K36/9062A61P9/10G01N30/02G01N30/06A61K31/045
CPCA61K36/185A61K31/045A61K36/268A61K36/67A61K36/9062G01N30/02G01N30/06A61K2300/00
Inventor 苏艳傅崇林陈乃智鲁潇
Owner 浙江苏可安药业有限公司
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