Chitin/carbon nanotube composite adsorbent for blood perfusion and preparation method thereof

A carbon nanotube composite and carbon nanotube technology is applied in the field of natural polymer biomedical materials to achieve the effects of easy popularization and application, good compatibility and high adsorption efficiency

Active Publication Date: 2017-02-08
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no adsorbent material with excellent adsorption effect, strong ability to selectively remove bilirubin, good biocompatibility and hemocompatibility, which can be used for whole blood perfusion, and reasonable price

Method used

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  • Chitin/carbon nanotube composite adsorbent for blood perfusion and preparation method thereof
  • Chitin/carbon nanotube composite adsorbent for blood perfusion and preparation method thereof
  • Chitin/carbon nanotube composite adsorbent for blood perfusion and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Embodiment 1 Preparation of chitin / carbon nanotube composite nanofiber microspheres

[0045] The preparation method of chitin / NaOH / urea aqueous solution is the prior art, and it is used according to the method disclosed in ZL200310111566.3. Disperse 4 g of chitin powder in 96 g of NaOH / urea aqueous solution and stir for 10 min (NaOH: urea = 11:4), freeze at -35°C for 4 hours, and then stir and thaw at room temperature. After 3 cycles of freezing / thawing, a clear and transparent chitin solution with a concentration of 4% by weight was obtained. The chitin solution was centrifuged at 4°C and 7000 rad / min for 10 minutes, degassed and removed undissolved impurities to obtain The chitin solution is ready for use.

[0046] Add 1g of purchased carbon nanotubes to 150mL concentrated sulfuric acid, stir magnetically for 30min, add 50mL concentrated nitric acid, stir magnetically for 2h under reflux at 60°C, pour it into a large amount of deionized water to dilute after cooling,...

Embodiment 2

[0048] Preparation of Example 2 Chitin / Carbon Nanotube Composite Nanofiber Microspheres

[0049] Disperse 4g of chitin powder and 0.2g of acidified carbon nanotube powder in a mixture of 96g of 11wt% NaOH / 4wt% urea / 85wt% water, stir for 10min, place in a cold trap at -35°C for 4 hours, and then place at room temperature Stir to thaw. After 3 cycles of freezing / thawing to obtain a uniformly dissolved and dispersed chitin / carbon nanotube composite solution, add 2 mL of epichlorohydrin, stir at 0°C for 30 minutes, then centrifuge at 4°C, 7000 rad / min for 10 minutes, and remove Soak and remove undissolved impurities to obtain a chitin / carbon nanotube composite solution and place it in a refrigerator at 4°C for 2 hours for later use. Add 5 mL of Span 85 into 100 mL of isooctane, stir at 800 rad / min for 1 h at 0 ° C, then add 100 mL of epichlorohydrin-crosslinked chitin / carbon nanotube composite solution and continue stirring for 1 h, remove the ice bath, Raise the temperature of ...

Embodiment 3

[0050] Example 3 Preparation of Chitin / Carbon Nanotube Composite Nanofiber Microspheres

[0051] Add 50g of carbon nanotube dispersion to 100g of chitin solution, and stir in an ice bath at 1200rad / min for 1h, freeze the mixture at -35°C for 4 hours, then stir and thaw at room temperature, centrifuge at low temperature to defoam and The undissolved impurities are removed to obtain a chitin / carbon nanotube mixed solution in which the carbon nanotubes are uniformly dispersed. Add 10mL Span 85 into 100mL isooctane, stir at 800rad / min for 1h at 0°C, then add 150mL chitin / carbon nanotube composite solution and continue stirring for 1h, remove the ice bath, and raise the temperature of the water bath to 80° C., maintaining the stirring speed and the temperature of the hot water bath for 10 minutes, and then adding 10% dilute hydrochloric acid dropwise to adjust the pH value of the mixture to 7.0. Stand still until the mixture system is divided into two layers, pour off the upper la...

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Abstract

The invention discloses a chitin/carbon nanotube composite adsorbent for blood perfusion and a preparation method thereof. The preparation method comprises the following steps of: by taking a natural macromolecular material chitin as a carrier, under a low-temperature stirring condition, performing freezing-unfreezing circulation so as to combine the chitin dissolved in an alkali/urea water solvent system with carbon nanotubes and form a uniform chitin/carbon nanotube composite solution, performing emulsification and thermal induction self-assembling process, thereby forming chitin/carbon nanotube composite nano fiber microspheres. The prepared microspheres have through hole canals applicable to free diffusion of bilirubin, have a good adsorption effect on combined bilirubin, and moreover are excellent in biocompatibility and blood compatibility. The composite nano fiber microspheres can be also fixed with an effective amount of high-activity ligand through covalent bonds, and the cleaning property and biocompatibility of the bilirubin of the microspheres can be further improved.

Description

technical field [0001] The invention belongs to the field of natural macromolecule biomedical materials, and relates to a chitin / carbon nanotube composite adsorbent and a preparation method thereof, which are applied to hemoperfusion to remove toxins in blood and to treat various liver diseases. Background technique [0002] Liver cancer, severe hepatitis and liver failure are critical diseases that seriously threaten people's health. The disease has a high incidence rate and a dangerous condition. The traditional treatment has a high mortality rate and there is no good treatment strategy. It is a clinical problem that needs to be solved urgently. The disease is characterized by severe impairment of liver function, causing metabolic disorders in the body, making a large amount of toxins unable to be metabolized and accumulated in the body, causing toxicity to various organs and causing serious complications. Among them, bilirubin (Bilirubin BR) is the most important toxin su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/28B01J20/30
CPCB01J20/205B01J20/24B01J20/28016B01J20/28061B01J20/28083B01J20/28095
Inventor 张俐娜吴双泉段博叶啟发王彦峰
Owner WUHAN UNIV
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